Nanomaterials,
Journal Year:
2022,
Volume and Issue:
12(7), P. 1140 - 1140
Published: March 29, 2022
Inspired
by
observations
that
the
natural
topography
observed
on
cicada
and
dragonfly
wings
may
be
lethal
to
bacteria,
researchers
have
sought
reproduce
these
nanostructures
biomaterials
with
goal
of
reducing
implant-associated
infections.
Titanium
its
alloys
are
widely
employed
excellent
properties
but
susceptible
bacterial
colonisation.
Hydrothermal
etching
is
a
simple,
cost-effective
procedure
which
fabricates
nanoscale
protrusions
various
dimensions
upon
titanium,
depending
parameters
used.
We
investigated
role
time
choice
cation
(sodium
potassium)
in
alkaline
heat
treatment
topographical,
physical,
bactericidal
resulting
modified
titanium
surfaces.
Optimal
times
were
4
h
for
sodium
hydroxide
(NaOH)
5
potassium
(KOH).
NaOH
produced
dense,
somewhat
ordered,
surface
nanofeatures
75
nanospikes
per
µm2.
In
comparison,
KOH
resulted
sparser
nonetheless
disordered
morphology
only
8
spikes
The
was
more
effective
at
eliminating
Gram-negative
pathogens,
while
against
Gram-positive
strains.
These
findings
guide
further
research
development
surfaces
optimised
predominant
pathogens
associated
intended
application.
Antibiotics,
Journal Year:
2022,
Volume and Issue:
11(2), P. 200 - 200
Published: Feb. 4, 2022
Antibiotic
resistance,
and,
in
a
broader
perspective,
antimicrobial
resistance
(AMR),
continues
to
evolve
and
spread
beyond
all
boundaries.
As
result,
infectious
diseases
have
become
more
challenging
or
even
impossible
treat,
leading
an
increase
morbidity
mortality.
Despite
the
failure
of
conventional,
traditional
therapy,
past
two
decades,
no
novel
class
antibiotics
has
been
introduced.
Consequently,
several
alternative
strategies
combat
these
(multi-)
drug-resistant
microorganisms
identified.
The
purpose
this
review
is
gather
consider
that
are
being
applied
proposed
as
potential
alternatives
antibiotics.
These
include
combination
techniques
target
enzymes
proteins
responsible
for
resistant
bacteria,
drug
delivery
systems,
physicochemical
methods,
unconventional
techniques,
including
CRISPR-Cas
system.
may
change
treatment
multi-drug-resistant
pathogens
human
clinical
settings.
Microorganisms,
Journal Year:
2022,
Volume and Issue:
10(9), P. 1778 - 1778
Published: Sept. 3, 2022
The
growing
increase
in
antibiotic-resistant
bacteria
has
led
to
the
search
for
new
antibacterial
agents
capable
of
overcoming
resistance
problem.
In
recent
years,
nanoparticles
(NPs)
have
been
increasingly
used
target
as
an
alternative
antibiotics.
most
promising
nanomaterials
biomedical
applications
are
metal
and
oxide
NPs,
due
their
intrinsic
activity.
Although
NPs
show
interesting
properties,
mechanisms
underlying
action
still
poorly
understood,
limiting
use
clinical
applications.
this
review,
overview
activity
will
be
provided,
relating
efficacy
to:
(i)
bacterial
strain;
(ii)
higher
microbial
organizations
(biofilm);
(iii)
physico-chemical
properties
NPs.
addition,
strategies
also
discussed
better
evaluate
feasibility
different
treatments
adopted
safety
fields.
Finally,
a
wide
analysis
on
with
provided.
Rendiconti lincei. Scienze fisiche e naturali,
Journal Year:
2022,
Volume and Issue:
33(3), P. 527 - 536
Published: Aug. 9, 2022
Abstract
Biofilm
is
the
most
successful
and
widely
distributed
form
of
life
on
earth,
it
not
simply
structured
collections
cells
attached
to
surfaces
but
a
dynamic
complex
biological
system
able
respond
environmental
changes.
The
biofilm
characteristics
make
unique
central
microbial
evolution
adaptation.
ability
establish
biofilms
key
trait
for
microorganisms
growing
in
extreme
environments
like
temperature,
high
radiation,
acidic
or
alkaline
pH
values,
heavy
metal
pollution,
salinity.
In
this
article,
we
report
main
features
how
these
survival
strategy
conditions.
All
aspects
examined
article
help
explain
why
are
conditions
environments.
Communications Biology,
Journal Year:
2022,
Volume and Issue:
5(1)
Published: May 26, 2022
Abstract
The
genetic
capacity
to
synthesize
the
biofilm
matrix
exopolysaccharide
Pel
is
widespread
among
Gram-negative
and
Gram-positive
bacteria.
However,
its
exact
chemical
structure
has
been
challenging
determine.
Using
a
Pseudomonas
aeruginosa
strain
engineered
overproduce
Pel,
improvements
isolation
procedure,
selective
hydrolysis
with
glycoside
hydrolase
PelA
h
,
we
demonstrate
that
partially
de-
N-
acetylated
linear
polymer
of
α-1,4-
acetylgalactosamine
comprised
predominantly
dimeric
repeats
galactosamine
acetylgalactosamine.
