Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Nov. 9, 2022
Growing
evidence
links
COVID-19
with
acute
and
long-term
neurological
dysfunction.
However,
the
pathophysiological
mechanisms
resulting
in
central
nervous
system
involvement
remain
unclear,
posing
both
diagnostic
therapeutic
challenges.
Here
we
show
outcomes
of
a
cross-sectional
clinical
study
(NCT04472013)
including
imaging
data
corresponding
multidimensional
characterization
immune
mediators
cerebrospinal
fluid
(CSF)
plasma
patients
belonging
to
different
Neuro-COVID
severity
classes.
The
most
prominent
signs
severe
are
blood-brain
barrier
(BBB)
impairment,
elevated
microglia
activation
markers
polyclonal
B
cell
response
targeting
self-antigens
non-self-antigens.
decreased
regional
brain
volumes
associating
specific
CSF
parameters,
however,
characterized
by
cytokine
storm
presenting
non-inflammatory
profile.
Post-acute
syndrome
strongly
associates
distinctive
set
mediators.
Collectively,
identify
several
potentially
actionable
targets
prevent
or
intervene
consequences
SARS-CoV-2
infection.
Cell,
Journal Year:
2022,
Volume and Issue:
185(5), P. 881 - 895.e20
Published: Jan. 25, 2022
Post-acute
sequelae
of
COVID-19
(PASC)
represent
an
emerging
global
crisis.
However,
quantifiable
risk
factors
for
PASC
and
their
biological
associations
are
poorly
resolved.
We
executed
a
deep
multi-omic,
longitudinal
investigation
309
patients
from
initial
diagnosis
to
convalescence
(2-3
months
later),
integrated
with
clinical
data
patient-reported
symptoms.
resolved
four
PASC-anticipating
at
the
time
diagnosis:
type
2
diabetes,
SARS-CoV-2
RNAemia,
Epstein-Barr
virus
viremia,
specific
auto-antibodies.
In
gastrointestinal
PASC,
SARS-CoV-2-specific
CMV-specific
CD8+
T
cells
exhibited
unique
dynamics
during
recovery
COVID-19.
Analysis
symptom-associated
immunological
signatures
revealed
coordinated
immunity
polarization
into
endotypes,
exhibiting
divergent
acute
severity
PASC.
find
that
between
diminish
over
time,
leading
distinct
convalescent
immune
states.
Detectability
most
emphasizes
importance
early
disease
measurements
understanding
emergent
chronic
conditions
suggests
treatment
strategies.
Science,
Journal Year:
2022,
Volume and Issue:
375(6585), P. 1122 - 1127
Published: March 10, 2022
Considerable
research
effort
has
been
made
worldwide
to
decipher
the
immune
response
triggered
upon
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
infections,
identify
drivers
of
and
fatal
COVID-19,
understand
what
leads
prolongation
symptoms
after
disease
resolution.
We
review
results
almost
years
COVID-19
immunology
discuss
definitive
findings
remaining
questions
regarding
our
understanding
pathophysiology.
emerging
differences
in
responses
seen
those
with
without
Long
Covid
syndrome,
also
known
as
post-acute
sequelae
SARS-CoV-2.
hope
that
knowledge
gained
from
this
will
be
applied
studies
inflammatory
processes
involved
critical
chronic
illnesses,
which
remain
a
major
unmet
need.
The Journal of Infectious Diseases,
Journal Year:
2021,
Volume and Issue:
224(11), P. 1839 - 1848
Published: Sept. 24, 2021
The
biological
processes
associated
with
postacute
sequelae
of
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
infection
(PASC)
are
unknown.
Science,
Journal Year:
2024,
Volume and Issue:
383(6680)
Published: Jan. 18, 2024
Long
Covid
is
a
debilitating
condition
of
unknown
etiology.
We
performed
multimodal
proteomics
analyses
blood
serum
from
COVID-19
patients
followed
up
to
12
months
after
confirmed
severe
acute
respiratory
syndrome
coronavirus
2
infection.
Analysis
>6500
proteins
in
268
longitudinal
samples
revealed
dysregulated
activation
the
complement
system,
an
innate
immune
protection
and
homeostasis
mechanism,
individuals
experiencing
Covid.
Thus,
active
was
characterized
by
terminal
system
dysregulation
ongoing
alternative
classical
pathways,
latter
associated
with
increased
antibody
titers
against
several
herpesviruses
possibly
stimulating
this
pathway.
Moreover,
markers
hemolysis,
tissue
injury,
platelet
activation,
monocyte-platelet
aggregates
were
Machine
learning
thromboinflammatory
as
top
biomarkers,
warranting
diagnostic
therapeutic
interrogation
these
systems.
Proceedings of the National Academy of Sciences,
Journal Year:
2022,
Volume and Issue:
119(21)
Published: May 16, 2022
Significance
There
is
growing
evidence
that
preexisting
autoantibodies
neutralizing
type
I
interferons
(IFNs)
are
strong
determinants
of
life-threatening
COVID-19
pneumonia.
It
important
to
estimate
their
quantitative
impact
on
mortality
upon
SARS-CoV-2
infection,
by
age
and
sex,
as
both
the
prevalence
these
risk
death
increase
with
higher
in
men.
Using
an
unvaccinated
sample
1,261
deceased
patients
34,159
individuals
from
general
population,
we
found
against
IFNs
strongly
increased
infection
fatality
rate
at
all
ages,
men
women.
Autoantibodies
common
predictors
COVID-19.
Testing
for
should
be
considered
population.
Journal of Translational Medicine,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: March 16, 2022
Abstract
Autoimmunity
has
emerged
as
a
characteristic
of
the
post-COVID
syndrome
(PCS),
which
may
be
related
to
sex.
In
order
further
investigate
relationship
between
SARS-CoV-2
and
autoimmunity
in
PCS,
clinical
serological
assessment
on
100
patients
was
done.
Serum
antibody
profiles
against
self-antigens
infectious
agents
were
evaluated
by
an
antigen
array
chip
for
116
IgG
104
IgM
antibodies.
Thirty
pre-pandemic
healthy
individuals
included
control
group.
The
median
age
49
years
(IQR:
37.8
55.3).
There
47
males.
time
219
143
258)
days.
Latent
polyautoimmunity
found
83%
62%
patients,
respectively.
Three
developed
overt
autoimmune
disease.
antibodies
IL-2,
CD8B,
thyroglobulin
more
than
10%
patients.
Other
autoantibodies,
such
anti-interferons,
positive
5–10%
Anti-SARS-CoV-2
>
85%
positively
correlated
with
age,
body
mass
index
(BMI).
Few
autoantibodies
influenced
BMI.
no
effect
gender
over-
or
under-expression
autoantibodies.
anti-IFN-λ
associated
persistence
respiratory
symptoms.
summary,
is
latent
correlates
humoral
response
SARS-CoV-2.
