Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
177, P. 116951 - 116951
Published: June 19, 2024
The
emerging
strategy
of
biomimetic
nanoparticles
(NPs)
via
cellular
membrane
camouflage
holds
great
promise
in
cancer
therapy.
This
scholarly
review
explores
the
utilization
membranes
derived
from
diverse
entities;
blood
cells,
immune
stem
and
bacterial
cells
as
examples
NP
coatings.
camouflaging
endows
NPs
with
nuanced
tumor-targeting
abilities
such
self-recognition,
homotypic
targeting,
long-lasting
circulation,
thus
also
improving
tumor
therapy
efficacy
overall.
comprehensive
examination
encompasses
a
variety
cell
camouflaged
(CMCNPs),
elucidating
their
underlying
targeted
mechanisms
delineating
strategies
for
anti-cancer
applications.
Furthermore,
systematically
presents
synthesis
source
materials
methodologies
employed
order
to
construct
characterize
these
CMCNPs,
specific
emphasis
on
use
treatment.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(7), P. 9994 - 10041
Published: June 22, 2022
Worldwide
nanotechnology
development
and
application
have
fueled
many
scientific
advances,
but
technophilic
expectations
technophobic
demands
must
be
counterbalanced
in
parallel.
Some
of
the
burning
issues
today
are
following:
(1)
Where
is
nano
today?
(2)
How
good
communication
investment
networks
between
academia/research
governments?
(3)
Is
there
any
spotlight
for
nanotechnology?
Nanomedicine
a
particular
arm
within
healthcare
landscape,
focused
on
diagnosis,
treatment,
monitoring
emerging
(such
as
coronavirus
disease
2019,
COVID-19)
contemporary
(including
diabetes,
cardiovascular
diseases,
neurodegenerative
disorders,
cancer)
diseases.
However,
it
may
only
represent
bright
side
coin.
In
fact,
recent
past,
concept
nanotoxicology
has
emerged
to
address
dark
shadows
nanomedicine.
The
nanomedicine
field
requires
more
nanotoxicological
studies
identify
undesirable
effects
guarantee
safety.
Here,
we
provide
an
overall
perspective
central
pieces
giant
puzzle
nanotechnology.
First,
impact
education
research
highlighted,
followed
by
market
trends
output
tendencies.
next
section,
dilemma
addressed
through
interplay
silico,
vitro,
vivo
models
with
support
omics
microfluidic
approaches.
Lastly,
reflection
regulatory
clinical
trials
provided.
Finally,
some
conclusions
future
perspectives
proposed
clearer
safer
translation
nanomedicines
from
bench
bedside.
Biomaterials Science,
Journal Year:
2022,
Volume and Issue:
10(5), P. 1193 - 1208
Published: Jan. 1, 2022
Macrophage
membrane
coated
nanomaterials
are
used
in
various
therapies,
against
infections
and
inflammation
order
to
combat
immune
barriers
without
compromising
the
efficacy
of
“cargo”
molecules.
Journal of Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: Jan. 21, 2022
Abstract
Background
Inspired
by
nature,
the
biomimetic
approach
has
been
incorporated
into
drug
nanocarriers
for
cancer
targeted
chemotherapy.
The
are
cloaked
in
cell
membranes,
which
enables
them
to
incorporate
functions
of
natural
cells.
Key
scientific
concepts
review
Nanocarriers
surface
engineered
with
membranes
have
emerged
as
a
fascinating
source
materials
A
distinctive
characteristic
membrane-coated
(CMCNs)
is
that
they
include
carbohydrates,
proteins,
and
lipids,
addition
being
biocompatible.
CMCNs
capable
interacting
complicated
biological
milieu
tumor
because
contain
signaling
networks
intrinsic
their
parent
Numerous
investigated
purpose
masking
various
tumor-targeting
methods
devised
improve
Moreover,
diverse
structure
membrane
from
different
sources
broadens
spectrum
offers
an
entirely
new
class
drug-delivery
systems.
Aim
This
will
describe
manufacturing
processes
therapeutic
uses
kinds
nanocarrier-based
delivery
systems,
well
addressing
obstacles
future
prospects.
Graphical
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
34(30)
Published: June 7, 2022
Osteoarthritis
(OA)
is
a
low-grade
inflammatory
and
progressive
joint
disease,
its
progression
closely
associated
with
an
imbalance
in
M1/M2
synovial
macrophages.
Repolarizing
pro-inflammatory
M1
macrophages
into
the
anti-inflammatory
M2
phenotype
emerging
as
strategy
to
alleviate
OA
but
compromised
by
unsatisfactory
efficiency.
In
this
study,
reprogramming
of
mitochondrial
dysfunction
pioneered
camouflaged
meta-Defensome,
which
can
transform
high
efficiency
82.3%.
The
meta-Defensome
recognizes
activated
via
receptor-ligand
interactions
accumulates
mitochondria
through
electrostatic
attractions.
These
meta-Defensomes
are
macrophage-membrane-coated
polymeric
nanoparticles
decorated
dual
ligands
co-loaded
S-methylisothiourea
MnO2
.
Meta-Defensomes
demonstrated
successfully
reprogram
metabolism
scavenging
reactive
oxygen
species
inhibiting
NO
synthase,
thereby
increasing
transcription
factor
A
expression
restoring
aerobic
respiration.
Furthermore,
intravenously
injected
collagenase-induced
osteoarthritis
mice
effectively
suppress
inflammation
early
OA,
evident
from
Research
Society
International
score.
Therefore,
serve
novel
practical
approach
repolarize
promising
therapeutic
agent
for
impeding
tclinic.
Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
20, P. 100633 - 100633
Published: April 12, 2023
With
the
development
of
nanotechnology,
nanoparticles
have
emerged
as
a
delivery
carrier
for
tumor
drug
therapy,
which
can
improve
therapeutic
effect
by
increasing
stability
and
solubility
prolonging
half-life
drugs.
However,
are
foreign
substances
humans,
easily
cleared
immune
system,
less
targeted
to
tumors,
may
even
be
toxic
body.
As
natural
biological
material,
cell
membranes
unique
properties,
such
good
biocompatibility,
strong
targeting
ability,
ability
evade
surveillance,
high
drug-carrying
capacity.
In
this
article,
we
review
membrane-coated
(CMNPs)
their
applications
therapy.
First,
briefly
describe
CMNP
characteristics
applications.
Second,
present
advantages
different
well
nanoparticles,
provide
brief
description
process
CMNPs,
discuss
current
status
application
summarize
shortcomings
use
in
cancer
propose
future
research
directions.
This
summarizes
progress
on
CMNPs
therapy
recent
years
assesses
remaining
problems,
providing
scholars
with
new
ideas
Small,
Journal Year:
2024,
Volume and Issue:
20(35)
Published: May 1, 2024
Abstract
Cancer
nanovaccines
represent
a
promising
frontier
in
cancer
immunotherapy,
utilizing
nanotechnology
to
augment
traditional
vaccine
efficacy.
This
review
comprehensively
examines
the
current
state‐of‐the‐art
nanovaccine
development,
elucidating
innovative
strategies
and
technologies
employed
their
design.
It
explores
both
preclinical
clinical
advancements,
emphasizing
key
studies
demonstrating
potential
elicit
robust
anti‐tumor
immune
responses.
The
study
encompasses
various
facets,
including
integrating
biomaterial‐based
nanocarriers
for
antigen
delivery,
adjuvant
selection,
impact
of
nanoscale
properties
on
performance.
Detailed
insights
into
complex
interplay
between
tumor
microenvironment
responses
are
provided,
highlighting
challenges
opportunities
optimizing
therapeutic
outcomes.
Additionally,
presents
thorough
analysis
ongoing
trials,
presenting
snapshot
landscape.
By
curating
latest
scientific
findings
developments,
this
aims
serve
as
comprehensive
resource
researchers
clinicians
engaged
advancing
immunotherapy.
Integrating
design
holds
immense
promise
revolutionizing
treatment
paradigms,
provides
timely
update
evolving
landscape
nanovaccines.
