Emerging Bioprinting for Wound Healing

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 11, 2023

Bioprinting has attracted much attention due to its suitability for fabricating biomedical devices. In particular, bioprinting become one of the growing centers in field wound healing, with various types bioprinted devices being developed, including 3D scaffolds, microneedle patches, and flexible electronics. Bioprinted can be designed specific biostructures biofunctions that closely match shape sites accelerate regeneration skin through approaches. Herein, a comprehensive review smart dressings is presented, emphasizing crucial effect determining biofunctions. The begins an overview techniques devices, followed in-depth discussion polymer-based inks, modification strategies, additive ingredients, properties, applications. strategies are divided into seven categories, chemical synthesis novel physical blending, coaxial bioprinting, multimaterial absorption, immobilization, hybridization living cells, examples presented. Thereafter, frontiers 4D artificial intelligence-assisted situ discussed from perspective interdisciplinary sciences. Finally, current challenges future prospects this highlighted.

Language: Английский

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3D Printing as a Technological Strategy for the Personalized Treatment of Wound Healing

AAPS PharmSciTech, Journal Year: 2023, Volume and Issue: 24(1)

Published: Jan. 25, 2023

Language: Английский

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Exploring Skin Wound Healing Models and the Impact of Natural Lipids on the Healing Process

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3790 - 3790

Published: March 28, 2024

Cutaneous wound healing is a complex biological process involving series of well-coordinated events aimed at restoring skin integrity and function. Various experimental models have been developed to study the mechanisms underlying repair evaluate potential therapeutic interventions. This review explores diverse array utilized in research, ranging from rodent excisional wounds advanced tissue engineering constructs microfluidic platforms. More importantly, influence lipids on examined, emphasizing their role enhancing barrier function restoration, modulating inflammation, promoting cell proliferation, remodeling. Lipids, such as phospholipids, sphingolipids, ceramides, play crucial roles membrane structure, signaling, repair. Understanding interplay between microenvironment provides valuable insights into development novel strategies for efficient regeneration. highlights significance investigating elucidating intricate involvement process, offering avenues improving clinical outcomes management.

Language: Английский

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Nanomaterials in the Wound Healing Process: New Insights and Advancements

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(3), P. 300 - 300

Published: Feb. 21, 2024

Wounds, which are becoming more common as a result of traumas, surgery, burns, and chronic illnesses like diabetes, remain critical medical problem. Infectious bacteria impact the healing process, particularly if its biofilm (biological films) leads to prolonged effect. Nanomaterials have emerged promising candidates in field wound due their unique properties versatile applications. New insights into interactions between nanomaterials microenvironments shed light on mechanisms underlying therapeutic effects. However, significantly minimal amount research has been carried out see these promote process. In this review, we provided an outline various types that studied for wounds infection prevention. Overall, utilization holds great promise continues evolve, providing new opportunities development effective efficient care therapies.

Language: Английский

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Hydrogel-mediated extracellular vesicles for enhanced wound healing: the latest progress, and their prospects for 3D bioprinting

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 10, 2024

Abstract Extracellular vesicles have shown promising tissue recovery-promoting effects, making them increasingly sought-after for their therapeutic potential in wound treatment. However, traditional extracellular vesicle applications suffer from limitations such as rapid degradation and short maintenance during administration. To address these challenges, a growing body of research highlights the role hydrogels effective carriers sustained release, thereby facilitating healing. The combination with development 3D bioprinting create composite hydrogel systems boasting excellent mechanical properties biological activity, presenting novel approach to healing skin dressing. This comprehensive review explores remarkable hydrogels, specifically suited loading vesicles. We delve into diverse sources analyzing integration within formulations Different methods well bioprinting, adapted varying conditions construction strategies, are examined roles promoting results highlight vesicle-laden advanced tools field treatment, offering both support bioactive functions. By providing an in-depth examination various that can play healing, this sheds light on directions further development. Finally, we challenges associated application along emerging trends domain. discussion covers issues scalability, regulatory considerations, translation technology practical clinical settings. In conclusion, underlines significant contributions hydrogel-mediated therapy regeneration. It serves valuable resource researchers practitioners alike, fostering deeper understanding benefits, applications, involved utilizing Graphical abstract

Language: Английский

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3D Bioprinting Using Hydrogels: Cell Inks and Tissue Engineering Applications

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(12), P. 2596 - 2596

Published: Nov. 24, 2022

3D bioprinting is transforming tissue engineering in medicine by providing novel methods that are precise and highly customizable to create biological tissues. The selection of a “cell ink”, printable formulation, an integral part adapting processes allow for process optimization customization related the target tissue. Bioprinting hydrogels allows tailorable material, physical, chemical, properties cell ink suited biomedical applications. Hydrogel-based formulations promising option variety techniques with which can be achieved. In this review, we will examine some current hydrogel-based inks used bioprinting, as well their use proposed future methods. We highlight applications discuss development new incorporate completed print into or organ interest.

Language: Английский

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Robust Alcohol Soluble Polyurethane/Chitosan/Silk Sericin (APU/CS/SS) Nanofiber Scaffolds Toward Artificial Skin Extracellular Matrices via Microfluidic Blow-Spinning

Advanced Fiber Materials, Journal Year: 2022, Volume and Issue: 5(1), P. 349 - 361

Published: Nov. 3, 2022

Language: Английский

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4D Printing: The Development of Responsive Materials Using 3D-Printing Technology

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(12), P. 2743 - 2743

Published: Dec. 7, 2023

Additive manufacturing, widely known as 3D printing, has revolutionized the production of biomaterials. While conventional 3D-printed structures are perceived static, 4D printing introduces ability to fabricate materials capable self-transforming their configuration or function over time in response external stimuli such temperature, light, electric field. This transformative technology garnered significant attention field biomedical engineering due its potential address limitations associated with traditional therapies. Here, we delve into an in-depth review 4D-printing systems, exploring diverse applications and meticulously evaluating advantages disadvantages. We emphasize novelty this paper by highlighting latest advancements emerging trends technology, particularly context applications.

Language: Английский

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Application of 3D- printed hydrogels in wound healing and regenerative medicine

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 167, P. 115416 - 115416

Published: Sept. 6, 2023

Hydrogels are three-dimensional polymer networks with hydrophilic properties. The modifiable properties of hydrogels and the structure resembling living tissue allow their versatile application. Therefore, increasing attention is focused on use as bioinks for (3D) printing in engineering. Bioprinting involves fabrication complex structures from several types materials, cells, bioactive compounds. Stem cells (SC), such mesenchymal stromal (MSCs) frequently employed 3D constructs. SCs have desirable biological ability to differentiate into various high proliferative capacity. Encapsulating hydrogel constructs enhances reparative abilities improves likelihood reaching target tissues. In addition, created can simulate environment mimic signals. Importantly, immunogenicity scaffolds minimized through patient-specific biocompatibility biodegradability biopolymers. Regenerative medicine taking advantage aforementioned capabilities regenerating tissues- muscle, bones, nerves, heart, skin, cartilage.

Language: Английский

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Application of Hydrogels as Three-Dimensional Bioprinting Ink for Tissue Engineering

Gels, Journal Year: 2023, Volume and Issue: 9(2), P. 88 - 88

Published: Jan. 19, 2023

The use of three-dimensional bioprinting technology combined with the principle tissue engineering is important for construction or organ regeneration microenvironments. As a ink, hydrogels need to be highly printable and provide stiff cell-friendly microenvironment. At present, are used as inks in engineering. However, there still lack summary latest 3D printing properties hydrogel materials. In this paper, materials commonly bioinks; advanced technologies including inkjet bioprinting, extrusion laser-assisted stereolithography suspension digital technologies; characterization printability fidelity; biological properties, application fields bone engineering, skin cardiovascular reviewed, current problems future directions prospected.

Language: Английский

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