Medicine in Microecology,
Journal Year:
2024,
Volume and Issue:
22, P. 100111 - 100111
Published: Aug. 25, 2024
Probiotics
are
microbes
associated
with
a
wide
range
of
health
benefits
and
modulate
gut
flora
by
releasing
effector
molecules.
The
efficacy
probiotics
at
various
stages
cancer
treatment
has
been
well
demonstrated.
can
increase
the
potency
cancer-based
immunotherapy,
which
be
administered
before,
during,
or
post-phase
therapy.
consumption
among
patients
minimize
detrimental
effects
chemotherapy
act
as
potential
tool
for
Genetically
engineered
express
specific
antigens
that
combat
deadly
pathogens.
These
essential
features
utilized
in
other
applications.
This
review
aims
to
provide
updated
information
on
mechanism
action
their
applications
Moreover,
few
significant
like;
antioxidative
therapy,
biotechnology-based
improvement,
developing
potent
probiotic
strains
effective
also
discussed.
Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Journal Year:
2024,
Volume and Issue:
unknown, P. 391 - 418
Published: Aug. 28, 2024
Cancer
immunotherapy
has
emerged
as
a
revolutionary
approach
in
the
fight
against
cancer.
Unlike
traditional
treatments
like
chemotherapy
and
radiation,
harnesses
power
of
body's
own
immune
system
to
identify
destroy
cancer
cells.
promising
therapy,
but
limitations
specificity
control
hinder
its
full
potential.
Synthetic
gene
circuits
offer
address
these
challenges.
This
chapter
emphasizes
diverse
applications
synthetic
immunotherapy.
Additionally,
authors
discuss
advantages
AND
gate
for
minimizing
off-target
effects,
engineered
bacteria
targeted
tumour
manipulation,
T-cell
engineering
enhanced
anti-tumour
activity.
Ultimately,
therapies
are
not
mutually
exclusive.
While
proven
effectiveness
accessibility,
hold
immense
promise
personalized,
long-term
solutions.
ACS Synthetic Biology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 10, 2025
Bacteriophages,
leveraging
phage
display
and
chemical
modification,
have
the
potential
to
deliver
large
payloads
of
antitumor
agents
with
precision
advance
vaccine
development.
However,
systemic
administration
often
induces
neutralizing
antibodies,
which
accelerate
clearance
reduce
accumulation
at
target
site.
To
address
this
limitation,
we
propose
a
genetically
modified
nonpathogenic
bacterial
strain
that
specifically
targets
tumors
releases
programmed
death
ligand
1
(PD-L1)-specific
M13
bacteriophage
within
tumor
tissue.
We
assessed
efficacy
phage-expressing
as
an
adjunctive
therapeutic
strategy
along
engineered
for
controlled
release
immunotoxin.
The
combination
these
strains
demonstrated
synergistic
effects
in
eliciting
immune
responses
inhibiting
growth
murine
model
colorectal
cancer
(CRC).
Moreover,
when
combined
Folfox,
significantly
extended
survival.
This
vivo
expression
tumor-specific
mediated
by
provides
effective
safe
method
targeted
delivery
tumors.
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(6), P. 2040 - 2040
Published: March 17, 2025
Oncologists
increasingly
recognize
the
microbiome
as
an
important
facilitator
of
health
well
a
contributor
to
disease,
including,
specifically,
cancer.
Our
knowledge
etiologies,
mechanisms,
and
modulation
states
that
ameliorate
or
promote
cancer
continues
evolve.
The
progressive
refinement
adoption
“omic”
technologies
(genomics,
transcriptomics,
proteomics,
metabolomics)
utilization
advanced
computational
methods
accelerate
this
evolution.
academic
center
network,
with
its
immediate
access
extensive,
multidisciplinary
expertise
scientific
resources,
has
potential
catalyze
research.
Here,
we
review
our
current
understanding
role
gut
in
prevention,
predisposition,
response
therapy.
We
underscore
promise
operationalizing
network
uncover
structure
function
microbiome;
highlight
unique
microbiome-related
expert
resources
available
at
City
Hope
Comprehensive
Cancer
Center
example
team
science
achieve
novel
clinical
discovery.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 3827 - 3846
Published: April 1, 2024
Background:
New
treatment
modalities
for
hepatocellular
carcinoma
(HCC)
are
desperately
critically
needed,
given
the
lack
of
specificity,
severe
side
effects,
and
drug
resistance
with
single
chemotherapy.Engineered
bacteria
can
target
accumulate
in
tumor
tissues,
induce
an
immune
response,
act
as
delivery
vehicles.However,
conventional
bacterial
therapy
has
limitations,
such
loading
capacity
difficult
cargo
release,
resulting
inadequate
therapeutic
outcomes.Synthetic
biotechnology
enhance
precision
efficacy
bacteria-based
systems.This
enables
selective
release
payloads
vivo.Methods:
In
this
study,
we
constructed
a
non-pathogenic
Escherichia
coli
(E.coli)
synchronized
lysis
circuit
both
drug/
gene
vehicle
in-situ
(hepatitis
B
surface
antigen)
Ag
(ASEc)
producer.Polyethylene
glycol
(CHO-PEG
2000
-CHO)-poly
(ethyleneimine)
(PEI
25k
)-citraconic
anhydride
(CA)-doxorubicin
(DOX)
nanoparticles
loaded
plasmid
encoded
human
sulfatase
1
(hsulf-1)
enzyme
(PNPs)
were
anchored
on
ASEc
(ASEc@PNPs).The
composites
synthesized
characterized.The
vitro
vivo
anti-tumor
effect
ASEc@PNPs
was
tested
HepG2
cell
lines
mouse
subcutaneous
model.
Results:The
results
demonstrated
that
upon
intravenous
injection
into
tumor-bearing
mice,
actively
colonise
sites.The
lytic
genes
to
achieve
blast
concentrated
significantly
increased
cytokine
secretion
intratumoral
infiltration
CD4/CD8
+
T
cells,
initiated
specific
response.Simultaneously,
PNPs
system
releases
hsulf-1
DOX
rapid
regression
metastasis
prevention.
Conclusion:The
novel
suppressed
HCC
reduced
indicating
potential
strategy
clinical
therapy.
Biotechnology Journal,
Journal Year:
2024,
Volume and Issue:
19(8)
Published: Aug. 1, 2024
Abstract
Microalgae
are
a
group
of
microorganisms
containing
chlorophyll
A,
which
highly
photosynthetic
and
rich
in
nutrients.
And
they
can
produce
multiple
bioactive
substances
(peptides,
proteins,
polysaccharides,
fatty
acids)
for
biomedical
applications.
Despite
the
unique
advantages
microalgae‐based
biotherapy,
insufficient
treatment
efficiency
limits
its
further
application.
With
development
nanotechnology,
combination
microalgae
biomaterials
improve
therapeutic
efficacies,
has
attracted
increasing
attention.
In
this
microalgal‐biomaterials
hybrid
system,
with
excellent
optical
magnetic
properties
play
an
important
role
biological
therapy.
Microalgae,
as
natural
vehicle,
increase
oxygen
content
alleviate
hypoxia
diseased
areas,
enhancing
effects.
review,
synergistic
effects
system
different
diseases
(cancer,
myocardial
infarction,
ischemia
stroke,
chronic
infection,
intestinal
diseases)
comprehensively
summarized.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 19, 2024
The
development
of
an
engineered
RNA
device
capable
detecting
multiple
biomarkers
to
evaluate
pathological
states
and
autonomously
implement
responsive
therapies
is
urgently
needed.
Here,
we
report
InCasApt,
integrated
nano
CRISPR
Cas13a/RNA
aptamer
theranostic
platform
achieving
both
biomarker
detection
biomarker-driven
therapy.
Within
this
system,
a
Cas13a/crRNA
complex,
hairpin
reporter
(HR),
dinitroaniline
caged
Ce6
photosensitizer
(Ce6-DN),
DN-binding
precursor
(DNBApt)
are
coloaded
onto
dendritic
mesoporous
silicon
nanoparticles
(DMSN)
in
controlled
manner.
While
InCasApt
remains
inert
normal
cells,
its
programmable
capabilities
activated
tumor
cells
that
have
elevated
expression
carcinogenic
miRNA-155
miRNA-21.
These
miRNAs
act
as
AND
logic
gate,
generating
fluorescence
for
disease
condition
evaluation
ROS
photodynamic
This
process
also
upregulates
antioncogene
BRG1
suppresses
migration
by
inhibiting
the
function
effects
underscore
versatility
miRNA-targeting
strategy
bridging
gap
between
diagnosis
