A Review on MoS2 Properties, Synthesis, Sensing Applications and Challenges

Crystals, Journal Year: 2021, Volume and Issue: 11(4), P. 355 - 355

Published: March 29, 2021

Molybdenum disulfide (MoS2) is one of the compounds discussed nowadays due to its outstanding properties that allowed usage in different applications. Its band gap and distinctive structure make it a promising material substitute graphene other semiconductor devices. It has applications electronics especially sensors like optical sensors, biosensors, electrochemical biosensors play an important role detection various diseases’ cancer Alzheimer. wide range energy batteries, solar cells, microwave, Terahertz on nanoscale level, with favorable characteristics spintronics magnetoresistance. In this review, we will discuss MoS2 properties, synthesis techniques focus future challenges.

Language: Английский

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A Hollow Amorphous Bimetal Organic Framework for Synergistic Cuproptosis/Ferroptosis/Apoptosis Anticancer Therapy via Disrupting Intracellular Redox Homeostasis and Copper/Iron Metabolisms

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(40)

Published: July 30, 2022

Abstract Cuproptosis is a very newly recognized regulated cell death modality that distinct from known mechanisms and shows enormous prospect in cancer treatment. However, its efficacy copper‐dependent restricted by strictly copper metabolism. Herein, novel copper/iron hybrid hollow amorphous metal organic framework (HaMOF) developed as an oxidative stress amplifier metabolic disrupter for synergistic cuproptosis/ferroptosis/apoptosis anticancer therapy. The HaMOF fabricated Cu 2+ , 3,3′‐dithiobis(propionohydrazide) Fe 3+ via unsaturated coordination‐etching integration strategy, then doxorubicin loaded followed surface decoration with hyaluronan. obtained DOX@Fe/CuTH exhibits tumor microenvironment‐triggered catalytic therapeutic property, wherein it can amplify cellular simultaneously boosting H 2 O production depleting glutathione. Moreover, cause mitochondrial dysfunction downregulate the expressions of transporter ATP7A iron FPN 1, thereby leading to disorders high retentions cytoplasm •OH generation. overloaded lipoylated protein dihydrolipoamide S‐acetyltransferase aggregation lead cuproptosis. Collectively, both augmented induce potent ferroptosis, which synergizes cuproptosis DOX‐mediated apoptosis efficiently suppress growth. This bimetallic nanoplatform provides new paradigm boost cuproptosis‐related therapies.

Language: Английский

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Photocatalytic Antimicrobials: Principles, Design Strategies, and Applications

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(22), P. 12371 - 12430

Published: Aug. 24, 2023

Nowadays, the increasing emergence of antibiotic-resistant pathogenic microorganisms requires search for alternative methods that do not cause drug resistance. Phototherapy strategies (PTs) based on photoresponsive materials have become a new trend in inactivation due to their spatiotemporal controllability and negligible side effects. Among those phototherapy strategies, photocatalytic antimicrobial therapy (PCAT) has emerged as an effective promising strategy recent years. In process treatment, are excited by different wavelengths lights produce reactive oxygen species (ROS) or other toxic killing various microbes, such bacteria, viruses, fungi, parasites, algae. Therefore, this review timely summarizes latest progress PCAT field, with emphasis development antimicrobials (PCAMs), underlying mechanisms, design multiple practical applications local infections therapy, personal protective equipment, water purification, coatings, wound dressings, food safety, antibacterial textiles, air purification. Meanwhile, we also present challenges perspectives widespread implementation therapeutics. We hope result review, will flourish weapon against antibiotic

Language: Английский

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Self-Adaptive Single-Atom Catalyst Boosting Selective Ferroptosis in Tumor Cells

ACS Nano, Journal Year: 2022, Volume and Issue: 16(1), P. 855 - 868

Published: Jan. 13, 2022

Ferroptosis, resulting from the catastrophic accumulation of lipid reactive oxygen species (ROS) and inactivation glutathione (GSH)-dependent peroxidase 4 (GPX4), has emerged as a form regulated cell death for cancer therapy. Despite progress made with current ferroptosis inducers, efficient systems to trigger remain challenging, owing largely their low activity, uncontrollable behavior, even nonselective interactions. Here, we report self-adaptive platform by engineering DNA modulator onto surface single-atom nanozymes (SAzymes). The could not only specifically intensify ROS-generating activity but also endow SAzymes on-demand GSH-consuming ability in tumor cells, accelerating selective safe ferroptosis. antitumor response been demonstrated colon breast cancer, promoting development

Language: Английский

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Triple-synergistic MOF-nanozyme for efficient antibacterial treatment

Bioactive Materials, Journal Year: 2022, Volume and Issue: 17, P. 289 - 299

Published: Feb. 1, 2022

The abuse of antibiotics makes bacterial infection an increasingly serious global health threat. Reactive oxygen species (ROS) are the ideal alternative antibacterial approach for quick and effective sterilization. Although various strategies based on ROS have been developed, many them still limited by insufficient efficiency. Here, we developed acid-enhanced dual-modal strategy zeolitic imidazolate frameworks-8 (ZIF8) -derived nanozyme. ZIF8, which can release Zn

Language: Английский

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A Molybdenum Disulfide Nanozyme with Charge‐Enhanced Activity for Ultrasound‐Mediated Cascade‐Catalytic Tumor Ferroptosis

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 62(11)

Published: Dec. 31, 2022

Abstract The deficient catalytic activity of nanozymes and insufficient endogenous H 2 O in the tumor microenvironment (TME) are major obstacles for nanozyme‐mediated therapy. Since electron transfer is basic essence catalysis‐mediated redox reactions, we explored contributing factors enzymatic based on positive negative charges, which experimentally theoretically demonstrated to enhance peroxidase (POD)‐like a MoS nanozyme. Hence, an acidic microenvironment‐responsive ultrasound‐mediated cascade nanocatalyst (BTO/MoS @CA) presented that made from few‐layer nanosheets grown surface piezoelectric tetragonal barium titanate (T‐BTO) modified with pH‐responsive cinnamaldehyde (CA). integration CA‐mediated self‐supply, charge‐enhanced activity, glutathione (GSH) depletion enables out‐of‐balance homeostasis, leading effective ferroptosis minimal side effects.

Language: Английский

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Reviving Zn⁰ Dendrites to Electroactive Zn²⁺ by Mesoporous MXene with Active Edge Sites

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(44), P. 24284 - 24293

Published: Oct. 27, 2023

Zinc metal-based aqueous batteries (ZABs) offer a sustainable, affordable, and safe energy storage alternative to lithium, yet inevitable dendrite formation impedes their wide use, especially under long-term high-rate cycles. How the battery can survive after remains an open question. Here, we pivot from conventional Zn growth suppression strategies, introducing proactive dendrite-digesting chemistry via mesoporous Ti3C2 MXene (MesoTi3C2)-wrapped polypropylene separator. Spectroscopic characterizations electrochemical evaluation demonstrate that MesoTi3C2, acting as oxidant, revive formed dead Zn0 dendrites into electroactive Zn2+ ions through spontaneous redox process. Density functional theory reveals abundant edge-Ti-O sites in our MesoTi3C2 facilitate high oxidizability electron transfer compared in-plane counterparts. The resultant asymmetrical cell demonstrates remarkable ultralong cycle life of 2200 h at practical current 5 mA cm-2 with low overpotential (<50 mV). study unexpected edge effect MXenes uncovers new ZABs, albeit formation.

Language: Английский

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Nano–Bio Interactions: Biofilm‐Targeted Antibacterial Nanomaterials

Small, Journal Year: 2023, Volume and Issue: 20(7)

Published: Oct. 6, 2023

Abstract Biofilm is a spatially organized community formed by the accumulation of both microorganisms and their secretions, leading to persistent chronic infections because high resistance toward conventional antibiotics. In view tunable physicochemical properties related unique biological behavior (e.g., size‐, shape‐, surface charge‐dependent penetration, protein corona endowed targeting, catalytic‐ electronic‐related oxidative stress, optical‐ magnetic‐associated hyperthermia, etc.), nanomaterials‐based therapeutics are widely used for treatment biofilm‐associated infections. this review, characteristics biofilm introduced. And antibacterial strategies further discussed via including preventing formation, enhancing disrupting mature biofilm, acting as drug delivery systems. which, interactions between nanomaterials include mechanical disruption, electron transfer, enzymatic degradation, hyperthermia. Additionally, current advances targeting summarized. This review aims present complete vision nanomaterials–biofilm (nano–bio) interactions, paving way future development clinical translation effective nanomedicines.

Language: Английский

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Molybdenum-based antimicrobial nanomaterials: A comprehensive review

Nano Today, Journal Year: 2023, Volume and Issue: 50, P. 101875 - 101875

Published: May 17, 2023

Language: Английский

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Targeting and arginine-driven synergizing photodynamic therapy with nutritional immunotherapy nanosystems for combating MRSA biofilms

Science Advances, Journal Year: 2023, Volume and Issue: 9(28)

Published: July 14, 2023

The resistance and immune escape of methicillin-resistant Staphylococcus aureus (MRSA) biofilms cause recalcitrant infections. Here, we design a targeting synergizing cascade PDT with nutritional immunotherapy nanosystems (Arg-PCN@Gel) containing PCN-224 as platform for providing reactive oxygen species (ROS), incorporating arginine (Arg) nitric oxide (NO) donor to ROS produce more lethal ONOO − promote response, coating gelatin agent persistent Arg provider. adhered the autolysin MRSA inhibited metabolism by down-regulating icdA icaA . It suppressed polysaccharide intercellular adhesin extracellular DNA synthesis prevent biofilm formation. NO broke mature helped penetrate into inactivate internal MRSA. Arg-PCN@Gel drove enhance immunity via inducible synthase/NO axis arginase/polyamine achieve efficient target treatment in cascading synergized provide an effective promising strategy biofilm-associated

Language: Английский

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