Smart Nanocarriers for the Treatment of Retinal Diseases DOI
Shuya Liu,

Zhike Yan,

Zixiang Huang

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(4), P. 2070 - 2085

Published: March 15, 2024

Retinal diseases, such as age-related macular degeneration, diabetic retinopathy, and retinoblastoma, stand the leading causes of irreversible vision impairment blindness worldwide. Effectively administering drugs for retinal diseases poses a formidable challenge due to presence complex ocular barriers elimination mechanisms. Over time, various approaches have been developed fabricate drug delivery systems improving therapy including virus vectors, lipid nanoparticles, polymers. However, conventional nanocarriers encounter issues related controllability, efficiency, safety in retina. Therefore, development smart effective or more invasive long-term treatment remains desirable goal. Recently, surfaced intelligent design nanocarriers, leveraging specific responses external internal triggers enabling multiple functions topical administration, prolonged release, site-specific delivery. This Review provides an overview prevalent pathologies pharmacotherapies enhance understanding diseases. It also surveys recent developments strategies employed disease. Finally, challenges potential clinical therapeutic applications are discussed inspire next generation nanocarriers.

Language: Английский

An NIR photothermal-responsive hybrid hydrogel for enhanced wound healing DOI
Lin Jin, Xiaoqing Guo, Di Gao

et al.

Bioactive Materials, Journal Year: 2022, Volume and Issue: 16, P. 162 - 172

Published: March 10, 2022

Language: Английский

Citations

122
Nanotechnology-based ocular drug delivery systems: recent advances and future prospects DOI Creative Commons

Shiding Li,

Liangbo Chen, Yao Fu

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: July 22, 2023

Abstract Ocular drug delivery has constantly challenged ophthalmologists and scientists due to various anatomical physiological barriers. Static dynamic ocular barriers prevent the entry of exogenous substances impede therapeutic agents' active absorption. This review elaborates on anatomy eye associated constraints. Followed by an illustration some common diseases, including glaucoma their current clinical therapies, emphasizing significance therapy in treating diseases. Subsequently, advances modalities, especially nanotechnology-based systems, are recommended, typical research is highlighted. Based related research, systematic comprehensive characterizations nanocarriers summarized, hoping assist with future research. Besides, we summarize ophthalmic drugs currently market or still trials recent patents nanocarriers. Finally, inspired trends concepts, provide insight into challenges faced novel systems further put forward directions for We hope this can inspiration motivation better design development formulations. Graphical abstract

Language: Английский

Citations

95
The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in diabetic retinopathy DOI Creative Commons
Xiaoqin Zheng,

Jia Wan,

Gang Tan

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: April 25, 2023

In the working-age population worldwide, diabetic retinopathy (DR), a prevalent complication of diabetes, is main cause vision impairment. Chronic low-grade inflammation plays an essential role in DR development. Recently, concerning pathogenesis DR, Nod-Like Receptor Family Pyrin Domain Containing 3 (NLRP3) inflammasome retinal cells has been determined as causal factor. eye, NLRP3 activated by several pathways (such ROS and ATP). The activation NPRP3 leads to secretion inflammatory cytokines interleukin-1β (IL-1β) interleukin-18 (IL-18), pyroptosis, rapid form lytic programmed cell death (PCD). Cells that undergo pyroptosis swell rapture, releasing more factors accelerating progression. This review focuses on mechanisms activate leading DR. present research highlighted some inhibitors NLRP3/pyroptosis novel therapeutic measures treatment.

Language: Английский

Citations

57
Engineered Mesenchymal Stromal Cell Exosomes-Loaded Microneedles Improve Corneal Healing after Chemical Injury DOI
Fei Yu, Xuan Zhao, Qian Wang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(31), P. 20065 - 20082

Published: July 24, 2024

Corneal alkali burns represent a prevalent ophthalmic emergency with the potential to induce blindness. The main contributing mechanisms include excessive inflammation and delayed wound healing. Existing clinical therapies have limitations, promoting exploration of alternative methods that offer improved efficacy reduced side effects. Adipose-derived stem cell-exosome (ADSC-Exo) has sustain immune homeostasis facilitate tissue regeneration. Nevertheless, natural ADSC-Exo lacks disease specificity exhibits limited bioavailability on ocular surface. In this study, we conjugated antitumor necrosis factor-α antibodies (aT) surface using matrix metalloproteinase-cleavable peptide chains create engineered aT–Exo synergistic both in vivo vitro assessments, demonstrated superior mitigating corneal injuries compared aT alone, unmodified exosomes, or simply mixed exosomes. cleavable conjugation notably enhanced healing alleviated more effectively. Simultaneously, developed poly(vinyl alcohol) microneedles (MNs) for precise sustained exosome delivery. results showcased therapeutic efficiency MNs conventional topical administration subconjunctival injection. Therefore, bioactive nanodrugs-loaded treatment presents promising strategy addressing diseases.

Language: Английский

Citations

19
Frontier applications of retinal nanomedicine: progress, challenges and perspectives DOI Creative Commons

Zhimin Tang,

Fuxiang Ye, Ni Ni

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 25, 2025

The human retina is a fragile and sophisticated light-sensitive tissue in the central nervous system. Unhealthy retinas can cause irreversible visual deterioration permanent vision loss. Effective therapeutic strategies are restricted to treatment or reversal of these conditions. In recent years, nanoscience nanotechnology have revolutionized targeted management retinal diseases. Pharmaceuticals, theranostics, regenerative medicine, gene therapy, prostheses indispensable for interventions been significantly advanced by nanomedical innovations. Hence, this review presents novel insights into use versatile nanomaterial-based nanocomposites frontier applications, including non-invasive drug delivery, theranostic contrast agents, nanoagents, stem cell-based optogenetics prostheses, which mainly reported within last 5 years. Furthermore, progress, potential challenges, future perspectives field highlighted discussed detail, may shed light on clinical translations ultimately, benefit patients with disorders.

Language: Английский

Citations

2
Reprogramming of T cell‐derived small extracellular vesicles using IL2 surface engineering induces potent anti‐cancer effects through miRNA delivery DOI
Dokyung Jung, Sanghee Shin, Sung‐Min Kang

et al.

Journal of Extracellular Vesicles, Journal Year: 2022, Volume and Issue: 11(12)

Published: Nov. 29, 2022

T cell-derived small extracellular vesicles (sEVs) exhibit anti-cancer effects. However, their potential should be reinforced to enhance clinical applicability. Herein, we generated interleukin-2-tethered sEVs (IL2-sEVs) from engineered Jurkat cells expressing IL2 at the plasma membrane via a flexible linker induce an autocrine effect. IL2-sEVs increased ability of CD8+ without affecting regulatory (Treg ) and down-regulated cellular exosomal PD-L1 expression in melanoma cells, causing sensitivity cell-mediated cytotoxicity. Its effect on was mediated by several IL2-sEV-resident microRNAs (miRNAs), whose expressions were upregulated effects IL2. Among miRNAs, miR-181a-3p miR-223-3p notably reduced protein levels cells. Interestingly, activity while suppressing Treg cell activity. inhibited tumour progression melanoma-bearing immunocompetent mice, but not immunodeficient mice. The combination existing drugs significantly improved efficacy decreasing vivo. Thus, are cancer immunotherapeutic agents that regulate both immune reprogramming miRNA levels.

Language: Английский

Citations

59
Wireless electrical stimulation at the nanoscale interface induces tumor vascular normalization DOI Creative Commons
Changhao Li,

Cairong Xiao,

Lizhen Zhan

et al.

Bioactive Materials, Journal Year: 2022, Volume and Issue: 18, P. 399 - 408

Published: March 28, 2022

Pathological angiogenesis frequently occurs in tumor tissue, limiting the efficiency of chemotherapeutic drug delivery and accelerating progression. However, traditional vascular normalization strategies are not fully effective limited by development resistance. Herein, inspired intervention endogenous bioelectricity vessel formation, we propose a wireless electrical stimulation therapeutic strategy, capable breaking bioelectric homeostasis within cells, to achieve normalization. Polarized barium titanate nanoparticles with high mechano-electrical conversion performance were developed, which could generate pulsed open-circuit voltage under low-intensity ultrasound. We demonstrated that significantly inhibited endothelial cell migration differentiation vitro. Interestingly, found angiogenesis-related eNOS/NO pathway was inhibited, be attributed destruction intracellular calcium ion gradient stimulation. In vivo tumor-bearing mouse model indicated normalized vasculature optimizing structure, enhancing blood perfusion, reducing leakage, restoring local oxygenation. Ultimately, anti-tumor efficacy combination treatment 1.8 times single doxorubicin group. This work provides strategy based on piezoelectric nanoparticles, is expected safe clinical adjuvant malignant tumors.

Language: Английский

Citations

43
Augmented cellular uptake and homologous targeting of exosome-based drug loaded IOL for posterior capsular opacification prevention and biosafety improvement DOI Creative Commons
Siqing Zhu, Huiying Huang, Dong Liu

et al.

Bioactive Materials, Journal Year: 2022, Volume and Issue: 15, P. 469 - 481

Published: Feb. 26, 2022

Posterior capsular opacification (PCO), the most common complication after cataract surgery, is caused by proliferation, migration and differentiation of residual lens epithelial cells (LECs) on surface intraocular (IOL). Although drug-loaded IOLs have been successfully developed, PCO prevention efficacy still limited due to lack targeting low bioavailability. In this investigation, an exosome-functionalized IOL was developed for effective utilizing homologous high biocompatibility exosome. The exosomes derived from LECs were collected load anti-proliferative drug doxorubicin (Dox) through electroporation then immobilized aminated electrostatic interaction. vitro experiments showed that significantly improved cellular uptake Dox@Exos achieved ability exosome, compared with free Dox, thus resulting in superior anti-proliferation effect. vivo animal investigations indicated Dox@Exos-IOLs effectively inhibited development excellent biocompatibility. We believe work will provide a strategy IOL.

Language: Английский

Citations

41
Surface-Engineered Extracellular Vesicles in Cancer Immunotherapy DOI Open Access
Vinith Johnson,

Sunil Vasu,

Uday Kumar Sukumar

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(10), P. 2838 - 2838

Published: May 19, 2023

Extracellular vesicles (EVs) are lipid bilayer-enclosed bodies secreted by all cell types. EVs carry bioactive materials, such as proteins, lipids, metabolites, and nucleic acids, to communicate elicit functional alterations phenotypic changes in the counterpart stromal cells. In cancer, cells secrete shape a tumor-promoting niche. Tumor-secreted mediate communications with immune that determine fate of anti-tumor therapeutic effectiveness. Surface engineering has emerged promising tool for modulation tumor microenvironments cancer immunotherapy. Modification EVs' surface various molecules, antibodies, peptides, can enhance their targeting specificity, immunogenicity, biodistribution, pharmacokinetics. The diverse approaches sought EV surfaces be categorized physical, chemical, genetic strategies. choice method depends on specific application desired outcome. Each its advantages disadvantages. This review lends bird's-eye view recent progress these respect rational implications immunomodulation (TME) from pro-tumorigenic anti-tumorigenic ones. strategies modulating TME using targeted EVs, advantages, current limitations, future directions discussed.

Language: Английский

Citations

39
Nanomaterial-based ophthalmic drug delivery DOI

Guocheng Xie,

Sisi Lin, Feng Wu

et al.

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 200, P. 115004 - 115004

Published: July 9, 2023

Language: Английский

Citations

39