Research trends on cancer neuroscience: a bibliometric and visualized analysis DOI Creative Commons

Xinru Ma,

Kun Deng, Yingnan Sun

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Aug. 29, 2024

Background Recently, cancer neuroscience has become the focus for scientists. Interactions between nervous system and (both systemic local) can regulate tumorigenesis, progression, treatment resistance, compromise of anti-cancer immunity, provocation tumor-promoting inflammation. We assessed related research on through bibliometric analysis explored status hotspots from 2020 to 2024. Methods Publications retrieved Web Science Core Collection. CiteSpace, VOSviewer, Scimago Graphica were used analyze visualize result. Results A total 744 publications retrieved, with an upward trend in overall number articles published over last 5 years. As it highest ( n = 242) citations (average 13.63 per article), United States holds absolute voice field neuroscience. The most productive organizations journals Shanghai Jiaotong University 24) Cancers 45), respectively. Monje M (H-index 53), Hondermarck H 42), Amit 39) three researchers who have contributed field. From a global perspective, comprise nerve/neuron-tumor cell interactions, crosstalk other components tumor microenvironment (such as immune cells), well impact tumors therapies function. Conclusion European countries are dominating neuroscience, while developing such China growing rapidly but limited impact. next focal point this is likely be neurotrophic factors. Cancer still its infancy, which means that many interactions mechanisms not yet fully understood. Further investigation necessary probe subpopulations microenvironment.

Language: Английский

Metastasis DOI Creative Commons

Stefanie Gerstberger,

Qingwen Jiang, Karuna Ganesh

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(8), P. 1564 - 1579

Published: April 1, 2023

Language: Английский

Citations

369
Cancer neuroscience: State of the field, emerging directions DOI Creative Commons
Frank Winkler, Humsa S. Venkatesh, Moran Amit

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(8), P. 1689 - 1707

Published: April 1, 2023

The nervous system governs both ontogeny and oncology. Regulating organogenesis during development, maintaining homeostasis, promoting plasticity throughout life, the plays parallel roles in regulation of cancers. Foundational discoveries have elucidated direct paracrine electrochemical communication between neurons cancer cells, as well indirect interactions through neural effects on immune stromal cells tumor microenvironment a wide range malignancies. Nervous system-cancer can regulate oncogenesis, growth, invasion metastatic spread, treatment resistance, stimulation tumor-promoting inflammation, impairment anti-cancer immunity. Progress neuroscience may create an important new pillar therapy.

Language: Английский

Citations

213
Cancer hallmarks intersect with neuroscience in the tumor microenvironment DOI Creative Commons
Douglas Hanahan, Michelle Monje

Cancer Cell, Journal Year: 2023, Volume and Issue: 41(3), P. 573 - 580

Published: March 1, 2023

The mechanisms underlying the multistep process of tumorigenesis can be distilled into a logical framework involving acquisition functional capabilities, so-called hallmarks cancer, which are collectively envisaged to necessary for malignancy. These embodied both in transformed cancer cells as well heterotypic accessory that together constitute tumor microenvironment (TME), conveyed by certain abnormal characteristics cancerous phenotype. This perspective discusses link between nervous system and induction hallmark revealing neurons neuronal projections (axons) hallmark-inducing constituents TME. We also discuss autocrine paracrine regulatory circuits aberrantly activated may distinctive "enabling" characteristic contributing manifestation functions consequent pathogenesis.

Language: Английский

Citations

136
Crosstalk Between the Nervous System and Tumor Microenvironment: Functional Aspects and Potential Therapeutic Strategies DOI
Lei Wang, Jingjing Ge,

Huiqiong Han

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 594, P. 216986 - 216986

Published: May 24, 2024

Language: Английский

Citations

18
Organ-on-a-chip for dynamic tumor drug resistance investigation DOI
Changmin Shao, Yunru Yu, Xin Lei

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 460, P. 141739 - 141739

Published: Feb. 6, 2023

Language: Английский

Citations

24
Intrinsic and Microenvironmental Drivers of Glioblastoma Invasion DOI Open Access

Emerson De Fazio,

Matilde Pittarello,

Alessandro Gans

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2563 - 2563

Published: Feb. 22, 2024

Gliomas are diffusely infiltrating brain tumors whose prognosis is strongly influenced by their extent of invasion into the surrounding tissue. While lower-grade gliomas present more circumscribed borders, high-grade aggressive with widespread infiltration and dissemination. Glioblastoma (GBM) known for its high invasiveness association poor prognosis. Its low survival rate due to certainty recurrence, caused microscopic which makes surgical eradication unattainable. New insights GBM biology at single-cell level have enabled identification mechanisms exploited glioma cells invasion. In this review, we explore current understanding several molecular pathways used tumor invade normal We address intrinsic biological drivers cell invasion, tackling how interact each other microenvironment (TME). focus on recently discovered neuronal niche in TME, including local as well distant neurons, contributing growth then promoted astrocytes immune cells. Finally, review literature therapeutic targeting

Language: Английский

Citations

15
Sensory nerve release of CGRP increases tumor growth in HNSCC by suppressing TILs DOI Creative Commons
Laurel B. Darragh, Alexander Nguyen, Tiffany Pham

et al.

Med, Journal Year: 2024, Volume and Issue: 5(3), P. 254 - 270.e8

Published: Feb. 28, 2024

Language: Английский

Citations

11
Brain Tumor Networks in Diffuse Glioma DOI Creative Commons
Yvonne Yang, Marc C. Schubert, Thomas Kuner

et al.

Neurotherapeutics, Journal Year: 2022, Volume and Issue: 19(6), P. 1832 - 1843

Published: Oct. 1, 2022

Diffuse gliomas are primary brain tumors associated with a poor prognosis. Cellular and molecular mechanisms driving the invasive growth patterns therapeutic resistance incompletely understood. The emerging field of cancer neuroscience offers novel approach to study these in context their intricate interactions nervous system employing combining methodological toolsets from oncology. Increasing evidence has shown how neurodevelopmental neuronal-like hijacked leading discovery multicellular tumor networks. Here, we review gap junction-coupled tumor-tumor-astrocyte networks, as well synaptic paracrine neuron-tumor networks drive glioma progression. Molecular malignant, homo- heterotypic complex interplay reviewed. Lastly, potential clinical-translational implications resulting strategies discussed.

Language: Английский

Citations

26
Neurotransmitters: Impressive regulators of tumor progression DOI Open Access
Yumei Yang, Lei Sun,

Xuerou Liu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116844 - 116844

Published: May 31, 2024

In contemporary times, tumors have emerged as the primary cause of mortality in global population. Ongoing research has shed light on significance neurotransmitters regulation tumors. It been established that play a pivotal role tumor cell angiogenesis by triggering transformation stromal cells into cells, modulating receptors stem and even inducing immunosuppression. These actions ultimately foster proliferation metastasis cells. Several major found to exert modulatory effects including ability restrict emergency hematopoiesis bind postsynaptic membrane, thereby inhibiting malignant progression. The abnormal secretion is closely associated with progression, suggesting focusing may yield unexpected breakthroughs therapy. This article presents an analysis outlook potential targeting

Language: Английский

Citations

6
Tumor Neurobiology in the Pathogenesis and Therapy of Head and Neck Cancer DOI Creative Commons
Siyuan Liang, Jochen Heß

Cells, Journal Year: 2024, Volume and Issue: 13(3), P. 256 - 256

Published: Jan. 30, 2024

The neurobiology of tumors has attracted considerable interest from clinicians and scientists become a multidisciplinary area research. Neural components not only interact with tumor cells but also influence other elements within the TME, such as immune vascular components, forming polygonal relationship to synergistically facilitate growth progression. This review comprehensively summarizes current state knowledge on nerve-tumor crosstalk in head neck cancer discusses potential underlying mechanisms. Several mechanisms facilitating are covered, perineural invasion, axonogenesis, neurogenesis, neural reprogramming, transdifferentiation, reciprocal interactions between nervous systems TME discussed this review. Further understanding may provide new nerve-targeted treatment options help improve clinical outcomes for patients.

Language: Английский

Citations

5