Chitosan-Based Hemostatic Hydrogels: The Concept, Mechanism, Application, and Prospects

Molecules, Journal Year: 2023, Volume and Issue: 28(3), P. 1473 - 1473

Published: Feb. 3, 2023

The design of new hemostatic materials to mitigate uncontrolled bleeding in emergencies is challenging. Chitosan-based hydrogels have frequently been used for hemostasis due their unique biocompatibility, tunable mechanical properties, injectability, and ease handling. Moreover, chitosan (CS) absorbs red blood cells activates platelets promote hemostasis. Benefiting from these desired the application CS attracting ever-increasing research attention. This paper reviews recent progress CS-based advantageous characteristics compared traditional materials. effects mechanism, deacetylation degree, relative molecular mass, chemical modification on performance are summarized. Meanwhile, some typical applications introduced provide references preparation efficient hydrogels. Finally, future perspectives presented.

Language: Английский

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Bioadhesive Technology Platforms

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(24), P. 14084 - 14118

Published: Nov. 16, 2023

Bioadhesives have emerged as transformative and versatile tools in healthcare, offering the ability to attach tissues with ease minimal damage. These materials present numerous opportunities for tissue repair biomedical device integration, creating a broad landscape of applications that captivated clinical scientific interest alike. However, fully unlocking their potential requires multifaceted design strategies involving optimal adhesion, suitable biological interactions, efficient signal communication. In this Review, we delve into these pivotal aspects bioadhesive design, highlight latest advances applications, identify lie ahead bioadhesives multifunctional technology platforms.

Language: Английский

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Gelable and Adhesive Powder for Lethal Non‐Compressible Hemorrhage Control

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(46)

Published: Aug. 4, 2023

Abstract Hemostatic powders are widely used in clinical and emergency situations but often exhibit low wet adhesion, cytotoxicity concerns, do not work well for lethal non‐compressible hemorrhage. Here a new kind of gelable adhesive powder (GAP) is developed, which integrates chitosan microspheres (CM), tetra‐armed poly(ethylene glycol) amine (Tetra‐PEG‐NH 2 ), succinimidyl succinate (Tetra‐PEG‐SS). Upon application to the wound site, macroporous CM can rapidly absorb interfacial liquids, meanwhile, hydrated GAP turns into hydrogel (crosslinking between Tetra‐PEG‐SS CM/Tetra‐PEG‐NH ) with stable robust adhesion tissue though covalent bonding. The vitro vivo results suggest that optimized formulation exhibits strong adhesive, high burst pressure, enhanced blood clotting ability, as excellent biocompatibility on‐demand removal properties. A significantly improved hemostatic efficacy demonstrated rat liver, spleen, femoral artery injury models compared CM, commercial fibrin glue, Yunnan Baiyao (YB). also halt severe bleeding from pig visceral organs. Overall, proposed has many advantages including good biocompatibility, rapid effective hemostasis, cost, ease use, making it promising hemostat hemorrhage control.

Language: Английский

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Flexible Bioactive Glass Nanofiber-Based Self-Expanding Cryogels with Superelasticity and Bioadhesion Enabling Hemostasis and Wound Healing

ACS Nano, Journal Year: 2023, Volume and Issue: 17(12), P. 11507 - 11520

Published: June 6, 2023

Self-expanding cryogels hold unique prospects for treating uncontrollable hemorrhages. However, development of a mechanically robust, tissue-adhesive, and bioactive self-expanding cryogel enabling effective hemostasis tissue repair has remained great challenge. Herein, we report superelastic cellular-structured glass nanofibrous (BGNC) composed highly flexible BG nanofibers citric acid-cross-linked poly(vinyl alcohol). These BGNCs exhibit high absorption capacity (3169%), fast ability, near zero Poisson's ratio, injectability, compressive recovery at strain 80%, robust fatigue resistance (almost no plastic deformation after 800 cycles 60%), good adhesion with diverse tissues. The provide sustained release Ca, Si, P ions. Moreover, the present better blood clotting cell ability superior hemostatic in rabbit liver femoral artery hemorrhage models as compared commercial gelatin sponges. In addition, are able to stop bleeding rat cardiac puncture injury about 1 min. Furthermore, capable promoting full-thickness skin wound healing. superelasticity bioadhesion provides promising strategy exploring multifunctional materials.

Language: Английский

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Mimosa‐Inspired Stimuli‐Responsive Curling Bioadhesive Tape Promotes Peripheral Nerve Regeneration

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(32)

Published: May 19, 2023

Abstract Trauma often results in peripheral nerve injuries (PNIs). These are particularly challenging therapeutically because of variable diameters, slow axonal regeneration, infection severed ends, fragility the tissue, and intricacy surgical intervention. Surgical suturing is likely to cause additional damage nerves. Therefore, an ideal scaffold should possess good biocompatibility, diameter adaptability, a stable biological interface for seamless biointegration with tissues. Inspired by curl Mimosa pudica , this study aimed design develop diameter‐adaptable, suture‐free, stimulated curling bioadhesive tape (SCT) hydrogel repairing PNI. The fabricated from chitosan acrylic acid‐N‐hydroxysuccinimide lipid via gradient crosslinking using glutaraldehyde. It closely matches nerves different individuals regions, thereby providing bionic regeneration. In addition, rapidly absorbs tissue fluid surface achieving durable wet‐interface adhesion. Furthermore, chitosan‐based SCT loaded insulin‐like growth factor‐I effectively promotes regeneration excellent bioactivity. This procedure injury repair simple reduces difficulty duration surgery, advancing adaptive biointerfaces reliable materials repair.

Language: Английский

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An Injectable Hydrogel with Ultrahigh Burst Pressure and Innate Antibacterial Activity for Emergency Hemostasis and Wound Repair

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(33)

Published: June 14, 2024

Abstract Uncontrolled bleeding and wound infections following severe trauma pose significant challenges for existing tissue adhesives, primarily due to their weak wet adhesion, slow adhesion formation, cytotoxicity concerns, lack of antibacterial properties. Herein, an injectable hydrogel (denoted as ES gel) with rapid, robust adhesive sealing inherent activity based on ε‐polylysine a poly(ethylene glycol) derivative is developed. The engineered exhibits rapid gelation behavior, high mechanical strength, strong various tissues, can sustain ultrahigh burst pressure 450 mmHg. It also presents excellent biocompatibility, biodegradability, properties, on‐demand removability. Significantly improved hemostatic efficacy gel compared fibrin glue demonstrated using injury models in rats rabbits. Remarkably, the effectively halt lethal non‐compressible hemorrhages visceral organs (liver, spleen, heart) femoral artery fully anticoagulated pigs. Furthermore, outperforms commercial products sutureless closure repair rat liver defect, skin incision, infected full‐thickness models. Overall, this study highlights promising clinical applications managing uncontrolled hemorrhage, closure, repair.

Language: Английский

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A 3D printable tissue adhesive

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 9, 2024

Abstract Tissue adhesives are promising alternatives to sutures and staples for joining tissues, sealing defects, immobilizing devices. However, existing mostly take the forms of glues or hydrogels, which offer limited versatility. We report a direct-ink-write 3D printable tissue adhesive can be used fabricate bioadhesive patches devices with programmable architectures, unlocking new potential application-specific designs. The is conformable stretchable, achieves robust adhesion wet tissues within seconds, exhibits favorable biocompatibility. In vivo rat trachea colon defect models demonstrate fluid-tight capability printed patches, maintained over 4 weeks. Moreover, incorporation blood-repelling hydrophobic matrix enables seal actively bleeding tissues. Beyond wound closure, has broad applicability across various tissue-interfacing devices, highlighted through representative proof-of-concept Together, this platform offers strategy toward developing advanced technologies.

Language: Английский

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Bioinspired Microstructured Janus Bioadhesive for the Prevention of Abdominal and Intrauterine Adhesions

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(21)

Published: Jan. 28, 2024

Abstract Abdominal and intrauterine adhesions are common postoperative problems that can cause serious complications. Current adhesives usually double sided suffer from poor wet adhesion, nondegradability, monofunctionality, which limits their application in preventing adhesions. Herein, a bioinspired microstructured Janus bioadhesive, named OD/GM@PG, with adhesive inner layer an antiadhesive outer is prepared by combining electrostatic spun materials. By using both capillary suction catechol‐based strategy, the strength interfacial toughness of bioadhesive reach 98 kPa 325 J m −2 , respectively, much higher than those commercial fibrin glues cyanoacrylate glues. The acts as physical barrier friction‐reducing effects. Additionally, demonstrates biodegradable, hemostatic, antioxidative, anti‐inflammatory, prohealing properties. In vivo results show asymmetric adhesion effect effectively abdominal Notably, tandem mass tags‐labeled quantitative proteomics analysis demonstrate expression inflammatory response‐associated proteins (S100A8, S100A9) associated adhesion; significantly downregulates this expression. Therefore, OD/GM@PG promising candidate for

Language: Английский

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Superporous sponge prepared by secondary network compaction with enhanced permeability and mechanical properties for non-compressible hemostasis in pigs

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 27, 2024

Abstract Developing superporous hemostatic sponges with simultaneously enhanced permeability and mechanical properties remains challenging but highly desirable to achieve rapid hemostasis for non-compressible hemorrhage. Typical approaches improve the of by increasing porosity sacrifice yield limited pore interconnectivity, thereby undermining efficacy subsequent tissue regeneration. Herein, we propose a temperature-assisted secondary network compaction strategy following phase separation-induced primary fabricate chitosan sponge highly-interconnected porous structure, blood absorption rate capacity, fatigue resistance. The exhibits shape recovery after absorbing maintains sufficient pressure on wounds build robust physical barrier greatly efficiency. Furthermore, outperforms commercial gauze, gelatin sponges, powder enhancing efficiency, cell infiltration, vascular regeneration, in-situ regeneration in organ injury models, respectively. We believe proposed provides simple yet effective method diverse clinical applications.

Language: Английский

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Anisotropic Shape‐Memory Cryogel with Oriented Macroporous Channel for Hemorrhage Control and Tissue Generation

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Abstract Injectable shape‐memory materials represent a promising solution for managing severe bleeding from deep, inaccessible wounds. However, many existing expandable hemostats consist of randomly porous networks and often exhibit inadequate liquid absorption, non‐degradability, potential cytotoxicity, which limits their effectiveness in hemostasis wound repair. To overcome these challenges, this study introduces an anisotropic hemostatic cryogel, SALC, featuring oriented macroporous channels made biocompatible polymers (poly(ethylene glycol), gelatin, lignin) through simple one‐step cryo‐structuration process. This structural alignment provides the cryogel with low water flow resistance, efficient fluid transport, rapid shape recovery. SALC demonstrates superior adsorption retention, vitro tamponade sealing, pro‐coagulant properties compared to commercial gelatin sponges XSTAT, along favorable biocompatibility biodegradability. The efficacy surpasses clinically used counterparts rat models liver perforation femoral artery transection. Remarkably, achieves effective porcine hepatic, artery, cardiac injuries. Additionally, supports tissue regeneration by promoting cell migration angiogenesis while mitigating inflammatory responses. is also lightweight easy carry implement. Overall, shows clinical applications treating hemorrhages improving healing.

Language: Английский

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