Nutrition Journal, Journal Year: 2024, Volume and Issue: 23(1)
Published: Nov. 9, 2024
Less is known whether the amino acid composition of dietary protein sources effects on long-term health outcomes. We aimed to evaluate association between and all-cause cause-specific mortality.
Language: Английский
Cell Insight, Journal Year: 2025, Volume and Issue: unknown, P. 100227 - 100227
Published: Jan. 1, 2025
The human gut microbiota plays a critical role in maintaining host homeostasis through metabolic activities. Among these, amino acid (AA) metabolism by the large intestine is highly heterogeneous and relevant to health. Despite increasing interest, microbial AA remains relatively unexplored. This review highlights recent advances colonic metabolism, including auxotrophies, synthesis, dissimilatory metabolites, their implications health, focusing on major gastrointestinal diseases colorectal cancer, inflammatory bowel disease, irritable syndrome.
Language: Английский
Citations
1
Biotechnology Advances, Journal Year: 2024, Volume and Issue: 71, P. 108305 - 108305
Published: Jan. 11, 2024
Language: Английский
Citations
6
Cell Proliferation, Journal Year: 2023, Volume and Issue: 56(12)
Published: May 4, 2023
Acute liver injury (ALI) is a severe disease that characterized by sudden and massive hepatocyte necrosis deterioration of functions. Oxidative stress increasingly recognized as key factor in the induction progression ALI. Scavenging excessive reactive oxygen species (ROS) with antioxidants has become promising therapeutic option, but intrinsically hepatocyte-targeting excellent bioavailability biocompatibility are yet to be developed. Herein, self-assembling nanoparticles (NPs) composed amphiphilic polymers introduced encapsulate organic Selenium compound L-Se-methylselenocysteine (SeMC) form SeMC NPs, which protect viabilities functions cultured hepatocytes drug- or chemical-induced acute hepatotoxicity models via efficient ROS removal. After further functionalization ligand glycyrrhetinic acid (GA), resultant GA-SeMC NPs exhibit enhanced uptake accumulation. In mouse ALI induced acetaminophen (APAP) carbon tetrachloride (CCl4 ), treatment significantly decrease levels hepatic lipid peroxidation, tissue vacuolization serum transaminases, while prominently increase endogenous antioxidant enzymes. Our study therefore presents liver-targeting drug delivery strategy for prevention diseases.
Language: Английский
Citations
16
Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11
Published: April 11, 2024
Across species, taste provides important chemical information about potential food sources and the surrounding environment. As details chemicals receptors responsible for gustation are discovered, a complex view of system is emerging with significant contributions from research using fruit fly, Drosophila melanogaster , as model organism. In this brief review, we summarize recent advances in their relevance to more broadly. Our goal highlight molecular mechanisms underlying first step gustatory circuits: ligand-receptor interactions primary cells. After an introduction how it encodes canonical modalities sweet, bitter, salty, describe insights into nature carboxylic acid amino detection context sour umami taste, respectively. analysis extends non-canonical including metals, fatty acids, bacterial components, highlights unexpected signaling pathways that have recently been identified Comparing intricate cellular underpinnings ligands detected vivo flies reveals both specific promiscuous receptor selectivity encoding. Throughout compare contextualize these findings mammalian not only emphasize conservation chemosensory systems, but demonstrate power organism elucidating neurobiology feeding.
Language: Английский
Citations
5
Metabolites, Journal Year: 2024, Volume and Issue: 14(7), P. 370 - 370
Published: June 30, 2024
Amino acids (AAs) and their metabolites are important building blocks, energy sources, signaling molecules associated with various pathological phenotypes. The quantification of AA tryptophan (TRP) in human serum plasma is therefore great diagnostic interest. Therefore, robust, reproducible sample extraction processing workflows as well rapid, sensitive absolute required to identify candidate biomarkers improve screening methods. We developed a validated semi-automated robotic liquid workflow rapid method for 20 free, underivatized AAs six TRP using dual-column U(H)PLC-MRM-MS. preparation 96-well plate was optimized high throughput allowing transfer samples the U(H)PLC autosampler directly without additional cleanup steps. U(H)PLC-MRM-MS method, mixed-mode reversed-phase anion exchange column formic acid high-strength silica difluoro-acetic mobile phase additive, provided nanomolar lower limits within 7.9 min. applied prostate cancer study shown discriminate between treatment regimens responsible discriminating healthy controls patients on active surveillance.
Language: Английский
Citations
4
Annals of Animal Science, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 26, 2025
Abstract This study explored the impact of whole grain oat, barley, wheat, and corn used in final stage fattening (14-16 week age) on properties meat liver White Kołuda ® geese, variations between examined tissues. Two identical experiments were conducted to enhance credibility results. Goose livers showed significantly higher protein content than leg muscles with oats increased breasts livers. Each method resulted sum essential amino acids ( EAA) exceeding WHO standard. Barley oat-based yielded most favourable results terms quality, often resulting acid index (EAAI) values (161-179) compared other two groups (159-166). The goose boasted elevated levels elements demonstrated significant richness both iron (Fe) (337 mg/kg) copper (Cu) (304 mg/kg), substantially surpassing daily requirements a 100 g serving. products from oatfed barley-fed also exhibited several elements, while corn-based typically displayed some lowest elements. breast darker colour redder hue less yellowness legs. Additionally, darkest shade when fattened yellowest oats.
Language: Английский
Citations
0
Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 939 - 939
Published: March 7, 2025
Meat is a major source of dietary protein and fat across the globe. Red white meat are terms consumers use to refer types meat; however, these do not fully encompass range nutrients provided by sources. refers from mammalian skeletal muscle, while poultry. both provide wide nutritional components in context fatty acids, amino acids micronutrients. Importantly, it has been demonstrated that acid profiles differ between red as well different sources meat. complete meaning contains all essential (EAAs), addition, non-essential (NEAAs). also most abundant bioavailable heme-iron for muscle growth cardiovascular health. indicated contributor rising incidence metabolic disorders even colorectal cancer. However, important note consumption linked conditions, typically overconsumption associated with obesity other symptoms. Similarly, preparation key factor its link cancer some methods produce carcinogens others not. Finally, may be situationally more beneficial groups than others, particularly cases sex aging. For pregnant women, increases increase intake semi-essential elderly, better preserve mass compared
Language: Английский
Citations
0
Current Research in Food Science, Journal Year: 2025, Volume and Issue: 10, P. 101022 - 101022
Published: Jan. 1, 2025
Plant-based meat analogs (PBMAs) have attracted attention owing to their various advantages, however, taste limits application, requiring improvement of the umami and saltiness levels while meeting clean-label requirements. Enzymatic treatments for food processing are effective strategies developing products because enzymes not considered additives. In this study, we aimed enhance intensity PBMA patties by combining protease- glutaminase-catalyzed reactions. For production extrudates construct patties, enzymatically hydrolyzed pea proteins (eHPP) were produced via enzyme catalysis combinations, followed preparation eHPP-mixed textured protein (eTPP) from eHPP starch. Sensory evaluation revealed that umami, kokumi, eTPP-based containing 0.5% NaCl significantly higher than those control NaCl. Notably, exhibited a 20% salt reduction. By screening saltiness-enhancing amino acids peptides released in artificial saliva, combination Glu, Arg, Lys, separated peptide 3 was determined important enhancing Moreover, it may be Maillard-induced peptide, based on Lys residues Glu-Gly-Lys-Gly 5-hydroxymethylfurfural condensed Glucose starch during extrusion process. Our findings suggest proteases glutaminases could an attractive approach
Language: Английский
Citations
0
Food and Humanity, Journal Year: 2025, Volume and Issue: unknown, P. 100564 - 100564
Published: March 1, 2025
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: April 19, 2025
Abstract Restricting dietary protein intake has metabolic and physiological benefits for animals. Rodent studies have identified the involvement of a hormone fibroblast growth factor 21 (FGF21), which is upregulated by sensing amino acid scarcity. However, to what extent this mechanism conserved in primates remains elusive. Using common marmosets Callithrix jacchus as non-human primate model, we demonstrate protocol restriction manipulation. Low diet induces decrease blood urea nitrogen, altered plasma profiles, an increase FGF21. Supplementation purified acids suppresses features restriction. Our data provide intervention technique insight into evolutionarily FGF21 induction during
Language: Английский
Citations
0