Engineering nanomedicine for glutathione depletion-augmented cancer therapy

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(10), P. 6013 - 6041

Published: Jan. 1, 2021

In this review, we systematically survey the most recent progress in engineering nanomedicine for intracellular glutathione consumption-augmented cancer therapy.

Language: Английский

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GSH‐Depleted PtCu₃ Nanocages for Chemodynamic‐ Enhanced Sonodynamic Cancer Therapy

Advanced Functional Materials, Journal Year: 2019, Volume and Issue: 30(4)

Published: Nov. 13, 2019

Abstract The ultrahigh concentration of glutathione (GSH) inside tumors destroys reactive oxygen species (ROS)‐based therapy, improving the outcome chemodynamic therapy (CDT)‐enhanced sonodynamic (SDT) by depleting GSH is full great challenge. Herein, PtCu 3 nanocages are first reported as acting a sonosensitizer with highly efficient ROS generation under ultrasound irradiation. In addition, can act horseradish peroxidase‐like nanozymes, catalyzing decomposition H 2 O into • OH acidic conditions for CDT. Surprisingly, another kind nanozyme, mimicking peroxidase (GSH‐Px), which plays an important role in accelerating depletion oxidizing molecules, further weakening capacity tumor cells scavenging GSH. Both vitro and vivo studies demonstrate that perform well reducing level CDT‐enhanced SDT. Moreover, utilizing high absorption near‐infrared region strong X‐ray attenuation ability, able to conduct photoacoustic/computed tomography dual‐modal imaging‐guided combined cancer therapy. It worth mentioning cause minimal toxicity normal tissues at therapeutic doses. This work highlights use effective SDT via depletion.

Language: Английский

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Multifunctional biomolecule nanostructures for cancer therapy

Nature Reviews Materials, Journal Year: 2021, Volume and Issue: 6(9), P. 766 - 783

Published: May 19, 2021

Language: Английский

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Extracellular vesicle-based drug delivery systems for cancer treatment

Theranostics, Journal Year: 2019, Volume and Issue: 9(26), P. 8001 - 8017

Published: Jan. 1, 2019

Extracellular vesicles (EVs) are naturally occurring cell-secreted nanoparticles that play important roles in many physiological and pathological processes. EVs enable intercellular communication by serving as delivery vehicles for a wide range of endogenous cargo molecules, such RNAs, proteins, carbohydrates, lipids. have also been found to display tissue tropism mediated surface integrins glycans, making them promising drug applications. Various methods can be used load therapeutic agents into EVs, additional modification strategies employed prolong circulation improve targeting. This review gives an overview EV-based cancer therapy.

Language: Английский

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Role of Nanoparticle Mechanical Properties in Cancer Drug Delivery

ACS Nano, Journal Year: 2019, Volume and Issue: 13(7), P. 7410 - 7424

Published: July 9, 2019

The physicochemical properties of nanoparticles play critical roles in regulating nano-bio interactions. Whereas the effects size, shape, and surface charge on their biological performances have been extensively investigated, nanoparticle mechanical drug delivery, which only recognized recently, remain least explored. This review article provides an overview impacts cancer including (1) basic terminologies techniques for characterizing these properties; (2) current methods fabricating with tunable (3) vitro vivo studies that highlight key stiff soft nanoparticles, blood circulation, tumor or tissue targeting, penetration, cell internalization, a special emphasis underlying mechanisms control those complicated interactions at cellular, tissue, organ levels. interesting research findings discussed this will offer community better understanding how field evolved during past years provide some general guidance to design explore These fundamental understandings, turn, improve our ability enhanced delivery.

Language: Английский

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Responsive Exosome Nano‐bioconjugates for Synergistic Cancer Therapy

Angewandte Chemie International Edition, Journal Year: 2019, Volume and Issue: 59(5), P. 2018 - 2022

Published: Nov. 20, 2019

Abstract Exosomes hold great potential in therapeutic development. However, native exosomes usually induce insufficient effects vivo and simply act as drug delivery vehicles. Herein, we synthesize responsive exosome nano‐bioconjugates for cancer therapy. Azide‐modified derived from M1 macrophages are conjugated with dibenzocyclooctyne‐modified antibodies of CD47 SIRPα (aCD47 aSIRPα) through pH‐sensitive linkers. After systemic administration, the can actively target tumors specific recognition between aCD47 on tumor cell surface. In acidic microenvironment, benzoic‐imine bonds cleaved to release aSIRPα that can, respectively, block CD47, leading abolished “don't eat me” signaling improved phagocytosis macrophages. Meanwhile, effectively reprogram pro‐tumoral M2 anti‐tumoral M1.

Language: Английский

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Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Jan. 19, 2021

Abstract The main challenges for programmed cell death 1(PD-1)/PD-1 ligand (PD-L1) checkpoint blockade lie in a lack of sufficient T infiltration, tumor immunosuppressive microenvironment, and the inadequate accumulation penetration anti-PD-1/PD-L1 antibody. Resetting tumor-associated macrophages (TAMs) is promising strategy to enhance T-cell antitumor immunity ameliorate immunosuppression. Here, mannose-modified macrophage-derived microparticles (Man-MPs) loading metformin (Met@Man-MPs) are developed efficiently target M2-like TAMs repolarize into M1-like phenotype. Met@Man-MPs-reset remodel immune microenvironment by increasing recruitment CD8 + cells tissues decreasing infiltration myeloid-derived suppressor regulatory cells. More importantly, collagen-degrading capacity Man-MPs contributes interiors enhances anti-PD-1 These unique features Met@Man-MPs contribute boost antibody therapy, improving anticancer efficacy long-term memory after combination treatment. Our results support as potential drug improve resistance therapy.

Language: Английский

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Recent progress in targeted delivery vectors based on biomimetic nanoparticles

Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)

Published: June 7, 2021

Abstract Over the past decades, great interest has been given to biomimetic nanoparticles (BNPs) since rise of targeted drug delivery systems and nanotechnology. Biological vectors including cell membranes, extracellular vesicles (EVs), viruses are considered promising candidates for owing their biocompatibility biodegradability. BNPs, integration biological functional agents, anticipated load cargos or camouflage synthetic achieve delivery. Despite excellent intrinsic properties, natural deliberately modified endow multiple functions such as good permeability, improved loading capability, high specificity. Through structural modification transformation vectors, they pervasively utilized more effective vehicles that can deliver contrast chemotherapy drugs, nucleic acids, genes target sites refractory disease therapy. This review summarizes recent advances in based on EVs, viruses, highlighting potential applications BNPs fields biomedical imaging therapy industry, well discussing possibility clinical translation exploitation trend these BNPs.

Language: Английский

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Targeted doxorubicin-loaded mesenchymal stem cells-derived exosomes as a versatile platform for fighting against colorectal cancer

Life Sciences, Journal Year: 2020, Volume and Issue: 261, P. 118369 - 118369

Published: Aug. 31, 2020

Language: Английский

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Applications of Surface Modification Technologies in Nanomedicine for Deep Tumor Penetration

Advanced Science, Journal Year: 2020, Volume and Issue: 8(1)

Published: Nov. 27, 2020

The impermeable barrier of solid tumors due to the complexity their components limits treatment effect nanomedicine and hinders its clinical translation. Several methods are available increase penetrability nanomedicine, yet they too complex be effective, operational, or practical. Surface modification employs characteristics direct contact between multiphase surfaces achieve most efficient penetration tumors. Furthermore, simple operation makes use feasible. In this review, latest surface strategies for into summarized classified "bulldozer strategies" "mouse strategies." Additionally, evaluation methods, existing problems, development prospects these technologies discussed.

Language: Английский

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