Micromachines,
Journal Year:
2023,
Volume and Issue:
14(7), P. 1326 - 1326
Published: June 28, 2023
Optical
tweezers
(OTs)
can
transfer
light
momentum
to
particles,
achieving
the
precise
manipulation
of
particles
through
optical
forces.
Due
properties
non-contact
and
control,
OTs
have
provided
a
gateway
for
exploring
mysteries
behind
nonlinear
optics,
soft-condensed-matter
physics,
molecular
biology,
analytical
chemistry.
In
recent
years,
been
combined
with
microfluidic
chips
overcome
their
limitations
in,
instance,
speed
efficiency,
creating
technology
known
as
“optofluidic
tweezers.”
This
paper
describes
static
briefly
first.
Next,
we
overview
developments
in
optofluidic
tweezers,
summarizing
advancements
capture,
manipulation,
sorting,
measurement
based
on
different
technologies.
The
focus
is
various
kinds
such
holographic
photonic-crystal
waveguide
tweezers.
Moreover,
there
continuing
trend
combining
other
techniques
achieve
greater
functionality,
antigen–antibody
interactions
Raman
We
conclude
by
main
challenges
future
directions
this
research
field.
Theranostics,
Journal Year:
2022,
Volume and Issue:
12(4), P. 1870 - 1903
Published: Jan. 1, 2022
Surface-enhanced
Raman
scattering
(SERS)
has
emerged
as
a
valuable
technique
for
molecular
identification.
Due
to
the
characteristics
of
high
sensitivity,
excellent
signal
specificity,
and
photobleaching
resistance,
SERS
been
widely
used
in
fields
environmental
monitoring,
food
safety,
disease
diagnosis.
By
attaching
organic
molecules
surface
plasmonic
nanoparticles,
obtained
tags
show
high-performance
multiplexing
capability
biosensing.
The
past
decade
witnessed
progress
liquid
biopsy,
bioimaging,
theranostics
applications.
This
review
focuses
on
advances
biomedical
fields.
We
first
introduce
building
blocks
tags,
followed
by
summarization
recent
employed
detecting
biomarkers,
such
DNA,
miRNA,
protein
biological
fluids,
well
imaging
from
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(22), P. 14000 - 14019
Published: May 20, 2024
While
surface-enhanced
Raman
spectroscopy
(SERS)
has
experienced
substantial
advancements
since
its
discovery
in
the
1970s,
it
is
an
opportunity
to
celebrate
achievements,
consider
ongoing
endeavors,
and
anticipate
future
trajectory
of
SERS.
In
this
perspective,
we
encapsulate
latest
breakthroughs
comprehending
electromagnetic
enhancement
mechanisms
SERS,
revisit
CT
semiconductors.
We
then
summarize
strategies
improve
sensitivity,
selectivity,
reliability.
After
addressing
experimental
advancements,
comprehensively
survey
progress
on
spectrum–structure
correlation
SERS
showcasing
their
important
role
promoting
development.
Finally,
forthcoming
directions
opportunities,
especially
deepening
our
insights
into
chemical
or
biological
processes
establishing
a
clear
correlation.
Opto-Electronic Advances,
Journal Year:
2022,
Volume and Issue:
5(10), P. 210121 - 210121
Published: Jan. 1, 2022
Surface-enhanced
Raman
scattering
(SERS),
owing
to
its
high
sensitivity
based
on
localized
surface
plasmon
resonance
of
nanostructured
metals,
is
recently
attracting
much
attention
be
used
for
biotechnology,
such
as
cell
imaging
and
tumor
therapy.
On
the
other
hand,
trace
detection
bio-molecules
with
large
molecular
weight
still
challenging
because
troublesome
treatment
SERS
substrate
using
coupling
or
cross-linking
agents
required.
In
this
paper,
we
apply
liquid
interface
assisted
(LI-SERS)
method,
which
provides
unique
features
collection
self-immobilization
analyte
molecules
substrate,
realize
label-free
limits
pM
~
fM.
Specifically,
deoxyribonucleic
acid
(DNA)
discrimination
quantitative
β-Amyloid
(Aβ)
in
trace-concentration
are
demonstrated
illustrate
ultrahigh
versatility
LI-SERS
method.
The
results
suggest
promising
early-stage
diagnosis
diseases
virus
infection
Alzheimer's
disease.
Comprehensive Reviews in Food Science and Food Safety,
Journal Year:
2023,
Volume and Issue:
22(3), P. 1466 - 1494
Published: March 1, 2023
Abstract
Rapid
control
and
prevention
of
diseases
caused
by
foodborne
pathogens
is
one
the
existing
food
safety
regulatory
issues
faced
various
countries
has
received
wide
attention
from
all
sectors
society.
The
development
rapid
reliable
detection
methods
for
remains
a
hot
research
area
public
health
because
limitations
complex
steps,
time‐consuming,
low
sensitivity,
or
poor
selectivity
commonly
used
methods.
Surface‐enhanced
Raman
spectroscopy
(SERS),
as
novel
spectroscopic
technique,
advantages
high
selectivity,
nondestructive
exhibited
broad
application
prospects
in
determination
pathogenic
bacteria.
In
this
study,
enhancement
mechanisms
SERS
are
briefly
introduced,
then
characteristics
properties
liquid‐phase,
rigid
solid‐phase,
flexible
solid‐phase
categorized.
Furthermore,
comprehensive
review
advances
label‐free
label‐based
strategies
SERS‐compatible
techniques
provided,
disadvantages
these
reviewed.
Finally,
current
challenges
technology
applied
practical
applications
listed,
possible
trends
field
future
discussed.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(5), P. 3916 - 3968
Published: Jan. 23, 2024
Dynamic
variations
in
the
concentration
and
abnormal
distribution
of
endogenous
biomarkers
are
strongly
associated
with
multiple
physiological
pathological
states.
Therefore,
it
is
crucial
to
design
imaging
systems
capable
real-time
detection
dynamic
changes
for
accurate
diagnosis
effective
treatment
diseases.
Recently,
ratiometric
has
emerged
as
a
widely
used
technique
sensing
due
its
advantage
circumventing
limitations
inherent
conventional
intensity-dependent
signal
readout
methods
while
also
providing
built-in
self-calibration
correction.
Here,
recent
progress
probes
their
applications
outlined.
Ratiometric
classified
according
mechanisms,
photoacoustic
imaging,
optical
including
photoluminescence
self-luminescence
magnetic
resonance
dual-modal
discussed.
The
such
pH,
reactive
oxygen
species
(ROS),
nitrogen
(RNS),
glutathione
(GSH),
gas
molecules,
enzymes,
metal
ions,
hypoxia
discussed
detail.
Additionally,
this
Review
presents
an
overview
challenges
faced
field
along
future
research
directions.
The
year
2024
marks
the
50th
anniversary
of
discovery
surface-enhanced
Raman
spectroscopy
(SERS).
Over
recent
years,
SERS
has
experienced
rapid
development
and
became
a
critical
tool
in
biomedicine
with
its
unparalleled
sensitivity
molecular
specificity.
This
review
summarizes
advancements
challenges
substrates,
nanotags,
instrumentation,
spectral
analysis
for
biomedical
applications.
We
highlight
key
developments
colloidal
solid
an
emphasis
on
surface
chemistry,
hotspot
design,
3D
hydrogel
plasmonic
architectures.
Additionally,
we
introduce
innovations
including
those
interior
gaps,
orthogonal
reporters,
near-infrared-II-responsive
properties,
along
biomimetic
coatings.
Emerging
technologies
such
as
optical
tweezers,
nanopores,
wearable
sensors
have
expanded
capabilities
single-cell
single-molecule
analysis.
Advances
analysis,
signal
digitalization,
denoising,
deep
learning
algorithms,
improved
quantification
complex
biological
data.
Finally,
this
discusses
applications
nucleic
acid
detection,
protein
characterization,
metabolite
monitoring,
vivo
spectroscopy,
emphasizing
potential
liquid
biopsy,
metabolic
phenotyping,
extracellular
vesicle
diagnostics.
concludes
perspective
clinical
translation
SERS,
addressing
commercialization
potentials
tissue
sensing
imaging.
ACS Sensors,
Journal Year:
2021,
Volume and Issue:
6(11), P. 3912 - 3932
Published: Nov. 2, 2021
Early
specific
detection
through
indicative
biomarkers
and
precise
visualization
of
lesion
sites
are
urgent
requirements
for
clinical
disease
diagnosis.
However,
current
optical
imaging
methods
insufficient
these
demands.
Molecular
technologies
being
intensely
studied
reliable
medical
In
the
past
several
decades,
molecular
with
surface-enhanced
Raman
scattering
(SERS)
has
significant
advances
from
analytical
chemistry
to
science.
SERS
is
inelastic
generated
interaction
between
photons
substances,
presenting
structure
information.
The
outstanding
virtues
high
sensitivity,
specificity,
resistance
biointerference
highly
advantageous
biomarker
in
a
complex
biological
matrix.
this
work,
we
review
recent
progress
on
applications
diagnostics.
With
assistance
imaging,
disease-related
proteins,
nucleic
acids,
small
molecules,
pH
cellular
microenvironment
can
be
implemented
adjuvant
Moreover,
multimodal
integrates
penetration
speed
other
modalities
precision
resulting
final
complete
accurate
outcomes
exhibiting
robust
potential
discrimination
pathological
tissues
surgical
navigation.
As
promising
technology,
achieved
remarkable
performance
diagnostics
biomedical
realm.
It
expected
that
will
provide
insights
further
development
promote
rapid
successful
translation
advanced
