Current Opinion in Biotechnology, Journal Year: 2023, Volume and Issue: 82, P. 102966 - 102966
Published: June 28, 2023
Language: Английский
European Polymer Journal, Journal Year: 2024, Volume and Issue: 206, P. 112803 - 112803
Published: Jan. 26, 2024
Language: Английский
Citations
17
Smart Materials in Medicine, Journal Year: 2024, Volume and Issue: 5(2), P. 183 - 195
Published: Jan. 12, 2024
Since the need for vascular networks to supply oxygen and nutrients while expelling metabolic waste, most cells can only survive within 200 μm of blood vessels; thus, construction well-developed vessel is essential manufacture artificial tissues organs. Three-dimensional (denoted as 3D) printing a scalable, reproducible high-precision manufacturing technology. In past several years, there have been many breakthroughs in building various vascularized tissues, greatly promoting development biological tissue engineering. This paper highlights latest progress 3D printed organs, including heart, liver, lung, kidney, penis. We also discuss application status potential above prospect further requirement technology clinically useable tissues.
Language: Английский
Citations
15
Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: 2(6), P. 486 - 500
Published: April 2, 2024
Language: Английский
Citations
14
Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)
Published: June 17, 2024
Abstract Microgels prepared from natural or synthetic hydrogel materials have aroused extensive attention as multifunctional cells drug carriers, that are promising for tissue engineering and regenerative medicine. can also be aggregated into microporous scaffolds, promoting cell infiltration proliferation repair. This review gives an overview of recent developments in the fabrication techniques applications microgels. A series conventional novel strategies including emulsification, microfluidic, lithography, electrospray, centrifugation, gas-shearing, three-dimensional bioprinting, etc. discussed depth. The characteristics microgels microgel-based scaffolds culture delivery elaborated with emphasis on advantages these carriers therapy. Additionally, we expound ongoing foreseeable current limitations their aggregate field biomedical engineering. Through stimulating innovative ideas, present paves new avenues expanding application techniques.
Language: Английский
Citations
12
Carbon, Journal Year: 2024, Volume and Issue: 226, P. 119196 - 119196
Published: April 28, 2024
The challenge of creating flexible and sustainable electronics with properties such as lightweight, electrical thermal conductivity, electromagnetic interference (EMI) shielding is addressed in this study. Carbon nanotubes graphene are commonly used electronic devices, but gaps exist their conductivity flexibility. A novel scalable fabrication method introduced, involving the creation bio-based nanocomposites by integrating high aspect-ratio nanoribbons (GNRs) into a poly(lactic acid) (PLA) matrix. were drawn above glass transition temperature (Tg) PLA, resulting formation extended shish structures, observed scanning electron microscope (SEM) images. These structures significantly enhanced conductivities, well EMI features. combination GNR nanofillers uniaxial stretching led to substantial increase Young's modulus, tensile strength, toughness approximately 550%, 440%, 600%, respectively, most likely due increased network connection despite higher flexibility GNRs. Moreover, in-plane registered notable enhancement 110%. reached 26 dB, an absorption contribution around 45%. Additional improvement was achieved through foaming stretched samples, multilayer alternative foam structures. Furthermore, significant augmentation 33 dB total foamed accompanied 85% SEA documented. promising findings underscore potential applications across diverse domains, including interface materials, packaging, capacitors, energy storage specific emphasis on realm stretchable electronics.
Language: Английский
Citations
10
Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 273 - 293
Published: Feb. 20, 2025
Language: Английский
Citations
1
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown
Published: May 15, 2024
Granular hydrogels composed of hydrogel microparticles are promising candidates for 3D bioprinting due to their ability protect encapsulated cells. However, achieve high print fidelity, need jam exhibit shear-thinning characteristics, which is crucial printing. Unfortunately, this overpacking can significantly impact cell viability, thereby negating the primary advantage using shield cells from shear forces. To overcome challenge, a novel solution: biphasic, granular colloidal bioink designed optimize viability and printing fidelity introduced. The biphasic ink consists cell-laden polyethylene glycol (PEG) embedded in continuous gelatin methacryloyl (GelMA)-nanosilicate network. Here, it demonstrated that offers outstanding rheological properties, structural stability. Furthermore, its utility engineering complex tissues with multiple types heterogeneous microenvironments demonstrated, by incorporating β-islet into PEG endothelial GelMA-nanosilicate Using approach, possible induce patterning, enhance vascularization, direct cellular function. proposed holds significant potential numerous emerging biomedical applications, including tissue disease modeling.
Language: Английский
Citations
5
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: 17(6), P. 8771 - 8793
Published: Jan. 30, 2025
Cultured meat aims to produce mass by culturing cells and tissues based on the muscle regeneration mechanism, is considered an alternative raising slaughtering livestock. Hydrogel building blocks are commonly used as substrates for cell culture in tissue engineering cultured because of their high water content, biocompatibility, similar three-dimensional (3D) environment cellular niche vivo. With characteristics precise manipulation fluids, microfluidics exhibits advantages fabrication with different structures components, which have been widely applied regeneration. Microfluidic show promising prospects field meat; however, few reviews application microfluidic published. This review outlines recent status use meat. Starting introduction materials construction, we then describe diverse fabricated blocks, including microspheres, microfibers, microsphere-microfiber hybrid systems. Next, stacking strategies construction highlighted detail. Finally, challenges future developing discussed.
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 2, 2025
Abstract Microgels offer unique advantages over bulk hydrogels due to their improved diffusion limits for oxygen and nutrients. Particularly, stimuli-responsive microgels with inherently bioactive self-supporting properties emerge as highly promising biomaterials. This study unveils the development of interparticle-crosslinked, self-supporting, ion-responsive tailored 3D 4D (bio)printing applications. A novel strategy was proposed develop that enabled interparticle crosslinking, eliminating need filler preserving essential microscale void spaces support cell migration vascularization. Additionally, these possessed unique, shrinking behavior primarily by Hofmeister effect, reversible upon removal stimulus. Two types microgels, spherical (µS) random-shaped (µR), were fabricated, µR exhibiting superior mechanical higher packing density. Fabricated microgel-based constructs supported angiogenesis tunable vessel size based on interstitial while demonstrating excellent shear-thinning self-healing high print fidelity. Various bioprinting techniques employed validated using including extrusion-based, embedded, intraembedded, aspiration-assisted bioprinting, facilitating biofabrication scalable constructs. Multi-material printing achieved combining non-responsive enabling programmable shape transformations exposure ionic solutions. Utilizing printing, complex, dynamic structures generated such coiling filaments, grippers, folding sheets, providing a foundation advanced tissue models devices regenerative medicine soft robotics, respectively.
Language: Английский
Citations
0
ACS Sustainable Chemistry & Engineering, Journal Year: 2023, Volume and Issue: 11(46), P. 16365 - 16406
Published: Nov. 8, 2023
Light-induced cross-linking of liquid monomers has found widespread applications in various fields, such as dentistry, coatings, tissue engineering, and 3D printing. These processes typically rely on derived from petrochemicals, which are volatile price becoming increasingly depleted, compelling researchers to explore alternative sources forestry agricultural crops. The renewability these resources makes them a promising option for developing substitutive materials with similar or superior properties. structural subunits biomass offer building blocks petroleum-based photopolymers including the double bond-containing hydrophobic fatty acids terpenes, hydrophilic carbohydrates proteins, aromatic furfural compounds carbohydrates, phenolic moieties lignin. They can be transformed into by inherent chemically introduced photocurable bonds. This review seeks highlight recent advancements transforming renewable platform chemicals systems photopolymerization examines thermomechanical properties resulting cured materials. Furthermore, potential issues improvement also identified, cost-effectiveness biomass-based risk competition food production. perspectives future directions improving this area given.
Language: Английский
Citations
11