Matter, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(21)
Published: Feb. 3, 2024
Abstract Spinal cord injury (SCI) is a refractory neurological disorder. Due to the complex pathological processes, especially secondary inflammatory cascade and lack of intrinsic regenerative capacity, it difficult recover function after SCI. Meanwhile, simulating conductive microenvironment spinal reconstructs electrical neural signal transmission interrupted by SCI facilitates repair. Therefore, double‐crosslinked hydrogel (BP@Hydrogel) containing black phosphorus nanoplates (BP) synthesized. When placed in rotating magnetic field (RMF), BP@Hydrogel can generate stable signals exhibit electrogenic characteristic. In vitro, shows satisfactory biocompatibility alleviate activation microglia. RMF, enhances anti‐inflammatory effects. wireless stimulation promotes differentiation stem cells (NSCs) into neurons, which associated with PI3K/AKT pathway. vivo, injectable elicit behavioral electrophysiological recovery complete transected mice alleviating inflammation facilitating endogenous NSCs form functional neurons synapses under RMF. The present research develops multifunctional for repair targeting multiple mechanisms including immunoregulation enhancement neuronal differentiation.
Language: Английский
Citations
40
ACS Nano, Journal Year: 2024, Volume and Issue: 18(22), P. 14427 - 14440
Published: May 22, 2024
Muscle atrophy resulting from peripheral nerve injury (PNI) poses a threat to patient's mobility and sensitivity. However, an effective method inhibit muscle following PNI remains elusive. Drawing inspiration the sea cucumber, we have integrated microneedles (MNs) microchannel technology into guidance conduits (NGCs) develop bionic microneedle NGCs (MNGCs) that emulate structure piezoelectric function of cucumbers. Morphologically, MNGCs feature outer surface with outward-pointing needle tips capable applying electrical stimulation denervated muscles. Simultaneously, interior contains microchannels designed guide migration Schwann cells (SCs). Physiologically, incorporation conductive reduced graphene oxide zinc nanoparticles polycaprolactone scaffold enhances conductivity properties, facilitating SCs' migration, myelin regeneration, axon growth, restoration neuromuscular function. These combined effects ultimately lead inhibition Consequently, concept synergistic effect inhibiting promoting regeneration has capacity transform traditional approach repair find broad applications in repair.
Language: Английский
Citations
27
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(12), P. 5161 - 5180
Published: Aug. 23, 2024
Microneedles (MNs) serve as a revolutionary paradigm in transdermal drug delivery, heralding viable resolution to the formidable barriers presented by cutaneous interface. This review examines MNs an advanced approach enhancing dermatological pathology management. It explores complex dermis structure and highlights limitations of traditional methods, emphasizing MNs' advantage bypassing stratum corneum deliver drugs directly subdermal matrix. The discourse outlines diverse typologies MNs, including solid, coated, hollow, hydrogel, dissolvable versions. Each type is characterized its unique applications benefits. treatise details deployment alleviation cancers, administration inflammatory dermatoses such psoriasis atopic dermatitis, their utility wound Additionally, paper contemplates prospects within realm aesthetic dermatology burgeoning market traction cosmetic MN formulations. summarizes scientific commercial challenges clinical adoption therapeutics, dosage calibration, pharmacodynamics, biocompatibility, patient compliance, sterilization, mass production, regulatory oversight. emphasizes need for ongoing research, innovation, harmonization overcome these obstacles fully realize potential treating skin diseases improving welfare. presents comprehensive overview recent accomplishments, remaining challenges, future microneedle-facilitated therapy afflictions.
Language: Английский
Citations
25
Materials Horizons, Journal Year: 2024, Volume and Issue: 11(11), P. 2667 - 2684
Published: Jan. 1, 2024
Microneedles for skin regeneration are conventionally restricted by uncontrollable multi-drug release, limited types of drugs, and poor wound adhesion. Here, a novel core-shell microneedle patch is developed scarless repair, where the shell composed hydrophilic gelatin methacryloyl (GelMA) loaded with mangiferin, an anti-inflammatory small molecule, core hydrophobic poly (lactide-co-propylene glycol-co-lactide) dimethacrylates (PGLADMA) bioactive macromolecule human mesenchymal stromal cell (hMSC)-derived exosomes. This material choice provides several benefits: GelMA swelling interface tissue interlocking rapid release mangiferin at early healing stage anti-inflammation, whereas PGLADMA offers long-term encapsulation exosomes (30% in 3 weeks), promoting sustained angiogenesis anti-inflammation. Our results demonstrate that possesses properties can induce both vitro terms macrophage polarization tube formation umbilical vein endothelial cells (HUVECs), vivo re-epithelization, vessel formation. Importantly, we also observe reduced scar vivo. Altogether, degradation dynamics our hydrophilic/hydrophobic materials enable design differential prolonged regeneration, potential other therapies exosome release.
Language: Английский
Citations
19
Nano Today, Journal Year: 2023, Volume and Issue: 52, P. 102000 - 102000
Published: Sept. 23, 2023
Language: Английский
Citations
32
Advanced Science, Journal Year: 2023, Volume and Issue: 11(8)
Published: Oct. 30, 2023
Microneedles have emerged as a promising platform for transdermal drug delivery with prominent advantages, such enhanced permeability, mitigated pain, and improved patient adherence. While microneedles primarily been employed delivering small molecules, nucleic acids, peptides, proteins, recent researches demonstrated their prospect in combination cell therapy. Cell therapy involving administration or transplantation of living cells (e.g. T cells, stem pancreatic cells) has gained significant attention preclinical clinical applications various disease treatments. However, the effectiveness systemic may be restricted localized conditions like solid tumors skin disorders due to limited penetration accumulation into lesions. In this perspective, an overview advances microneedle-assisted immunotherapy, tissue regeneration, hormone modulation, respect mechanical property, loading capacity, well viability bioactivity loaded is provided. Potential challenges future perspectives microneedle-mediated are also discussed.
Language: Английский
Citations
31
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(35), P. 8577 - 8604
Published: Jan. 1, 2024
Biosensors integrated into closed-loop systems provide patient-specific adaptive therapies. These advanced devices have significant potential for managing chronic conditions by continuously adjusting therapeutic regimens based on physiological data.
Language: Английский
Citations
16
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: Oct. 17, 2024
As a transdermal drug delivery method, microneedles offer minimal invasiveness, painlessness, and precise in-situ treatment. However, current rely on passive diffusion, leading to uncontrollable penetration. To overcome this, we developed pneumatic microneedle patch that uses live Enterobacter aerogenes as microengines actively control delivery. These microbes generate gas, driving drugs into deeper tissues, with adjustable glucose concentration allowing over the process. Our results showed this microorganism-powered system increases depth by 200%, reaching up 1000 μm below skin. In psoriasis animal model, technology effectively delivered calcitriol subcutaneous offering rapid symptom relief. This innovation addresses limitations of conventional microneedles, enhancing efficiency, permeability, introducing creative paradigm for on-demand controlled
Language: Английский
Citations
15
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 367, P. 184 - 196
Published: Jan. 26, 2024
Language: Английский
Citations
14
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 29, 2024
Abstract Glioblastoma multiforme (GBM) remains incurable despite multimodal treatments after surgical debulking. Almost all patients with GBM relapse within a narrow margin (2–3 cm) of the initial resected lesion due to unreachable residual cancerous cells. Here, completely biodegradable microneedle for cavity delivery glioblastoma‐associated macrophages (GAMs)‐activating immune nano‐stimulator that mitigates glioblastoma is reported. The tumor lesion‐directed biocompatible releases and toll‐like receptor 9 agonist in controlled manner until microneedles degrade over 1 week, efferently induce situ phonotypic shifting GAMs from anti‐ pro‐inflammatory recurrence obviously inhibited. implantable offer significant improvement conventional transdermal ones, as they are 100% degradable, ensuring safe application cavities. It also revealed T cells recruited niche initiate anti‐tumor response eradicate Taken together, this work provides potential strategy immunomodulating postoperative mitigate patients, which may have broad applications other malignancies intervention.
Language: Английский
Citations
14