Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(18), P. 10920 - 10989
Published: Sept. 15, 2023
Anticancer
nanomedicines
have
been
proven
effective
in
mitigating
the
side
effects
of
chemotherapeutic
drugs.
However,
challenges
remain
augmenting
their
therapeutic
efficacy.
Nanomedicines
responsive
to
pathological
abnormalities
tumor
microenvironment
(TME)
are
expected
overcome
biological
limitations
conventional
nanomedicines,
enhance
efficacies,
and
further
reduce
effects.
This
Review
aims
quantitate
various
TME,
which
may
serve
as
unique
endogenous
stimuli
for
design
stimuli-responsive
provide
a
broad
objective
perspective
on
current
understanding
cancer
treatment.
We
dissect
typical
transport
process
barriers
drug
delivery,
highlight
key
principles
designed
tackle
series
delivery
process,
discuss
"all-into-one"
"one-for-all"
strategies
integrating
needed
properties
nanomedicines.
Ultimately,
we
insight
into
future
perspectives
toward
clinical
translation
Journal of Hematology & Oncology,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: May 8, 2024
Abstract
Glioblastoma
(GBM),
the
predominant
and
primary
malignant
intracranial
tumor,
poses
a
formidable
challenge
due
to
its
immunosuppressive
microenvironment,
thereby
confounding
conventional
therapeutic
interventions.
Despite
established
treatment
regimen
comprising
surgical
intervention,
radiotherapy,
temozolomide
administration,
exploration
of
emerging
modalities
such
as
immunotherapy
integration
medicine
engineering
technology
therapy,
efficacy
these
approaches
remains
constrained,
resulting
in
suboptimal
prognostic
outcomes.
In
recent
years,
intensive
scrutiny
inhibitory
milieu
within
GBM
has
underscored
significance
cellular
constituents
microenvironment
their
interactions
with
cells
neurons.
Novel
immune
targeted
therapy
strategies
have
emerged,
offering
promising
avenues
for
advancing
treatment.
One
pivotal
mechanism
orchestrating
immunosuppression
involves
aggregation
myeloid-derived
suppressor
(MDSCs),
glioma-associated
macrophage/microglia
(GAM),
regulatory
T
(Tregs).
Among
these,
MDSCs,
though
constituting
minority
(4–8%)
CD45
+
GBM,
play
central
component
fostering
evasion
propelling
tumor
progression,
angiogenesis,
invasion,
metastasis.
MDSCs
deploy
intricate
mechanisms
that
adapt
dynamic
(TME).
Understanding
interplay
between
provides
compelling
basis
This
review
seeks
elucidate
inherent
explore
existing
targets,
consolidate
insights
into
MDSC
induction
contribution
immunosuppression.
Additionally,
comprehensively
surveys
ongoing
clinical
trials
potential
strategies,
envisioning
future
where
targeting
could
reshape
landscape
GBM.
Through
synergistic
other
modalities,
this
approach
can
establish
multidisciplinary,
multi-target
paradigm,
ultimately
improving
prognosis
quality
life
patients
Nature Medicine,
Journal Year:
2024,
Volume and Issue:
30(6), P. 1622 - 1635
Published: May 17, 2024
Abstract
Neural–tumor
interactions
drive
glioma
growth
as
evidenced
in
preclinical
models,
but
clinical
validation
is
limited.
We
present
an
epigenetically
defined
neural
signature
of
glioblastoma
that
independently
predicts
patients’
survival.
use
reference
signatures
cells
to
deconvolve
tumor
DNA
and
classify
samples
into
low-
or
high-neural
tumors.
High-neural
glioblastomas
exhibit
hypomethylated
CpG
sites
upregulation
genes
associated
with
synaptic
integration.
Single-cell
transcriptomic
analysis
reveals
a
high
abundance
malignant
stemcell-like
glioblastoma,
primarily
the
lineage.
These
are
further
classified
neural-progenitor-cell-like,
astrocyte-like
oligodendrocyte-progenitor-like,
alongside
oligodendrocytes
excitatory
neurons.
In
line
these
findings,
engender
neuron-to-glioma
synapse
formation
vitro
vivo
show
unfavorable
survival
after
xenografting.
patients,
decreased
overall
progression-free
tumors
also
increased
functional
connectivity
magnetencephalography
resting-state
magnet
resonance
imaging
can
be
detected
via
analytes
brain-derived
neurotrophic
factor
plasma.
The
prognostic
importance
was
validated
patients
diagnosed
diffuse
midline
glioma.
Our
study
presents
high-grade
gliomas
prognostically
relevant.
likely
require
maximized
surgical
resection
approach
for
improved
outcomes.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(6), P. 3167 - 3204
Published: Jan. 1, 2024
We
report
strategies
employed
by
metallacycle/metallacage-based
supramolecular
coordination
complexes
to
enhance
water
solubility
and
biostability
reduce
potential
toxicity
side
effects
for
biomedical
applications.
Cellular Oncology,
Journal Year:
2023,
Volume and Issue:
47(1), P. 1 - 17
Published: Aug. 23, 2023
Abstract
Background
In
recent
years,
the
significance
of
nervous
system
in
tumor
microenvironment
has
gained
increasing
attention.
The
bidirectional
communication
between
nerves
and
cancer
cells
plays
a
critical
role
initiation
progression.
Perineural
invasion
(PNI)
occurs
when
invade
nerve
sheath
and/or
encircle
more
than
33%
circumference.
PNI
is
common
feature
various
malignancies
associated
with
invasion,
metastasis,
cancer-related
pain,
unfavorable
clinical
outcomes.
colon
rectum
are
highly
innervated
organs,
accumulating
studies
support
as
histopathologic
colorectal
(CRC).
Therefore,
it
essential
to
investigate
CRC
comprehend
mechanisms
impede
progression
improve
patient
survival.
Conclusion
This
review
elucidates
PNI,
summarizes
underlying
cellular
molecular
mechanisms,
introduces
experimental
models
suitable
for
studying
discusses
therapeutic
potential
targeting
this
phenomenon.
By
delving
into
intricate
interactions
cells,
we
hope
can
provide
valuable
insights
future
development
treatments.
