Horticulture Research, Journal Year: 2022, Volume and Issue: 9
Published: Jan. 1, 2022
Language: Английский
Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13
Published: Nov. 25, 2022
Traditional Chinese Medicine (TCM) is extensively utilized in clinical practice due to its therapeutic and preventative treatments for various diseases. With the development of high-throughput sequencing systems biology, TCM research was transformed from traditional experiment-based approaches a combination omics-based approaches. Numerous academics have explored mechanism formula by omics approaches, shifting "one-target, one-drug" "multi-targets, multi-components" paradigm, which has greatly boosted digitalization internationalization TCM. In this review, we concentrated on multi-omics principles applications gain better understanding formulas against diseases several aspects. We first summarized frequently used quality assessment methods, suggested that incorporating both chemical biological ingredients analytical methods could lead more comprehensive Secondly, emphasized significance deciphering formulas. Thirdly, focused network analysis, plays vital role TCM-diseases interaction, serves new drug discovery. Finally, as an essential source storing data, evaluated compared databases terms completeness reliability. summary, infiltrated many aspects research. accumulation data data-mining resources, deeper understandings been acquired or will be gained future.
Language: Английский
Citations
36
Plant Communications, Journal Year: 2022, Volume and Issue: 3(2), P. 100300 - 100300
Published: Jan. 20, 2022
Plants produce a remarkable diversity of structurally and functionally diverse natural chemicals that serve as adaptive compounds throughout their life cycles. However, unlocking this metabolic is significantly impeded by the size, complexity, abundant repetitive elements typical plant genomes. As genome sequencing becomes routine, we anticipate links between genetic variation will be strengthened. In addition, an ever-increasing number genomes have revealed biosynthetic gene clusters are not only hallmark microbes fungi; for various classes also been found in plants, many associated with important agronomic traits. We present recent examples diversification discovered through exploration exploitation genomic pan-genomic data. draw attention to fundamental basis chemodiversity discuss challenges future perspectives investigating coming pan-genomics era.
Language: Английский
Citations
32
Computational and Structural Biotechnology Journal, Journal Year: 2022, Volume and Issue: 20, P. 3248 - 3256
Published: Jan. 1, 2022
Whole-genome duplication (WGD) has occurred repeatedly during plant evolution and diversification, providing genetic layers for evolving new functions phenotypes. Advances in long-read sequencing technologies have enabled assembly of over 1000 genomes spanning nearly 800 species, which a large set ancient WGDs been uncovered. Here, we review the recently reported that major lineages key evolutionary positions, highlight their contributions to morphological innovation adaptive evolution. Current gaps challenges integrating enormous volumes sequenced genomes, accurately inferring WGDs, developing web-based analysis tools are emphasized. Looking future, ambitious genome projects global efforts may substantially recapitulate tree life based on broader sampling phylogenetic diversity, reveal much timetable address biological significance adaptation radiation.
Language: Английский
Citations
30
Plant Physiology and Biochemistry, Journal Year: 2023, Volume and Issue: 204, P. 108125 - 108125
Published: Oct. 19, 2023
Language: Английский
Citations
21
Molecular Plant, Journal Year: 2023, Volume and Issue: 17(1), P. 158 - 177
Published: Nov. 10, 2023
Language: Английский
Citations
21
Chinese Medicine, Journal Year: 2023, Volume and Issue: 18(1)
Published: June 6, 2023
Traditional Chinese medicine (TCM) has been used for centuries to prevent and treat a variety of illnesses, its popularity is increasing worldwide. However, the clinical applications natural active components in TCM are hindered by poor solubility low bioavailability these compounds. To address issues, self-assembly nanostrategy (CSAN) being developed. Many possess properties, allowing them form nanoparticles (NPs) through various noncovalent forces. Self-assembled NPs (SANs) also present decoctions, they closely linked therapeutic effects remedies. SAN gaining nano research field due simplicity, eco-friendliness, enhanced biodegradability biocompatibility compared traditional preparation methods. The ingredients from that exhibit antitumour or combined with other drugs generated considerable interest cancer therapeutics. This paper provides review principles forms CSAN, as well an overview recent reports on can be self-assembly. Additionally, application CSAN diseases summarized, finally, concluding summary thoughts proposed. We strongly believe potential offer fresh strategies perspectives modernization TCM.
Language: Английский
Citations
20
Plant Communications, Journal Year: 2023, Volume and Issue: 5(1), P. 100677 - 100677
Published: Aug. 26, 2023
Rheum officinale, a member of the Polygonaceae family, is an important medicinal plant used widely in traditional Chinese medicine. Here, we report 7.68 Gb chromosome-scale assembly R. officinale with contig N50 3.47 Mb, further clustered into 44 chromosomes across four homologous groups. Comparative genomics analysis revealed that transposable elements contribute significantly to genome evolution, gene copy number variation and regulation expression involved mainly metabolite biosynthesis, stress resistance root development officinale. We determined recently doubled autotetraploid at ∼0.58 Mya analyzed genomic features between chromosomes. Although no dominant monoploid genomes were observed overall level, numerous allele-differential expressed genes, mostly different insertions their regulatory regions, identified, suggesting functional divergence after polyploidization. Combining genomics, transcriptomics metabolomics, explored contributions family amplification tetraploidization abundant production anthraquinone, patterns differences anthraquinone content among tissues As autopolyploid herbs, our offers unprecedented resources for fundamental research guidance polyploidy breeding herbs.
Language: Английский
Citations
20
Biotechnology Advances, Journal Year: 2023, Volume and Issue: 69, P. 108258 - 108258
Published: Sept. 16, 2023
Language: Английский
Citations
20
Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)
Published: Feb. 20, 2023
Benzylisoquinoline alkaloids (BIAs) are a structurally diverse group of plant specialized metabolites found mainly in members the order Ranunculales, including opium poppy (Papaver somniferum), for which BIA biosynthetic pathways leading to critical drugs morphine, noscapine, and sanguinarine have been elucidated. Sacred lotus (Nelumbo nucifera), Proteales, accumulates medicinal BIAs proaporphine, aporphine, bisbenzylisoquinoline structural subgroups with prevalence R enantiomers, opposed dominant S configuration occurring Ranunculales. Nevertheless, distinctive routes sacred not explored. In planta labeling experiments vitro assays recombinant enzymes protein extracts showed that dopamine 4-hydroxyphenylacetaldehyde derived from L-tyrosine serve as precursors formation (R,S)-norcoclaurine lotus, whereas only (R)-norcoclaurine byproducts favored by action R-enantiospecific methyltransferases cytochrome P450 oxidoreductases (CYPs). Enzymes responsible proaporphine (NnCYP80Q1) (NnCYP80Q2) scaffolds, methylenedioxy bridge introduction on aporphine substrates (NnCYP719A22) were identified, additional aspects alkaloid profile discussed. This work expands availability molecular tools can be deployed synthetic biology platforms production high-value alkaloids.
Language: Английский
Citations
19
Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 668, P. 132 - 141
Published: April 23, 2024
Language: Английский
Citations
7