Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 259, P. 155346 - 155346
Published: May 11, 2024
Language: Английский
Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 5, 2024
Language: Английский
Citations
10
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 7033 - 7048
Published: July 1, 2024
Purpose: The anticancer potential of indomethacin and other nonsteroidal anti-inflammatory drugs (NSAIDs) in vitro, vivo, clinical trials is well known widely reported the literature, along with their side effects, which are mainly observed gastrointestinal tract. Here, we present a strategy for application old drug as an agent by encapsulating it nanostructured lipid carriers (NLC). We describe production method IND-NLC, physicochemical parameters, results antiproliferative activity against selected cancer cell lines, were found to be higher compared free indomethacin. Methods: IND-NLC fabricated using hot high-pressure homogenization method. nanocarriers physicochemically characterized, biopharmaceutical behaviour therapeutic efficacy evaluated vitro. Results: Lipid nanoparticles exhibited particle size 168.1 nm, negative surface charge (– 30.1 mV), low polydispersity index (PDI 0.139), high encapsulation efficiency (over 99%). stable over 60 days retained integrity during storage at 4 °C 25 °C. benefits screened vitro models, where encapsulated effectively inhibited growth breast line MDA-MB-468 dosage 15.7 μM. Conclusion: successfully developed delivery cells confirmed antitumoral studies. suggest that possesses potential. Moreover, presented highly promising may offer new alternative future innovations. Keywords: nanoparticles, indomethacin, activity, tumor-targeting
Language: Английский
Citations
8
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 191 - 201
Published: Jan. 10, 2025
Skin and soft tissue infections (SSTI) include bacterial of the skin, muscles, connective such as ligaments tendons. SSTI in patients with immunocompromising diseases may lead to chronic, hard-to-heal infected wounds, resulting disability, amputation, or even death. To treat rebuild defensive barrier here we utilize recombinant type XVII collagen protein (rCol XVII) construct biodegradable, regenerative microneedles (rCol-MNs) for transdermal delivery antibacterial agents. Spheroidal copper-DNA nanoparticles (Cu-CpG NPs; CpG represents short single-stranded synthetic DNA molecules cytosine guanine) are synthesized copper ions oligodeoxynucleotides (ODNs), followed by polydopamine (PDA) coating obtain Cu-CpG@PDA. Doping Cu-CpG@PDA into rCol-MNs yields Cu-CpG@PDA-loaded rCol-MNs. These combine photothermal conversion property PDA, properties ions, innate immune activation ODNs, skin regenerating ability rCol XVII, allowing treatment also damaged skin. In a mouse model, show that rescue wound infections, facilitate orderly deposition at site, promote healing full-thickness wounds without noticeable scar formation. serve vehicle and, simultaneously, reservoir skin-regenerating collagen, bringing combined benefits infection control regeneration. SIGNIFICANCE STATEMENT: Treatment requires agents dermis while providing environment open wounds. Here, devise meet both requirements.
Language: Английский
Citations
1
Materials Science and Engineering R Reports, Journal Year: 2025, Volume and Issue: 163, P. 100929 - 100929
Published: Jan. 18, 2025
Language: Английский
Citations
1
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 27, 2025
How to accurately diagnose and treat bacterial infections in vivo remains a huge challenge. Therefore, we have developed targeted delivery nanosystem by coextruding the pretreated macrophage membrane of S. aureus with carbon dots (M@CD). The M@CD demonstrates potent antibacterial effects both vitro through generation reactive oxygen species (ROS). Furthermore, exhibits enhanced targeting ability stable fluorescence properties, addressing issues such as poor efficiency high immunogenicity vivo. This innovative approach enables infection site specific aggregation elimination infections, thereby providing promising strategy for integrated diagnosis, treatment, monitoring infections.
Language: Английский
Citations
1
ACS Omega, Journal Year: 2025, Volume and Issue: 10(7), P. 6679 - 6688
Published: Feb. 11, 2025
The antimicrobial resistance of Mycobacterium tuberculosis (M. tuberculosis) is a challenge in the antibiotic treatment (TB). Herein, we aimed to examine photodynamic therapy for TB that has low risk drug and involves biomimetic macrophage membranes combined with photosensitizer, chlorin e6 (Ce6; hereinafter, C-MV). We used marinum marinum), waterborne pathogen closely related M. tuberculosis, which causes TB-like infections ectotherms but not humans. mouse tail granuloma model induced by relatively mature developed our team. C-MV nanoparticles were prepared injected intravenously, showing longevity circulation due properties membrane, protects them from being eliminated blood. They then guided tuberculous granulomas, helping deliver precise therapy. Ce6 classical photosensitizer triggers production reactive oxygen species under laser irradiation, causing death. showed good compatibility long time, effectively inhibiting proliferation infiltration marinum, providing new paradigm treatment.
Language: Английский
Citations
1
Alexandria Engineering Journal, Journal Year: 2024, Volume and Issue: 98, P. 328 - 343
Published: May 7, 2024
In the field of medical imaging, increasing demand for advanced computer-aided diagnosis systems is crucial in radiography. Accurate identification various diseases, such as COVID-19, pneumonia, tuberculosis, and pulmonary lung nodules, holds vital significance. Despite substantial progress field, a persistent research gap necessitates development models that excel precision provide transparency decision-making processes. order to address this issue, work introduces an approach utilizes transfer learning through EfficientNet-B4 architecture, leveraging pre-trained model enhance classification performance on comprehensive dataset X-rays. The integration explainable artificial intelligence (XAI), specifically emphasizing Grad-CAM, contributes interpretability by providing insights into neural network's process, elucidating salient features activation regions influencing multi-disease classifications. result robust system achieving impressive 96% accuracy, accompanied visualizations highlighting critical X-ray images. This investigation not only advances progression but also sets pioneering benchmark dependable transparent diagnostic disease identification.
Language: Английский
Citations
8
PubMed, Journal Year: 2024, Volume and Issue: 23, P. 570 - 599
Published: Jan. 1, 2024
Cancer poses intricate challenges to treatment due its complexity and diversity. Ferroptosis circular RNAs (circRNAs) are emerging as innovative therapeutic avenues amid the evolving landscape of cancer therapy. Extensive investigations into circRNAs reveal their diverse roles, ranging from molecular regulators pivotal influencers ferroptosis in cell lines. The results underscore significance modulating pathways that impact crucial aspects development, including survival, proliferation, metastasis. A detailed analysis delineates these pathways, shedding light on mechanisms through which influence ferroptosis. Building upon recent experimental findings, study evaluates potential targeting induce By identifying specific associated with etiology cancer, this paves way for development targeted therapeutics exploit vulnerabilities cells. This review consolidates existing understanding circRNAs, emphasizing role therapy providing impetus ongoing research dynamic field. See also graphical abstract(Fig. 1).
Language: Английский
Citations
7
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(29)
Published: June 25, 2024
Emerging infectious diseases like coronavirus pneumonia (COVID-19) present significant challenges to global health, extensively affecting both human society and the economy. Extracellular vesicles (EVs) have demonstrated remarkable potential as crucial biomedical tools for COVID-19 diagnosis treatment. However, due limitations in performance titer of natural vesicles, their clinical use remains limited. Nonetheless, EV-inspired strategies are gaining increasing attention. Notably, biomimetic inspired by EVs, possess specific receptors that can act "Trojan horses," preventing virus from infecting host cells. Genetic engineering enhance these enabling them carry more receptors, significantly specificity absorbing novel coronavirus. Additionally, inherit numerous cytokine parent cells, allowing effectively mitigate "cytokine storm" adsorbing pro-inflammatory cytokines. Overall, this strategy offers new avenues treatment emerging diseases. Herein, review systematically summarizes current applications COVID-19. The status associated with implementation also discussed. goal is provide insights into design expand application combating
Language: Английский
Citations
7
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(32), P. 41916 - 41926
Published: July 31, 2024
Photosensitizer-based phototherapies, including photodynamic therapy (PDT) and photothermal (PTT), offer safe treatment modalities for tumor ablation with spatiotemporal precision. After photons are absorbed, PDT creates localized chemical damage by generating reactive oxygen species (ROS), while PTT induces thermal damage. However, still faces hypoxic challenges, encounters issues related to heat resistance potential overheating. The combination of shows great as an effective anticancer strategy. By targeting lysosomes carefully designed phototherapeutic reagents combined phototherapy, rapid dysfunction cell death in cancer cells can be induced, showing promise treatment. Herein, two α–α-linked bisBODIPYs tetraphenylethene (TPE) moieties synthesized. These TPE-substituted expand the absorption into NIR range (λmaxabs/λmaxem ∼ 740/810 nm) confer aggregation-induced emission (AIE) activity (λmaxem 912 nm). Moreover, these self-assemble surfactant F-127 nanoparticles (NPs), which efficiently generate ROS (1O2 •OH) both solution cellular environments demonstrate superior conversion efficiencies (η 68.3%) along exceptional stability. More importantly, NPs showed lysosomal remarkable murine models, indicating their precision therapy.
Language: Английский
Citations
6