ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(14), P. 12971 - 12999
Published: July 11, 2023
Swarms,
which
stem
from
collective
behaviors
among
individual
elements,
are
commonly
seen
in
nature.
Since
two
decades
ago,
scientists
have
been
attempting
to
understand
the
principles
of
natural
swarms
and
leverage
them
for
creating
artificial
swarms.
To
date,
underlying
physics;
techniques
actuation,
navigation,
control;
field-generation
systems;
a
research
community
now
place.
This
Review
reviews
fundamental
applications
micro/nanorobotic
The
generation
mechanisms
emergent
micro/nanoagents
identified
over
past
elucidated.
advantages
drawbacks
different
techniques,
existing
control
systems,
major
challenges,
potential
prospects
discussed.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: July 19, 2023
Various
nanoparticles
are
used
in
the
discovery
of
new
nanomedicine
to
overcome
shortages
conventional
drugs.
Therefore,
this
article
presents
a
comprehensive
and
up-to-date
review
effects
nanoparticle-based
drugs
treatment
respiratory
disorders,
including
both
basic
clinical
studies.
Databases,
PubMed,
Web
Knowledge,
Scopus,
were
searched
until
end
August
2022
regarding
effect
on
diseases.
As
tool,
offered
promising
applications
for
pulmonary
The
composition
intrinsic
characteristics
nanomaterials
showed
their
effectiveness
treating
efficiency
different
nanomedicines
has
been
demonstrated
experimental
animal
models
asthma,
chronic
obstructive
disease
(COPD),
fibrosis
(PF),
lung
cancer,
infection,
other
confirming
function
improvement
disorders.
types
nanomaterials,
such
as
carbon
nanotubes,
dendrimers,
polymeric
liposomes,
quantum
dots,
metal
oxide
nanoparticles,
have
therapeutic
which
may
lead
possible
remedies
various
illnesses
that
could
increase
drug
efficacy
decrease
side
effects.
Science Advances,
Journal Year:
2024,
Volume and Issue:
10(19)
Published: May 8, 2024
Lactic
acid
(LA)
accumulation
in
the
tumor
microenvironment
poses
notable
challenges
to
effective
immunotherapy.
Here,
an
intelligent
treatment
microrobot
based
on
unique
physiological
structure
and
metabolic
characteristics
of
Abstract
Micro/nanorobots
hold
exciting
prospects
for
biomedical
and
even
clinical
applications
due
to
their
small
size
high
controllability.
However,
it
is
still
a
big
challenge
maneuver
micro/nanorobots
into
narrow
spaces
with
deformability
adaptability
perform
complicated
tasks.
Here,
we
report
light-controlled
soft
bio-microrobots
(called
“Ebot”)
based
on
Euglena
gracilis
that
are
capable
of
performing
multiple
tasks
in
microenvironments
including
intestinal
mucosa
controllability,
adaptability.
The
motion
the
Ebot
can
be
precisely
navigated
via
polygonal
flagellum
beating.
Moreover,
shows
highly
controlled
different
light
illumination
duration,
which
allows
pass
through
curved
microchannels
With
these
features,
Ebots
able
execute
tasks,
such
as
targeted
drug
delivery,
selective
removal
diseased
cells
mucosa,
well
photodynamic
therapy.
This
provides
new
bio-microrobotic
tool,
many
possibilities
task
execution
where
conventional
tools
difficult
access
lack
bio-adaptability.
Science Robotics,
Journal Year:
2024,
Volume and Issue:
9(87)
Published: Feb. 21, 2024
Micro/nanorobotic
swarms
consisting
of
numerous
tiny
building
blocks
show
great
potential
in
biomedical
applications
because
their
collective
active
delivery
ability,
enhanced
imaging
contrast,
and
environment-adaptive
capability.
However,
vivo
real-time
tracking
micro/nanorobotic
remain
a
challenge,
considering
the
limited
size
spatial-temporal
resolution
current
modalities.
Here,
we
propose
strategy
that
enables
navigation
microswarm
stagnant
flowing
blood
environments
by
using
laser
speckle
contrast
(LSCI),
featuring
full-field
imaging,
high
temporal-spatial
resolution,
noninvasiveness.
The
change
dynamic
convection
induced
can
be
quantitatively
investigated
analyzing
perfusion
unit
(PU)
distribution,
offering
an
alternative
approach
to
investigate
swarm
behavior
its
interaction
with
various
environments.
Both
surrounding
environment
were
monitored
imaged
LSCI
real
time,
images
further
analyzed
for
simultaneous
complex
vascular
system.
Moreover,
our
realized
vivo,
showing
promising
LSCI-guided
Science Advances,
Journal Year:
2024,
Volume and Issue:
10(14)
Published: April 5, 2024
The
lack
of
bacterial-targeting
function
in
antibiotics
and
their
prophylactic
usage
have
caused
overuse
antibiotics,
which
lead
to
antibiotic
resistance
inevitable
long-term
toxicity.
To
overcome
these
issues,
we
develop
neutrophil-bacterial
hybrid
cell
membrane
vesicle
(HMV)–coated
biofunctional
lipid
nanoparticles
(LNP@HMVs),
are
designed
transport
specifically
bacterial
cells
at
the
infection
site
for
effective
treatment
prophylaxis
infection.
dual
targeting
ability
HMVs
inflammatory
vascular
endothelial
homologous
Gram-negative
results
targeted
accumulation
LNP@HMVs
infections.
loaded
with
norfloxacin
not
only
exhibit
enhanced
activity
against
planktonic
bacteria
biofilms
vitro
but
also
achieve
potent
therapeutic
efficacy
treating
both
systemic
lung
Furthermore,
trigger
activation
specific
humoral
cellular
immunity
prevent
Together,
provide
a
promising
strategy
effectively
treat
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(5), P. 2284 - 2299
Published: Jan. 1, 2024
A
biofilm
constitutes
a
bacterial
community
encased
in
sticky
matrix
of
extracellular
polymeric
substances.
These
intricate
microbial
communities
adhere
to
various
host
surfaces
such
as
hard
and
soft
tissues
well
indwelling
medical
devices.
aggregates
form
robust
substances
(EPSs),
leading
the
majority
human
infections.
Such
infections
tend
exhibit
high
resistance
treatment,
often
progressing
into
chronic
states.
The
EPS
protects
bacteria
from
hostile
environment
prevents
penetration
antibacterial
agents.
Modern
robots
at
nano,
micro,
millimeter
scales
are
highly
attractive
candidates
for
biomedical
applications
due
their
diverse
functionalities,
navigating
confined
spaces
targeted
multitasking.
In
this
tutorial
review,
we
describe
key
milestones
strategies
developed
removal
eradication
biofilms
using
different
sizes
shapes.
It
can
be
seen
that
useful
effective
tools
treating
biofilms,
thus
preventing
persistent
infections,
loss
costly
implanted
devices,
additional
costs
associated
with
hospitalization
therapies.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(4), P. 531 - 531
Published: April 12, 2024
Nanoparticle-based
drug
delivery
systems
hold
promise
for
cancer
treatment
by
enhancing
the
solubility
and
stability
of
anti-tumor
drugs.
Nonetheless,
challenges
inadequate
targeting
limited
biocompatibility
persist.
In
recent
years,
cell
membrane
nano-biomimetic
have
emerged
as
a
focal
point
research
development,
due
to
their
exceptional
traits,
including
precise
targeting,
low
toxicity,
good
biocompatibility.
This
review
outlines
categorization
advantages
bionic
nano-delivery
systems,
provides
an
introduction
preparation
methods,
assesses
applications
in
treatment,
chemotherapy,
gene
therapy,
immunotherapy,
photodynamic
photothermal
combination
therapy.
Notably,
delves
into
application
various
identifies
opportunities
future
advancement.
Embracing
membrane-coated
biomimetic
nanoparticles
presents
novel
unparalleled
avenue
personalized
tumor
Science Advances,
Journal Year:
2024,
Volume and Issue:
10(24)
Published: June 12, 2024
Lung
metastasis
poses
a
formidable
challenge
in
the
realm
of
cancer
treatment,
with
conventional
chemotherapy
often
falling
short
due
to
limited
targeting
and
low
accumulation
lungs.
Here,
we
show
microrobot
approach
using
motile
algae
for
localized
delivery
drug-loaded
nanoparticles
address
lung
challenges.
The
biohybrid
[denoted
“algae-NP(DOX)-robot”]
combines
green
microalgae
red
blood
cell
membrane–coated
containing
doxorubicin,
representative
chemotherapeutic
drug.
Microalgae
provide
autonomous
propulsion
lungs,
leveraging
controlled
drug
release
enhanced
dispersion
exert
antimetastatic
effects.
Upon
intratracheal
administration,
algae-NP(DOX)-robots
efficiently
transport
their
payload
deep
into
lungs
while
maintaining
continuous
motility.
This
strategy
leads
rapid
distribution,
improved
tissue
accumulation,
prolonged
retention
compared
passive
free
controls.
In
melanoma
model,
exhibit
substantial
improvement
therapeutic
efficacy,
reducing
metastatic
burden
extending
survival
control
groups.
