Apmis,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 4, 2024
Oral
candidiasis
(OC),
a
prevalent
opportunistic
infection
of
the
oral
mucosa,
presents
considerable
health
challenge,
particularly
in
individuals
with
compromised
immune
responses,
advanced
age,
and
local
predisposing
conditions.
A
part
population
carries
Candida
cavity,
but
only
few
develop
OC.
Therefore,
pathogenesis
OC
may
depend
on
factors
other
than
attributes
fungus,
such
as
host
factors.
Mucosal
trauma
inflammation
compromise
epithelial
integrity,
fostering
conducive
environment
for
fungal
invasion.
Molecular
insights
into
immunocompromised
state
reveal
dysregulation
innate
adaptive
immunity,
creating
permissive
proliferation.
Detailed
examination
species
(spp.)
their
virulence
uncovers
nuanced
understanding
beyond
traditional
C.
albicans
focus,
which
embrace
diverse
spp.
strategies,
influencing
adhesion,
invasion,
evasion,
biofilm
formation.
Understanding
pathophysiological
microenvironments
is
crucial
development
targeted
therapeutic
interventions.
This
review
aims
to
unravel
focusing
microbial,
host,
factors,
considers
resistance
antifungal
therapy.
The
comprehensive
approach
offers
refined
perspective
OC,
seeking
briefly
identify
potential
targets
future
effective
management.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(5), P. 2756 - 2756
Published: March 2, 2022
Despite
abundant
research
in
the
field
of
antifungal
drug
discovery,
fungal
infections
remain
a
significant
healthcare
burden.
There
is
an
emerging
need
for
development
novel
antifungals
since
those
currently
available
are
limited
and
do
not
completely
provide
safe
secure
protection.
Since
current
knowledge
regarding
physiology
cells
infection
mechanisms
greater
than
ever,
we
have
opportunity
to
use
this
generations
antifungals.
In
review,
selected
summarized
recent
studies
describing
agents
employing
different
mechanisms.
These
include
interference
with
resistance,
including
impact
on
efflux
pumps
heat
shock
protein
90.
Additionally,
virulence
factors,
such
as
biofilms
hyphae;
enzymes,
metabolism,
mitochondria,
cell
wall;
vaccines
explored.
The
investigated
belong
classes
natural
or
synthetic
molecules
attention
given
also
plant
extracts.
efficacy
these
has
been
studied
mainly
vitro
some
vivo,
clinical
needed.
Nevertheless,
there
large
quantity
products
that
can
be
further
explored
new
generation
Journal of Fungi,
Journal Year:
2023,
Volume and Issue:
9(5), P. 565 - 565
Published: May 12, 2023
Antifungal
resistance
is
a
growing
concern
as
it
poses
significant
threat
to
public
health.
Fungal
infections
are
cause
of
morbidity
and
mortality,
especially
in
immunocompromised
individuals.
The
limited
number
antifungal
agents
the
emergence
have
led
critical
need
understand
mechanisms
drug
resistance.
This
review
provides
an
overview
importance
resistance,
classes
agents,
their
mode
action.
It
highlights
molecular
including
alterations
modification,
activation,
availability.
In
addition,
discusses
response
drugs
via
regulation
multidrug
efflux
systems
drug–target
interactions.
We
emphasize
understanding
develop
effective
strategies
combat
highlight
for
continued
research
identify
new
targets
development
explore
alternative
therapeutic
options
overcome
Overall,
its
will
be
indispensable
field
clinical
management
fungal
infections.
Journal of Fungi,
Journal Year:
2023,
Volume and Issue:
9(2), P. 171 - 171
Published: Jan. 28, 2023
Due
to
their
eukaryotic
heritage,
the
differences
between
a
fungal
pathogen’s
molecular
makeup
and
its
human
host
are
small.
Therefore,
discovery
subsequent
development
of
novel
antifungal
drugs
extremely
challenging.
Nevertheless,
since
1940s,
researchers
have
successfully
uncovered
potent
candidates
from
natural
or
synthetic
sources.
Analogs
formulations
these
enhanced
pharmacological
parameters
improved
overall
drug
efficiency.
These
compounds
ultimately
became
founding
members
classes
were
applied
in
clinical
settings,
offering
valuable
efficient
treatment
mycosis
for
decades.
Currently,
only
five
different
exist,
all
characterized
by
unique
mode
action;
polyenes,
pyrimidine
analogs,
azoles,
allylamines,
echinocandins.
The
latter,
being
latest
addition
armamentarium,
was
introduced
over
two
decades
ago.
As
result
this
limited
arsenal,
resistance
has
exponentially
increased
and,
with
it,
growing
healthcare
crisis.
In
review,
we
discuss
original
sources
compounds,
either
synthetic.
Additionally,
summarize
existing
classes,
potential
pipeline,
emerging
non-traditional
options.
Fungal Diversity,
Journal Year:
2024,
Volume and Issue:
125(1), P. 1 - 71
Published: March 20, 2024
Abstract
The
field
of
mycology
has
grown
from
an
underappreciated
subset
botany,
to
a
valuable,
modern
scientific
discipline.
As
this
study
grown,
there
have
been
significant
contributions
science,
technology,
and
industry,
highlighting
the
value
fungi
in
era.
This
paper
looks
at
current
research,
along
with
existing
limitations,
suggests
future
areas
where
scientists
can
focus
their
efforts,
mycology.
We
show
how
become
important
emerging
diseases
medical
discuss
trends
potential
drug
novel
compound
discovery.
explore
phylogenomics,
its
potential,
outcomes
address
question
phylogenomics
be
applied
fungal
ecology.
In
addition,
functional
genomics
studies
are
discussed
importance
unravelling
intricate
mechanisms
underlying
behaviour,
interactions,
adaptations,
paving
way
for
comprehensive
understanding
biology.
look
research
building
materials,
they
used
as
carbon
sinks,
biocircular
economies.
numbers
always
great
interest
often
written
about
estimates
varied
greatly.
Thus,
we
needs
order
obtain
more
reliable
estimates.
aspects
machine
learning
(AI)
it
mycological
research.
Plant
pathogens
affecting
food
production
systems
on
global
scale,
such,
needed
area,
particularly
disease
detection.
latest
data
High
Throughput
Sequencing
if
still
gaining
new
knowledge
same
rate
before.
A
review
nanotechnology
is
provided
addressed.
Arbuscular
Mycorrhizal
Fungi
addressed
acknowledged.
Fungal
databases
becoming
important,
therefore
provide
major
databases.
Edible
medicinal
huge
medicines,
especially
Asia
prospects
discussed.
Lifestyle
changes
(e.g.,
endophytes,
pathogens,
and/or
saprobes)
also
extremely
trend
special
issue
Diversity.
Clinical Microbiology Reviews,
Journal Year:
2024,
Volume and Issue:
37(1)
Published: Jan. 31, 2024
SUMMARY
Over
recent
decades,
the
global
burden
of
fungal
disease
has
expanded
dramatically.
It
is
estimated
that
kills
approximately
1.5
million
individuals
annually;
however,
true
worldwide
infection
thought
to
be
higher
due
existing
gaps
in
diagnostics
and
clinical
understanding
mycotic
disease.
The
development
resistance
antifungals
across
diverse
pathogenic
genera
an
increasingly
common
devastating
phenomenon
dearth
available
antifungal
classes.
These
factors
necessitate
a
coordinated
response
by
researchers,
clinicians,
public
health
agencies,
pharmaceutical
industry
develop
new
strategies,
as
continues
grow.
This
review
provides
comprehensive
overview
therapeutics
currently
trials,
highlighting
their
spectra
activity
progress
toward
implementation.
We
also
profile
up-and-coming
intracellular
proteins
pathways
primed
for
novel
targeting
activity.
Ultimately,
we
aim
emphasize
importance
increased
investment
into
current
continually
evolving
landscape
infectious
