Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Dec. 17, 2022
Abstract
Methods
capable
of
manipulating
bacterial
colonization
are
great
significance
for
modulating
host-microbiota
relationships.
Here,
we
describe
a
strategy
in-situ
chemical
reaction-mediated
covalent
localization
bacteria.
Through
simple
one-step
imidoester
reaction,
primary
amino
groups
on
surface
can
be
converted
to
free
thiols
under
cytocompatible
conditions.
Surface
thiolation
is
applicable
modify
diverse
strains
and
the
number
introduced
per
bacterium
easily
tuned
by
varying
feed
ratios.
These
chemically
reactive
bacteria
able
spontaneously
bond
with
mucous
layer
catalyst-free
thiol-disulfide
exchange
between
mucin-associated
disulfides
newly
show
level-dependent
attachment.
Bacteria
optimized
9.3
×
10
7
cell
achieve
170-fold
higher
attachment
in
mucin-enriched
jejunum,
challenging
location
gut
microbiota
colonize.
As
proof-of-concept
application
transplantation,
bonding-assisted
an
oral
probiotic
jejunum
generates
improved
remission
jejunal
mucositis.
Our
findings
demonstrate
that
transforming
provides
approach
control
localization,
which
highly
desirable
developing
next-generation
living
bioagents.
Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(9), P. 3324 - 3340
Published: Jan. 1, 2022
This
tutorial
review
highlights
the
concept
and
significance
of
antibacterial
phototherapy.
Recent
developments,
advantages,
challenges
organic
photosensitizers
in
this
area
are
also
discussed.
Antibiotics,
Journal Year:
2021,
Volume and Issue:
10(12), P. 1473 - 1473
Published: Nov. 30, 2021
The
emergence
of
infectious
diseases
promises
to
be
one
the
leading
mortality
factors
in
healthcare
sector.
Although
several
drugs
are
available
on
market,
newly
found
microorganisms
carrying
multidrug
resistance
(MDR)
against
which
existing
cannot
function
effectively,
giving
rise
escalated
antibiotic
dosage
therapies
and
need
develop
novel
drugs,
require
time,
money,
manpower.
Thus,
exploitation
antimicrobials
has
led
production
MDR
bacteria,
their
prevalence
growth
a
major
concern.
Novel
approaches
prevent
antimicrobial
drug
practice.
Nanotechnology-based
innovation
provides
physicians
patients
opportunity
overcome
crisis
resistance.
Nanoparticles
have
promising
potential
Recently,
nanoparticles
been
designed
address
pathogenic
microorganisms.
A
multitude
processes
that
can
vary
with
various
traits,
including
size,
morphology,
electrical
charge,
surface
coatings,
allow
researchers
composite
substances
for
use
different
applications
performing
activities.
activity
inorganic
carbon-based
applied
research,
medical,
industrial
uses
future
offer
solution
traditional
approaches.
Metal-based
also
extensively
studied
many
biomedical
applications.
In
addition
reduced
size
selectivity
metal-based
proven
effective
pathogens
listed
as
priority,
according
World
Health
Organization
(WHO).
Moreover,
studies
were
carried
out
not
only
vitro
but
vivo
well
order
investigate
efficacy.
addition,
nanomaterials
provide
numerous
opportunities
infection
prevention,
diagnosis,
treatment,
biofilm
control.
This
study
emphasizes
effects
contrasts
nanoparticles’
antibiotics’
role
fight
Future
prospects
revolve
around
developing
new
strategies
products
prevent,
control,
treat
microbial
infections
humans
other
animals,
viral
seen
current
pandemic
scenarios.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Feb. 21, 2024
Abstract
Inflammation-associated
diseases
encompass
a
range
of
infectious
and
non-infectious
inflammatory
diseases,
which
continuously
pose
one
the
most
serious
threats
to
human
health,
attributed
factors
such
as
emergence
new
pathogens,
increasing
drug
resistance,
changes
in
living
environments
lifestyles,
aging
population.
Despite
rapid
advancements
mechanistic
research
development
for
these
current
treatments
often
have
limited
efficacy
notable
side
effects,
necessitating
more
effective
targeted
anti-inflammatory
therapies.
In
recent
years,
nanotechnology
has
provided
crucial
technological
support
prevention,
treatment,
detection
inflammation-associated
diseases.
Various
types
nanoparticles
(NPs)
play
significant
roles,
serving
vaccine
vehicles
enhance
immunogenicity
carriers
improve
targeting
bioavailability.
NPs
can
also
directly
combat
pathogens
inflammation.
addition,
facilitated
biosensors
pathogen
imaging
techniques
This
review
categorizes
characterizes
different
NPs,
summarizes
their
applications
It
discusses
challenges
associated
with
clinical
translation
this
field
explores
latest
developments
prospects.
conclusion,
opens
up
possibilities
comprehensive
management
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(11), P. 17080 - 17123
Published: Oct. 26, 2021
Cell
membrane-coated
(CMC)
mimics
are
micro/nanosystems
that
combine
an
isolated
cell
membrane
and
a
template
of
choice
to
mimic
the
functions
cell.
The
design
exploits
its
physicochemical
biological
properties
for
therapeutic
applications.
demonstrate
excellent
compatibility,
enhanced
biointerfacing
capabilities,
physical,
chemical,
tunability,
ability
retain
cellular
properties,
immune
escape,
prolonged
circulation
time,
protect
encapsulated
drug
from
degradation
active
targeting.
These
ease
adapting
them
personalized
clinical
medicine
have
generated
significant
research
interest
over
past
decade.
This
review
presents
detailed
overview
recent
advances
in
development
mimics.
primary
focus
is
collate
discuss
components,
fabrication
methodologies,
significance
physiochemical
characterization
techniques
validating
CMC
mimic.
We
present
critical
analysis
two
main
components
mimics:
mapped
their
use
scenarios.
In
addition,
we
emphasized
on
challenges
associated
with
translation.
Overall,
this
up
date
toolbox
researchers
can
benefit
while
designing
characterizing
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
34(2)
Published: Oct. 5, 2021
Abstract
Synthetic
polymers
are
omnipresent
in
society
as
textiles
and
packaging
materials,
construction
medicine,
among
many
other
important
applications.
Alternatively,
natural
play
a
crucial
role
sustaining
life
allowing
organisms
to
adapt
their
environments
by
performing
key
biological
functions
such
molecular
recognition
transmission
of
genetic
information.
In
general,
the
synthetic
polymer
worlds
completely
separated
due
inability
for
perform
specific
functions;
some
cases,
cause
uncontrolled
unwanted
responses.
However,
owing
advancement
polymerization
techniques
recent
years,
new
have
emerged
that
provide
targeted
peptides,
or
present
antiviral,
anticancer,
antimicrobial
activities.
this
review,
emergence
generation
bioactive
bioapplications
summarized.
Finally,
future
opportunities
area
discussed.
Acta Pharmaceutica Sinica B,
Journal Year:
2022,
Volume and Issue:
12(5), P. 2206 - 2223
Published: Jan. 4, 2022
Looking
retrospectively
at
the
development
of
humanity,
vaccination
is
an
unprecedented
medical
landmark
that
saves
lives
by
harnessing
human
immune
system.
During
ongoing
coronavirus
disease
2019
(COVID-19)
pandemic,
still
most
effective
defense
modality.
The
successful
clinical
application
lipid
nanoparticle-based
Pfizer/BioNTech
and
Moderna
mRNA
COVID-19
vaccines
highlights
promising
future
nanotechnology
in
vaccine
development.
Compared
with
conventional
vaccines,
nanovaccines
are
supposed
to
have
advantages
lymph
node
accumulation,
antigen
assembly,
presentation;
they
also
have,
unique
pathogen
biomimicry
properties
because
well-organized
combination
multiple
factors.
Beyond
infectious
diseases,
exhibits
considerable
potential
for
cancer
treatment.
ultimate
goal
fully
mobilize
potency
system
as
a
living
therapeutic
recognize
tumor
antigens
eliminate
cells,
nanotechnologies
requisite
realize
this
goal.
In
review,
we
summarize
recent
advances
from
prevention
immunotherapy
highlight
different
types
materials,
mechanisms,
administration
methods,
well
perspectives.
