Disturbing cytoskeleton by engineered nanomaterials for enhanced cancer therapeutics DOI Creative Commons

Xueli Xu,

Shanbin Xu,

Jipeng Wan

et al.

Bioactive Materials, Journal Year: 2023, Volume and Issue: 29, P. 50 - 71

Published: June 29, 2023

Cytoskeleton plays a significant role in the shape change, migration, movement, adhesion, cytokinesis, and phagocytosis of tumor cells. In clinical practice, some anti-cancer drugs achieve cytoskeletal therapeutic effects by acting on different protein components. However, absence cell-specific targeting, unnecessary recombination organisms would be disastrous, which also bring about severe side during anticancer process. Nanomedicine have been proven to superior small molecule cancer treatment due better stability lower effects. Therefore, this review summarized recent developments various nanomaterials disturbing cytoskeleton for enhanced therapeutics, including carbon, noble metals, metal oxides, black phosphorus, calcium, silicon, polymers, peptides, metal-organic frameworks, etc. A comprehensive analysis characteristics therapy as well future prospects challenges towards application were discussed. We aim drive emerging topic through refreshing perspectives based our own work what we learnt from others. This will help researchers quickly understand relevant information further advance development nanomedicine.

Language: Английский

Self-assembled inorganic chiral superstructures DOI
Jiawei Lv, Xiaoqing Gao, Bing Han

et al.

Nature Reviews Chemistry, Journal Year: 2022, Volume and Issue: 6(2), P. 125 - 145

Published: Jan. 17, 2022

Language: Английский

Citations

176

Hierarchical self-assembly into chiral nanostructures DOI Creative Commons
Yutao Sang, Minghua Liu

Chemical Science, Journal Year: 2021, Volume and Issue: 13(3), P. 633 - 656

Published: Nov. 9, 2021

This review shows how chirality may be used for the design, construction and evolution of higher ordered complex chiral nanostructures through hierarchical self-assembly.

Language: Английский

Citations

127

Chiral Plasmonic Triangular Nanorings with SERS Activity for Ultrasensitive Detection of Amyloid Proteins in Alzheimer's Disease DOI
Gaoyang Wang,

Changlong Hao,

Wei Ma

et al.

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(38)

Published: July 26, 2021

Abstract Chiral plasmonic nanomaterials have attracted unprecedented attention due to their broad applications in biomedicine, negative refractive index, and chiral sensing. Here, using a wet‐chemistry process, triangular Au nanorings are fabricated with platinum (Pt) framework ( l / d ‐Pt@Au nanorings, named TNRs). The TNRs exhibit strong optical activity g ‐factor of 0.023 can be used effectively for the discrimination enantiomers selective resonance coupling between induced electric magnetic dipoles associated TNRs, also known as surface‐enhanced Raman scattering‐chiral anisotropy (SERS‐ChA) effect. represent label‐free SERS platform that applied detect Aβ monomers fibrils, hallmarks Alzheimer's disease (AD), achieving limit detection (LOD) down 0.045 × 10 −12 m 4 −15 42‐residue‐long amyloid‐β (Aβ 42 ) monomer respectively. Furthermore, successfully carried out proteins AD patients ultrahigh levels sensitivity, thus allowing picogram quantities identified. This research opens up an avenue use ultrasensitive substrates early diagnosis protein‐misfolding diseases.

Language: Английский

Citations

121

Gold nanostructures: synthesis, properties, and neurological applications DOI
Iman Zare, Mohammad Tavakkoli Yaraki, G. Speranza

et al.

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(7), P. 2601 - 2680

Published: Jan. 1, 2022

Recent advances in nanotechnology are expected to increase our current understanding of neuroscience.

Language: Английский

Citations

82

Nanoparticle Self-Assembly: From Design Principles to Complex Matter to Functional Materials DOI
Anish Rao, Sumit Roy, Vanshika Jain

et al.

ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 15(21), P. 25248 - 25274

Published: June 17, 2022

The creation of matter with varying degrees complexities and desired functions is one the ultimate targets self-assembly. ability to regulate complex interactions between individual components essential in achieving this target. In direction, initial success controlling pathways final thermodynamic states a self-assembly process promising. Despite progress made field, there has been growing interest pushing limits processes. main inception that intended self-assembled state, complexities, may not be "at equilibrium (or at global minimum)", rendering free energy minimization unsuitable form product. Thus, we believe thorough understanding design principles as well predict outcome collection next generation matter. present review highlights potent role finely tuned interparticle nanomaterials achieve preferred structures properties. We bringing prediction nanoparticle processes will have similar effect retrosynthesis had on logic chemical synthesis. Along guiding principles, gives summary different types products created from assemblies functional properties emerging them. Finally, highlight reasonable expectations field challenges lying ahead evolvable

Language: Английский

Citations

72

Circularly Polarized Light Responsive Materials: Design Strategies and Applications DOI
Yiping Liu, Pengyao Xing

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(49)

Published: March 19, 2023

Abstract Circularly polarized light (CPL) with the end of optical vector traveling along circumferential trajectory shows left‐ and right‐handedness, which transmits chiral information to materials via complicated CPL–matter interactions. Materials circular dichroism respond CPL illumination selectively differential outputs that can be used design novel photodetectors. Racemic or achiral compounds under go through photodestruction, photoresolution, asymmetric synthesis pathways generate enantiomeric bias activity. By this strategy, helical polymers inorganic plasmonic nanostructures are synthesized directly, their intramolecular folding subsequent self‐assembly photomodulable as well. In aggregated state liquid crystal phase, sense dynamic molecular packing is sensitive brought by CPL, enabling amplification supramolecular scale. review, application‐guided strategies CPL‐responsive aimed systematically summarized discussed. Asymmetric synthesis, resolution, property‐modulation small organic compounds, polymers, nanoparticles, assemblies crystals highlighted based on important developments during last decades. Besides, applications light–matter interactions including detection biomedical also referred.

Language: Английский

Citations

66

Circularly Polarized Light-Enabled Chiral Nanomaterials: From Fabrication to Application DOI Creative Commons

Changlong Hao,

Gaoyang Wang, Chen Chen

et al.

Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 15(1)

Published: Jan. 18, 2023

Abstract For decades, chiral nanomaterials have been extensively studied because of their extraordinary properties. Chiral nanostructures attracted a lot interest potential applications including biosensing, asymmetric catalysis, optical devices, and negative index materials. Circularly polarized light (CPL) is the most attractive source for chirality owing to its high availability, now it has used as preparation matter. In this review, recent progress in field CPL-enabled summarized. Firstly, advancements fabrication materials using circularly are described, focusing on unique strategies. Secondly, an overview driven by CPL provided, with particular emphasis phototherapy. Finally, perspective challenges given.

Language: Английский

Citations

52

Regulation of biological processes by intrinsically chiral engineered materials DOI
Baojin Ma, Alberto Bianco

Nature Reviews Materials, Journal Year: 2023, Volume and Issue: 8(6), P. 403 - 413

Published: May 17, 2023

Language: Английский

Citations

50

Circularly polarized luminescence polymers: From design to applications DOI
Shijie Yang,

Shu-Ming Zhang,

Fengqing Hu

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 485, P. 215116 - 215116

Published: March 28, 2023

Language: Английский

Citations

49

Bright Circularly Polarized Mechanoluminescence from 0D Hybrid Manganese Halides DOI
Xin He,

Yuantian Zheng,

Zhishan Luo

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(15)

Published: Jan. 17, 2024

Hybrid metal halides (HMHs) with efficient circularly polarized luminescence (CPL) have application prospects in many fields, due to their abundant host-guest structures and high photoluminescence quantum yield (PLQY). However, CPLs HMHs are predominantly excited by light or electricity, limiting use multivariate environments. It is necessary explore a novel excitation method extend the of chiral as smart stimuli-responsive optical materials. In this work, an enantiomeric pair 0D hybrid manganese bromides, [H

Language: Английский

Citations

26