Skin-Interfaced Wearable Sweat Sensors for Precision Medicine

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(8), P. 5049 - 5138

Published: March 27, 2023

Wearable sensors hold great potential in empowering personalized health monitoring, predictive analytics, and timely intervention toward healthcare. Advances flexible electronics, materials science, electrochemistry have spurred the development of wearable sweat that enable continuous noninvasive screening analytes indicative status. Existing major challenges include: improving extraction sensing capabilities, form factor device for minimal discomfort reliable measurements when worn, understanding clinical value biomarker discovery. This review provides a comprehensive outlines state-of-the-art technologies research strive to bridge these gaps. The physiology sweat, materials, biosensing mechanisms advances, approaches induction sampling are introduced. Additionally, design considerations system-level devices, spanning from strategies prolonged efficient powering wearables, discussed. Furthermore, applications, data commercialization efforts, challenges, prospects precision medicine

Language: Английский

---

Engineered Hemostatic Biomaterials for Sealing Wounds

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(15), P. 12864 - 12903

Published: June 22, 2022

Hemostatic biomaterials show great promise in wound control for the treatment of uncontrolled bleeding associated with damaged tissues, traumatic wounds, and surgical incisions. A surge interest has been directed at boosting hemostatic properties bioactive materials via mechanisms triggering coagulation cascade. wide variety biocompatible biodegradable applied to design platforms rapid blood coagulation. Recent trends agents emphasize chemical conjugation charged moieties biomacromolecules, physical incorporation blood-coagulating systems, superabsorbing either dry (foams) or wet (hydrogel) states. In addition, tough bioadhesives are emerging efficient sealing this Review, we highlight biomacromolecular approaches adopted develop materials. We discuss mechanistic pathways hemostasis along current standard experimental procedures characterization efficacy. Finally, potential clinical translation technologies, future trends, research opportunities development next-generation management.

Language: Английский

---

Biomedical polymers: synthesis, properties, and applications

Science China Chemistry, Journal Year: 2022, Volume and Issue: 65(6), P. 1010 - 1075

Published: April 24, 2022

Language: Английский

---

Wireless soft millirobots for climbing three-dimensional surfaces in confined spaces

Science Advances, Journal Year: 2022, Volume and Issue: 8(21)

Published: May 27, 2022

Wireless soft-bodied robots at the millimeter scale allow traversing very confined unstructured terrains with minimal invasion and safely interacting surrounding environment. However, existing untethered soft millirobots still lack ability of climbing, reversible controlled surface adhesion, long-term retention on three-dimensional (3D) surfaces, limiting their use in biomedical environmental applications. Here, we report a fundamental peeling-and-loading mechanism to climb 3D surfaces by using both soft-body deformation whole-body motion robot under external magnetic fields. This generic is implemented different adhesive footpad designs, allowing vertical inverted climbing diverse complex geometries properties. With unique designs that integrate microstructured adhesives tough bioadhesives, could achieve controllable adhesion friction wet including porcine tissues, which paves way for future inspection minimally invasive medicine

Language: Английский

---

An Injectable Rapid‐Adhesion and Anti‐Swelling Adhesive Hydrogel for Hemostasis and Wound Sealing

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(46)

Published: Aug. 19, 2022

Abstract Injectable hydrogel adhesives integrating both rapid adhesion to wet tissues and anti‐swelling in humid environments are highly desired for fast hemostasis wound sealing surgical applications. Herein, utilizing the synergistic effect of thermo‐sensitive shrinkable nano‐micelle gelators small molecular adhesive moieties, an injectable with rapid‐adhesion properties (RAAS hydrogel) is fabricated. The RAAS can undergo ultrafast gelation achieve within 2 s ultraviolet illumination exhibit outstanding performance non‐expansion volume during whole degradation process. It also presents good biocompatibility low risk hemolysis. Its demonstrated diverse hemorrhage models injuries liver, artery, heart, cranial vessel, brain cortex animals. Importantly, its stability internal environment maintain strong strength avoid compression injury spinal cord when applied dura sealing. These data suggest that holds potential applications benefits stable reducing tissue injury.

Language: Английский

---

In situ 3D bioprinting with bioconcrete bioink

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: June 23, 2022

Abstract In-situ bioprinting is attractive for directly depositing the therapy bioink at defective organs to repair them, especially occupations such as soldiers, athletes, and drivers who can be injured in emergency. However, traditional displays obvious limitations its complex operation environments. Here, we design a bioconcrete with electrosprayed cell-laden microgels aggregate gelatin methacryloyl (GelMA) precursor solution cement. Promising printability guaranteed wide temperature range benefiting from robust rheological properties of photocrosslinked microgel fluidity GelMA Composite components simultaneously self-adapt biocompatibility different tissue mechanical microenvironment. Strong binding on tissue-hydrogel interface achieved by hydrogen bonds friction when cement photocrosslinked. This owns good portability easily prepared urgent accidents. Meanwhile, cultured mini tissues then mixed aggregates, indicating our functionalized faster than normal bioinks. The cranial defects results verify superiority this potential clinical settings required in-situ treatment.

Language: Английский

---

Fast, strong, and reversible adhesives with dynamic covalent bonds for potential use in wound dressing

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(29)

Published: July 13, 2022

Adhesives typically fall into two categories: those that have high but irreversible adhesion strength due to the formation of covalent bonds at interface and are slow deploy, others fast deploy is reversible weak in noncovalent bonds. Synergizing advantages from both categories remains challenging pivotal for development next generation wound dressing adhesives. Here, we report a adhesive consisting dynamic boronic ester bonds, formed between poly(vinyl alcohol) (PVA) boric acid (BA) potential use as adhesive. Mechanical testing shows film has shear 61 N/cm 2 transcutaneous 511 , generated within min application. Yet can be effortlessly debonded when exposed excess water. The mechanical properties PVA/BA adhesives tunable by varying cross-linking density. Within seconds activation water, surface undergo debonding instant softening, leading conformal contact with adherends reformation interface. Meanwhile, bulk dehydrated offer efficient load transmission, which important achieve strong without delamination Whether substrate smooth (e.g., glass) or rough hairy mouse skin), demonstrate superior compared most widely used topical skin clinical medicine, Dermabond.

Language: Английский

---

Wound management materials and technologies from bench to bedside and beyond

Nature Reviews Materials, Journal Year: 2024, Volume and Issue: 9(8), P. 550 - 566

Published: June 17, 2024

Language: Английский

---

Designing nanohesives for rapid, universal, and robust hydrogel adhesion

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Sept. 4, 2023

Abstract Nanoparticles-based glues have recently been shown with substantial potential for hydrogel adhesion. Nevertheless, the transformative advance in hydrogel-based application places great challenges on rapidity, robustness, and universality of achieving adhesion, which are rarely accommodated by existing nanoparticles-based glues. Herein, we design a type nanohesives based modulation mechanics surface chemical activation nanoparticles. The can form robust adhesion seconds, to arbitrary engineering solids biological tissues without any pre-treatments. A representative machine demonstrates tough compliant between dynamic sensors via nanohesives, guaranteeing accurate stable blood flow monitoring vivo. Combined their biocompatibility inherent antimicrobial properties, provide promising strategy field engineering.

Language: Английский

---

Bio‐Inspired Self‐Hydrophobized Sericin Adhesive with Tough Underwater Adhesion Enables Wound Healing and Fluid Leakage Sealing

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(32)

Published: May 17, 2022

Abstract Given that adhesion‐resistance of water severely weakens the bonding strength tissue adhesives, instant adhesion to wet biological surfaces remains challenging. Inspired by robust underwater natural creatures (such as mussels and barnacles whose derives from synergy hydrophobic adhesive matrix), a self‐hydrophobized is developed co‐assembly disulfide‐bond hydrolyzed sericin protein (a major component silkworm silk fibers) tannic acid. Once exposed water, self‐aggregation chains within repels enhances interfacial hydrogen or electrostatic interactions, mechanistically leading (>0.5 MPa for solid plates >0.1 tissues) durable (still maintained at 0.4 Mpa even after five cycles) adhesion. Owing its property, this possesses multiple advantages outperforming commercial such in vivo wound healing‐promoting effects, effective fluid leakage sealing, rapid hemostasis activity. This study not only offers novel strategy designing fabricating an with but also provides new various potential applications, including promoting healing hemostasis.

Language: Английский

---