Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(18), P. 10920 - 10989
Published: Sept. 15, 2023
Anticancer
nanomedicines
have
been
proven
effective
in
mitigating
the
side
effects
of
chemotherapeutic
drugs.
However,
challenges
remain
augmenting
their
therapeutic
efficacy.
Nanomedicines
responsive
to
pathological
abnormalities
tumor
microenvironment
(TME)
are
expected
overcome
biological
limitations
conventional
nanomedicines,
enhance
efficacies,
and
further
reduce
effects.
This
Review
aims
quantitate
various
TME,
which
may
serve
as
unique
endogenous
stimuli
for
design
stimuli-responsive
provide
a
broad
objective
perspective
on
current
understanding
cancer
treatment.
We
dissect
typical
transport
process
barriers
drug
delivery,
highlight
key
principles
designed
tackle
series
delivery
process,
discuss
"all-into-one"
"one-for-all"
strategies
integrating
needed
properties
nanomedicines.
Ultimately,
we
insight
into
future
perspectives
toward
clinical
translation
Journal of Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: Jan. 10, 2022
Abstract
Surface
charge
of
biological
and
medical
nanocarriers
has
been
demonstrated
to
play
an
important
role
in
cellular
uptake.
Owing
the
unique
physicochemical
properties,
charge-reversal
delivery
strategy
rapidly
developed
as
a
promising
approach
for
drug
application,
especially
cancer
treatment.
Charge-reversal
are
neutral/negatively
charged
at
physiological
conditions
while
could
be
triggered
positively
by
specific
stimuli
(i.e.,
pH,
redox,
ROS,
enzyme,
light
or
temperature)
achieve
prolonged
blood
circulation
enhanced
tumor
uptake,
thus
potentiate
antitumor
effects
delivered
therapeutic
agents.
In
this
review,
we
comprehensively
summarized
recent
advances
nanocarriers,
including:
(i)
effect
surface
on
uptake;
(ii)
charge-conversion
mechanisms
responding
several
stimuli;
(iii)
relation
between
chemical
structure
reversal
activity;
(iv)
polymeric
materials
that
commonly
applied
systems.
Graphical
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: July 16, 2022
Nanoparticle
elasticity
is
crucial
in
nanoparticles'
physiological
fate,
but
how
this
occurs
largely
unknown.
Using
core-shell
nanoparticles
with
a
same
PEGylated
lipid
bilayer
shell
yet
cores
differing
(45
kPa
-
760
MPa)
as
models,
we
isolate
the
effects
of
nanoparticle
from
those
other
physiochemical
parameters
and,
using
mouse
observe
non-monotonic
relationship
systemic
circulation
lifetime
versus
elasticity.
Incubating
our
plasma
provides
protein
coronas
varying
non-monotonically
composition
depending
on
Particularly,
apolipoprotein
A-I
(ApoA1)
only
whose
relative
abundance
corona
strongly
correlates
blood
clearance
lifetime.
Notably,
similar
results
are
observed
when
above
changed
to
be
non-PEGylated.
This
work
unveils
mechanisms
by
which
affects
fate
and
suggests
readily
tunable
parameter
future
rational
exploiting
corona.
Proceedings of the National Academy of Sciences,
Journal Year:
2022,
Volume and Issue:
119(23)
Published: June 2, 2022
Significance
This
study
analyzed
the
dynamic
protein
corona
on
surface
of
nanoparticles
as
they
traversed
from
blood
to
cell
lysosomes
and
escaped
cytoplasm
in
target
cells.
We
found
with
proteomic
analysis
an
abundance
chaperone
glycolysis
coronal
proteins
(i.e.,
heat
shock
cognate
70,
90,
pyruvate
kinase
M2
[PKM2])
after
escape
cytosol.
Alterations
(e.g.,
PKM2
binding)
induced
proteostasis
collapse,
which
subsequently
led
elevated
chaperone-mediated
autophagy
(CMA)
activity
As
is
a
key
molecule
metabolism,
we
also
revealed
that
depletion
was
causative
CMA-induced
metabolism
disruption
lipid
metabolism.
Acta Pharmaceutica Sinica B,
Journal Year:
2023,
Volume and Issue:
13(11), P. 4391 - 4416
Published: May 20, 2023
Owing
to
the
inherent
shortcomings
of
traditional
therapeutic
drugs
in
terms
inadequate
efficacy
and
toxicity
clinical
treatment,
nanomedicine
designs
have
received
widespread
attention
with
significantly
improved
reduced
non-target
side
effects.
Nanomedicines
hold
tremendous
theranostic
potential
for
treating,
monitoring,
diagnosing,
controlling
various
diseases
are
attracting
an
unfathomable
amount
input
research
resources.
Against
backdrop
exponentially
growing
number
publications,
it
is
imperative
help
audience
get
a
panorama
image
activities
field
nanomedicines.
Herein,
this
review
elaborates
on
development
trends
nanomedicines,
emerging
nanocarriers,
vivo
fate
safety
their
extensive
applications.
Moreover,
challenges
obstacles
hindering
translation
nanomedicines
also
discussed.
The
elaboration
aspects
may
enlighten
readers
set
route
future
endeavors.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(18), P. 10920 - 10989
Published: Sept. 15, 2023
Anticancer
nanomedicines
have
been
proven
effective
in
mitigating
the
side
effects
of
chemotherapeutic
drugs.
However,
challenges
remain
augmenting
their
therapeutic
efficacy.
Nanomedicines
responsive
to
pathological
abnormalities
tumor
microenvironment
(TME)
are
expected
overcome
biological
limitations
conventional
nanomedicines,
enhance
efficacies,
and
further
reduce
effects.
This
Review
aims
quantitate
various
TME,
which
may
serve
as
unique
endogenous
stimuli
for
design
stimuli-responsive
provide
a
broad
objective
perspective
on
current
understanding
cancer
treatment.
We
dissect
typical
transport
process
barriers
drug
delivery,
highlight
key
principles
designed
tackle
series
delivery
process,
discuss
"all-into-one"
"one-for-all"
strategies
integrating
needed
properties
nanomedicines.
Ultimately,
we
insight
into
future
perspectives
toward
clinical
translation
