Hemostatic patch with ultra-strengthened mechanical properties for efficient adhesion to wet surfaces DOI Creative Commons
Yuting Zheng, Kaavian Shariati, Mahsa Ghovvati

et al.

Biomaterials, Journal Year: 2023, Volume and Issue: 301, P. 122240 - 122240

Published: July 12, 2023

Controlling traumatic bleeding from damaged internal organs while effectively sealing the wound is critical for saving lives of patients. Existing bioadhesives suffer blood incompatibility, insufficient adhesion to wet surfaces, weak mechanical properties, and complex application procedures. Here, we engineered a ready-to-use hemostatic bioadhesive with ultra-strengthened properties fatigue resistance, robust tissues within few seconds gentle pressing, deformability accommodate physiological function action, ability stop efficiently. The hydrogel, which demonstrated high elasticity (>900%) toughness (>4600 kJ/m3), was formed by fine-tuning series molecular interactions crosslinking mechanisms involving N-hydroxysuccinimide (NHS) conjugated alginate (Alg-NHS), poly (ethylene glycol) diacrylate (PEGDA), tannic acid (TA), Fe3+ ions. Dual adhesive moieties including mussel-inspired pyrogallol/catechol NHS synergistically enhanced tissue (>400 kPa in closure test). In conjunction physical sealing, affinity TA/Fe3+ could further augment hemostasis. excellent vitro vivo biocompatibility as well improved efficacy compared commercial Surgicel®. Overall, hydrogel design strategy described herein holds great promise overcoming existing obstacles impeding clinical translation bioadhesives.

Language: Английский

Multiple Stimuli‐Responsive Nanozyme‐Based Cryogels with Controlled NO Release as Self‐Adaptive Wound Dressing for Infected Wound Healing DOI Open Access
Yutong Yang, Meng Li,

Guoying Pan

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(31)

Published: April 23, 2023

Abstract Wound with drug‐resistant bacterial infections has become a serious challenge for the healthcare system, and designing wound dressing to self‐adapt need of different stage healing remains challenging. Herein, self‐adaptive dressings multiple stimuli‐responsiveness antibacterial activity are developed. Specifically, MoS 2 carrying reactive oxygen species (ROS) responsive nitric oxide (NO) release precursor L‐arginine (MSPA) is designed incorporated into carboxymethyl chitosan/ poly( N‐isopropylacrylamide) based cryogels (CMCS/PNIPAM) responsiveness (pH, near infrared (NIR), temperature) form that adapt therapeutic needs stages in infected healing. In response slightly acidic environment infection, assist capture capacity through acid‐triggered protonation behavior, effectively enhance photodynamic efficiency. Controllable on‐demand delivery ROS, NO, remote management biofluid achieved NIR light as trigger switch. The stimuli‐responsive nanozyme‐based efficiently eliminate MRSA biofilm NO assisted photodynamicand photothermal therapy (PDT&PTT). enzyme‐like activities relieved oxidative damage. Notably, these reduce alleviated stress, accelerate collagen deposition angiogenesis wounds, indicating provide new ideas treatment.

Language: Английский

Citations

146
Highly efficient bacteria-infected diabetic wound healing employing a melanin-reinforced biopolymer hydrogel DOI

Yajing Xiang,

Xiaoliang Qi, Erya Cai

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 460, P. 141852 - 141852

Published: Feb. 11, 2023

Language: Английский

Citations

118
3D Printing of Microenvironment‐Specific Bioinspired and Exosome‐Reinforced Hydrogel Scaffolds for Efficient Cartilage and Subchondral Bone Regeneration DOI Creative Commons
Qi Li, Hui‐Lei Yu,

Fengyuan Zhao

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(26)

Published: July 9, 2023

Abstract In clinical practice, repairing osteochondral defects presents a challenge due to the varying biological properties of articular cartilages and subchondral bones. Thus, elucidating how spatial microenvironment‐specific biomimetic scaffolds can be used simultaneously regenerate tissue is an important research topic. Herein, novel bioinspired double‐network hydrogel scaffold produced via 3D printing with tissue‐specific decellularized extracellular matrix (dECM) human adipose mesenchymal stem cell (MSC)‐derived exosomes described. The bionic promote rat bone marrow MSC attachment, spread, migration, proliferation, chondrogenic osteogenic differentiation in vitro, as determined based on sustained release bioactive exosomes. Furthermore, 3D‐printed heterogeneous bilayer efficiently accelerate simultaneous regeneration cartilage tissues preclinical model. conclusion, dECM‐based biomimetics encapsulated serve cell‐free recipe for therapy when treating injured or degenerative joints. This strategy provides promising platform complex zonal whilst holding attractive translation potential.

Language: Английский

Citations

75
A Rapid Self‐Pumping Organohydrogel Dressing with Hydrophilic Fractal Microchannels to Promote Burn Wound Healing DOI
Jinze Lan,

Lianxin Shi,

Wuyi Xiao

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(38)

Published: June 15, 2023

Abstract Burn wounds pose great challenges for conventional dressings because massive exudates oversecreted from swollen tissues and blisters seriously delay wound healing. Herein, a self‐pumping organohydrogel dressing with hydrophilic fractal microchannels is reported that can rapidly drain excessive ≈30 times enhancement in efficiency compared the pure hydrogel, effectively promote burn A creaming‐assistant emulsion interfacial polymerization approach proposed to create hydrogel through dynamic floating‐colliding‐coalescing process of organogel precursor droplets. In murine model, rapid markedly reduce dermal cavity by ≈42.5%, accelerate blood vessel regeneration ≈6.6 times, hair follicle ≈13.5 commercial (Tegaderm). This study paves an avenue designing high‐performance functional dressings.

Language: Английский

Citations

67
Perspectives on recent advancements in energy harvesting, sensing and bio-medical applications of piezoelectric gels DOI Creative Commons
Thangavel Vijayakanth, Sudha Shankar, Gal Finkelstein-Zuta

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(17), P. 6191 - 6220

Published: Jan. 1, 2023

This review highlights the recent progress in piezoelectric gels (also known as PiezoGels) comprised of polymers, ceramic oxides and supramolecular materials used for energy harvesting, sensing wound dressing.

Language: Английский

Citations

67
Chitosan-based self-healing hydrogel dressing for wound healing DOI
Xingyu Zhang, Yongping Liang,

Shengfei Huang

et al.

Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 332, P. 103267 - 103267

Published: Aug. 3, 2024

Language: Английский

Citations

65
Gelable and Adhesive Powder for Lethal Non‐Compressible Hemorrhage Control DOI
Kaiwen Zhang,

Yiwen Xian,

Ming Li

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(46)

Published: Aug. 4, 2023

Abstract Hemostatic powders are widely used in clinical and emergency situations but often exhibit low wet adhesion, cytotoxicity concerns, do not work well for lethal non‐compressible hemorrhage. Here a new kind of gelable adhesive powder (GAP) is developed, which integrates chitosan microspheres (CM), tetra‐armed poly(ethylene glycol) amine (Tetra‐PEG‐NH 2 ), succinimidyl succinate (Tetra‐PEG‐SS). Upon application to the wound site, macroporous CM can rapidly absorb interfacial liquids, meanwhile, hydrated GAP turns into hydrogel (crosslinking between Tetra‐PEG‐SS CM/Tetra‐PEG‐NH ) with stable robust adhesion tissue though covalent bonding. The vitro vivo results suggest that optimized formulation exhibits strong adhesive, high burst pressure, enhanced blood clotting ability, as excellent biocompatibility on‐demand removal properties. A significantly improved hemostatic efficacy demonstrated rat liver, spleen, femoral artery injury models compared CM, commercial fibrin glue, Yunnan Baiyao (YB). also halt severe bleeding from pig visceral organs. Overall, proposed has many advantages including good biocompatibility, rapid effective hemostasis, cost, ease use, making it promising hemostat hemorrhage control.

Language: Английский

Citations

63
Designing self-healing hydrogels for biomedical applications DOI
Xiaoya Ding, Lu Fan, Li Wang

et al.

Materials Horizons, Journal Year: 2023, Volume and Issue: 10(10), P. 3929 - 3947

Published: Jan. 1, 2023

Self-healing hydrogels based on various dynamic interactions are comprehensively summarized and their biomedical applications also thoroughly elaborated.

Language: Английский

Citations

62
Chitosan-based hemostatic sponges as new generation hemostatic materials for uncontrolled bleeding emergency: Modification, composition, and applications DOI
Zhicheng Liu, Yanzi Xu, Huining Su

et al.

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 311, P. 120780 - 120780

Published: March 4, 2023

Language: Английский

Citations

57
Alginate-Based Electrospun Nanofibers and the Enabled Drug Controlled Release Profiles: A Review DOI Creative Commons
Zhiyuan Zhang, Hui Liu, Deng‐Guang Yu

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(7), P. 789 - 789

Published: July 3, 2024

Alginate is a natural polymer with good biocompatible properties and potential polymeric material for the sustainable development replacement of petroleum derivatives. However, non-spinnability pure alginate solutions has hindered expansion applications. With continuous electrospinning technology, synthetic polymers, such as PEO PVA, are used co-spinning agents to increase spinnability alginate. Moreover, coaxial, parallel Janus, tertiary other diverse novel electrospun fiber structures prepared by multi-fluid have found new breakthrough problem poor spinning polymers. Meanwhile, effectively achieve multiple release modes drugs. The powerful combination electrostatic widely in many biomedical fields, tissue engineering, regenerative bioscaffolds, drug delivery, research fever continues climb. This particularly true controlled delivery aspect review provides brief overview alginate, introduces advances spinning, highlights progress alginate-based nanofibers achieving various modes, pulsed release, sustained biphasic responsive targeted release.

Language: Английский

Citations

52