The Pathophysiology of Long COVID throughout the Renin-Angiotensin System DOI Creative Commons

Shaymaa Khazaal,

Julien Harb,

Mohamad Rima

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(9), P. 2903 - 2903

Published: May 2, 2022

COVID-19 has expanded across the world since its discovery in Wuhan (China) and had a significant impact on people's lives health. Long COVID is term coined by World Health Organization (WHO) to describe variety of persistent symptoms after acute SARS-CoV-2 infection. been demonstrated affect various SARS-CoV-2-infected persons, independently disease severity. The long COVID, like COVID-19, consist set damage organs systems such as respiratory, cardiovascular, neurological, endocrine, urinary, immune systems. Fatigue, dyspnea, cardiac abnormalities, cognitive attention impairments, sleep disturbances, post-traumatic stress disorder, muscle pain, concentration problems, headache were all reported COVID. At molecular level, renin-angiotensin system (RAS) heavily involved pathogenesis this illness, much it phase viral In review, we summarize several tissues, with special focus significance RAS pathogenesis. risk factors potential therapy approaches are also explored.

Language: Английский

Unexplained post-acute infection syndromes DOI Open Access
Jan Choutka,

Viraj Jansari,

Mady Hornig

et al.

Nature Medicine, Journal Year: 2022, Volume and Issue: 28(5), P. 911 - 923

Published: May 1, 2022

Language: Английский

Citations

423
The IL-1β, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19 DOI
Christoph Schultheiß, Edith Willscher, Lisa Paschold

et al.

Cell Reports Medicine, Journal Year: 2022, Volume and Issue: 3(6), P. 100663 - 100663

Published: June 1, 2022

Language: Английский

Citations

320
The immunology of long COVID DOI Open Access
Daniel M. Altmann, Emily M. Whettlock, Siyi Liu

et al.

Nature reviews. Immunology, Journal Year: 2023, Volume and Issue: 23(10), P. 618 - 634

Published: July 11, 2023

Language: Английский

Citations

265
Distinguishing features of Long COVID identified through immune profiling DOI Open Access
Jon Klein, Jamie Wood, Jillian R. Jaycox

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: Aug. 10, 2022

SARS-CoV-2 infection can result in the development of a constellation persistent sequelae following acute disease called post-acute COVID-19 (PASC) or Long COVID 1-3 . Individuals diagnosed with frequently report unremitting fatigue, post-exertional malaise, and variety cognitive autonomic dysfunctions ; however, basic biological mechanisms responsible for these debilitating symptoms are unclear. Here, 215 individuals were included an exploratory, cross-sectional study to perform multi-dimensional immune phenotyping conjunction machine learning methods identify key immunological features distinguishing COVID. Marked differences noted specific circulating myeloid lymphocyte populations relative matched control groups, as well evidence elevated humoral responses directed against among participants Further, unexpected increases observed antibody non-SARS-CoV-2 viral pathogens, particularly Epstein-Barr virus. Analysis mediators various hormones also revealed pronounced differences, levels cortisol being uniformly lower groups. Integration data into unbiased models identified significant critical accurate classification COVID, decreased most individual predictor. These findings will help guide additional studies pathobiology may aid future objective biomarkers

Language: Английский

Citations

198
Innate immune evasion strategies of SARS-CoV-2 DOI Open Access
Judith M. Minkoff, Benjamin R. tenOever

Nature Reviews Microbiology, Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 11, 2023

Language: Английский

Citations

167
The development of COVID-19 treatment DOI Creative Commons

Yongliang Yuan,

Baihai Jiao, Lili Qu

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Jan. 26, 2023

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a pandemic named disease 2019 (COVID-19) that has become the greatest worldwide public health threat this century. Recent studies have unraveled numerous mysteries SARS-CoV-2 pathogenesis and thus largely improved COVID-19 vaccines therapeutic strategies. However, important questions remain regarding its therapy. In review, recent research advances on mechanism are quickly summarized. We mainly discuss current therapy strategies for COVID-19, with an emphasis antiviral agents, neutralizing antibody therapies, Janus kinase inhibitors, steroids. When necessary, specific mechanisms history present, representative described in detail. Finally, we key outstanding future directions development treatment.

Language: Английский

Citations

167
Pathogenic mechanisms of post-acute sequelae of SARS-CoV-2 infection (PASC) DOI Creative Commons
Zaki A. Sherif, Christian R. Gómez, Thomas J. Connors

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: March 22, 2023

COVID-19, with persistent and new onset of symptoms such as fatigue, post-exertional malaise, cognitive dysfunction that last for months impact everyday functioning, is referred to Long COVID under the general category post-acute sequelae SARS-CoV-2 infection (PASC). PASC highly heterogenous may be associated multisystem tissue damage/dysfunction including acute encephalitis, cardiopulmonary syndromes, fibrosis, hepatobiliary damages, gastrointestinal dysregulation, myocardial infarction, neuromuscular neuropsychiatric disorders, pulmonary damage, renal failure, stroke, vascular endothelial dysregulation. A better understanding pathophysiologic mechanisms underlying essential guide prevention treatment. This review addresses potential hypotheses connect long-term health consequences. Comparisons between other virus-initiated chronic syndromes myalgic encephalomyelitis/chronic fatigue syndrome postural orthostatic tachycardia will addressed. Aligning identifying potentially regulated common underlining pathways necessary true nature PASC. The discussed contributors include from injury one or more organs, reservoirs replicating virus its remnants in several tissues, re-activation latent pathogens Epstein-Barr herpes viruses COVID-19 immune-dysregulated environment, interactions host microbiome/virome communities, clotting/coagulation dysfunctional brainstem/vagus nerve signaling, dysautonomia autonomic dysfunction, ongoing activity primed immune cells, autoimmunity due molecular mimicry pathogen proteins. individualized suggests different therapeutic approaches required best manage specific patients.

Language: Английский

Citations

154
Data-driven identification of post-acute SARS-CoV-2 infection subphenotypes DOI Creative Commons
Hao Zhang, Chengxi Zang, Zhenxing Xu

et al.

Nature Medicine, Journal Year: 2022, Volume and Issue: 29(1), P. 226 - 235

Published: Dec. 1, 2022

Abstract The post-acute sequelae of SARS-CoV-2 infection (PASC) refers to a broad spectrum symptoms and signs that are persistent, exacerbated or newly incident in the period after acute infection. Most studies have examined these conditions individually without providing evidence on co-occurring conditions. In this study, we leveraged electronic health record data two large cohorts, INSIGHT OneFlorida+, from national Patient-Centered Clinical Research Network. We created development cohort validation OneFlorida+ including 20,881 13,724 patients, respectively, who were infected, investigated their diagnoses 30–180 days documented Through machine learning analysis over 137 conditions, identified four reproducible PASC subphenotypes, dominated by cardiac renal (including 33.75% 25.43% patients cohorts); respiratory, sleep anxiety (32.75% 38.48%); musculoskeletal nervous system (23.37% 23.35%); digestive respiratory (10.14% 12.74%) sequelae. These subphenotypes associated with distinct patient demographics, underlying before phase severity. Our study provides insights into heterogeneity may inform stratified decision-making management

Language: Английский

Citations

148
Multimodal neuroimaging in post-COVID syndrome and correlation with cognition DOI
María Díez‐Cirarda, Miguel Yus, Natividad Gómez‐Ruiz

et al.

Brain, Journal Year: 2022, Volume and Issue: 146(5), P. 2142 - 2152

Published: Oct. 26, 2022

Brain changes have been reported in the first weeks after SARS-CoV-2 infection. However, limited literature exists about brain alterations post-COVID syndrome, a condition increasingly associated with cognitive impairment. The present study aimed to evaluate functional and structural patients assess whether these were related dysfunction. Eighty-six syndrome 36 healthy controls recruited underwent neuroimaging acquisition comprehensive neuropsychological assessment. Cognitive examinations performed 11 months symptoms of SARS-CoV-2. Whole-brain connectivity analysis was performed. Voxel-based morphometry grey matter volume, diffusion tensor imaging carried out analyse white-matter alterations. Correlations between cognition conducted Bonferroni corrected. Post-COVID presented changes, characterized by hypoconnectivity left right parahippocampal areas, bilateral orbitofrontal cerebellar areas compared controls. These accompanied reduced volume cortical, limbic white axial mean diffusivity. Grey loss showed significant associations more pronounced hospitalized non-hospitalized patients. No vaccination status found. shows persistent abnormalities acute are dysfunction contribute better understanding pathophysiology syndrome.

Language: Английский

Citations

145
Long-COVID post-viral chronic fatigue and affective symptoms are associated with oxidative damage, lowered antioxidant defenses and inflammation: a proof of concept and mechanism study DOI Open Access
Hussein Kadhem Al‐Hakeim, Haneen Tahseen Al-Rubaye,

Dhurgham Shihab Al-Hadrawi

et al.

Molecular Psychiatry, Journal Year: 2022, Volume and Issue: 28(2), P. 564 - 578

Published: Oct. 24, 2022

Language: Английский

Citations

142