Gels,
Journal Year:
2022,
Volume and Issue:
8(10), P. 606 - 606
Published: Sept. 21, 2022
Hydrogels
have
been
extensively
used
as
scaffolds
in
tissue
engineering
for
cell
adhesion,
proliferation,
migration,
and
differentiation
because
of
their
high-water
content
biocompatibility
similarity
to
the
extracellular
matrix.
However,
submicron
or
nanosized
pore
networks
within
hydrogels
severely
limit
survival
regeneration.
In
recent
years,
application
macroporous
has
received
considerable
attention.
The
structure
not
only
facilitates
nutrient
transportation
metabolite
discharge
but
also
provides
more
space
behavior
formation.
Several
strategies
creating
functionalizing
reported.
This
review
began
with
an
overview
advantages
challenges
regulation
cellular
behavior.
addition,
advanced
methods
preparation
modulate
were
discussed.
Finally,
future
research
related
fields
was
Signal Transduction and Targeted Therapy,
Journal Year:
2025,
Volume and Issue:
10(1)
Published: March 7, 2025
Abstract
Macrophages
are
immune
cells
belonging
to
the
mononuclear
phagocyte
system.
They
play
crucial
roles
in
defense,
surveillance,
and
homeostasis.
This
review
systematically
discusses
types
of
hematopoietic
progenitors
that
give
rise
macrophages,
including
primitive
progenitors,
erythro-myeloid
stem
cells.
These
have
distinct
genetic
backgrounds
developmental
processes.
Accordingly,
macrophages
exhibit
complex
diverse
functions
body,
phagocytosis
clearance
cellular
debris,
antigen
presentation,
response,
regulation
inflammation
cytokine
production,
tissue
remodeling
repair,
multi-level
regulatory
signaling
pathways/crosstalk
involved
homeostasis
physiology.
Besides,
tumor-associated
a
key
component
TME,
exhibiting
both
anti-tumor
pro-tumor
properties.
Furthermore,
functional
status
is
closely
linked
development
various
diseases,
cancer,
autoimmune
disorders,
cardiovascular
disease,
neurodegenerative
metabolic
conditions,
trauma.
Targeting
has
emerged
as
promising
therapeutic
strategy
these
contexts.
Clinical
trials
macrophage-based
targeted
drugs,
immunotherapies,
nanoparticle-based
therapy
were
comprehensively
summarized.
Potential
challenges
future
directions
targeting
also
been
discussed.
Overall,
our
highlights
significance
this
versatile
cell
human
health
which
expected
inform
research
clinical
practice.
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Feb. 25, 2025
Cancer
stem
cells
(CSCs)
are
central
to
tumor
progression,
metastasis,
immune
evasion,
and
therapeutic
resistance.
Characterized
by
remarkable
self-renewal
adaptability,
CSCs
can
transition
dynamically
between
stem-like
differentiated
states
in
response
external
stimuli,
a
process
termed
"CSC
plasticity."
This
adaptability
underpins
their
resilience
therapies,
including
checkpoint
inhibitors
adoptive
cell
therapies
(ACT).
Beyond
intrinsic
properties,
reside
specialized
microenvironment—the
CSC
niche—which
provides
immune-privileged
protection,
sustains
stemness,
fosters
suppression.
review
highlights
the
critical
role
of
niche
driving
immunotherapy
resistance,
emphasizing
need
for
integrative
approaches
overcome
these
challenges.
Gels,
Journal Year:
2022,
Volume and Issue:
8(10), P. 606 - 606
Published: Sept. 21, 2022
Hydrogels
have
been
extensively
used
as
scaffolds
in
tissue
engineering
for
cell
adhesion,
proliferation,
migration,
and
differentiation
because
of
their
high-water
content
biocompatibility
similarity
to
the
extracellular
matrix.
However,
submicron
or
nanosized
pore
networks
within
hydrogels
severely
limit
survival
regeneration.
In
recent
years,
application
macroporous
has
received
considerable
attention.
The
structure
not
only
facilitates
nutrient
transportation
metabolite
discharge
but
also
provides
more
space
behavior
formation.
Several
strategies
creating
functionalizing
reported.
This
review
began
with
an
overview
advantages
challenges
regulation
cellular
behavior.
addition,
advanced
methods
preparation
modulate
were
discussed.
Finally,
future
research
related
fields
was
