International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(9), P. 4832 - 4832
Published: April 29, 2024
This
review
offers
a
comprehensive
exploration
of
the
intricate
immunological
landscape
breast
cancer
(BC),
focusing
on
recent
advances
in
diagnosis
and
prognosis
through
analysis
circulating
tumor
cells
(CTCs).
Positioned
within
broader
context
BC
research,
it
underscores
pivotal
role
immune
system
shaping
disease’s
progression.
The
primary
objective
this
investigation
is
to
synthesize
current
knowledge
aspects
BC,
with
particular
emphasis
diagnostic
prognostic
potential
offered
by
CTCs.
adopts
thorough
examination
relevant
literature,
incorporating
breakthroughs
field.
methodology
section
succinctly
outlines
approach,
specific
focus
CTC
its
implications
for
prognosis.
Through
review,
insights
into
dynamic
interplay
between
are
highlighted,
CTCs
advancing
methodologies
refining
assessments.
Furthermore,
presents
substantiated
results,
contributing
deeper
understanding
complexity
BC.
In
conclusion,
significance
exploring
profile
patients,
providing
valuable
novel
utilization
presentation
findings
emphasizes
crucial
dynamics,
thereby
opening
avenues
enhanced
clinical
management
strategies.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
163, P. 114758 - 114758
Published: May 2, 2023
Treatment
of
metastatic
cancer
is
one
the
biggest
challenges
in
anticancer
therapy.
Curcumin
interesting
nature
polyphenolic
compound
with
unique
biological
and
medicinal
effects,
including
repression
metastases.
High
impact
studies
imply
that
curcumin
can
modulate
immune
system,
independently
target
various
signalling
pathways,
repress
migration
invasiveness
cells.
This
review
discusses
potential
as
an
antimetastatic
agent
describes
mechanisms
its
activity.
In
addition,
possible
strategies
(curcumin
formulation,
optimization
method
administration
modification
structure
motif)
to
overcome
limitation
such
low
solubility
bioactivity
are
also
presented.
These
discussed
context
clinical
trials
relevant
studies.
Aging and Disease,
Journal Year:
2024,
Volume and Issue:
unknown, P. 0 - 0
Published: Jan. 1, 2024
Metabolic
reprogramming
is
a
defining
hallmark
of
cancer
metastasis,
warranting
thorough
exploration.
The
tumor-promoting
function
the
"Warburg
Effect",
marked
by
escalated
glycolysis
and
restrained
mitochondrial
activity,
widely
acknowledged.
Yet,
functional
significance
mitochondria-mediated
oxidative
phosphorylation
(OXPHOS)
during
metastasis
remains
controversial.
Circulating
tumor
cells
(CTCs)
are
considered
metastatic
precursors
that
detach
from
primary
or
secondary
sites
harbor
potential
to
seed
distant
metastases
through
hematogenous
dissemination.
A
comprehensive
metabolic
characterization
CTCs
faces
formidable
obstacles,
including
isolation
these
rare
billions
blood
cells,
coupled
with
complexities
ex
vivo-culturing
CTC
lines
establishment
CTC-derived
xenograft
models
(CDX).
This
review
summarized
role
Effect"
in
both
tumorigenesis
CTC-mediated
metastasis.
Intriguingly,
bioinformatic
analysis
single-CTC
transcriptomic
studies
unveils
OXPHOS
dominance
over
Glycolysis
signature
genes
across
several
important
types.
From
observations,
we
postulate
"Anti-Warburg
(AWE)
CTCs—a
shift
bridging
tumors
metastases.
observed
AWE
could
be
clinically
as
they
significantly
correlated
therapeutic
response
melanoma
prostate
patients.
Thus,
unraveling
dynamic
regulations
within
populations
might
reveal
an
additional
layer
regulatory
providing
avenue
for
innovative
anti-metastasis
therapies.
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Feb. 8, 2024
Extravasation
is
a
fundamental
step
in
the
metastatic
journey,
where
cancer
cells
exit
bloodstream
and
breach
endothelial
cell
barrier
to
infiltrate
target
tissues.
The
tactics
employ
are
sophisticated,
closely
reflecting
those
used
by
immune
system
for
tissue
surveillance.
Remarkably,
tumor
have
been
observed
form
distinct
associations
or
clusters
with
neutrophils
stand
out
as
particularly
crucial
partners.
These
interactions
not
accidental;
they
critical
exploit
functions
of
successfully
extravasate.
In
another
strategy,
mimic
behavior
characteristics
cells.
They
release
suite
inflammatory
mediators,
which
under
normal
circumstances,
guide
processes
endothelium
reshaping
facilitate
entry
movement
within
this
review,
we
offer
new
perspective
on
employed
extravasate
We
delve
into
myriad
mechanisms
that
borrow,
adapt,
refine
from
playbook.
Video
Abstract.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(21)
Published: Jan. 15, 2024
Microfluidic
chips
are
valuable
tools
for
studying
intricate
cellular
and
cell-microenvironment
interactions.
Traditional
in
vitro
cancer
models
lack
accuracy
mimicking
the
complexities
of
vivo
tumor
microenvironment.
However,
cancer-metastasis-on-a-chip
(CMoC)
combine
advantages
3D
cultures
microfluidic
technology,
serving
as
powerful
platforms
exploring
mechanisms
facilitating
drug
screening.
These
able
to
compartmentalize
metastatic
cascade,
deepening
understanding
its
underlying
mechanisms.
This
article
provides
an
overview
current
CMoC
models,
focusing
on
distinctive
that
simulate
invasion,
intravasation,
circulation,
extravasation,
colonization,
their
applications
Furthermore,
challenges
faced
by
technologies
discussed,
while
promising
future
directions
research.
The
ongoing
development
integration
these
into
studies
expected
drive
transformative
advancements
field.
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
32(1), P. 200762 - 200762
Published: Jan. 21, 2024
Circulating
tumor
cells
(CTCs)
are
the
seeds
of
distant
metastases
malignant
tumors
and
associated
with
malignancy
risk
metastasis.
However,
undergo
epithelial-mesenchymal
transition
(EMT)
during
metastasis,
leading
to
emergence
different
types
CTCs.
Real-time
dynamic
molecular
functional
typing
CTCs
is
necessary
precisely
guide
personalized
treatment.
Most
CTC
detection
systems
based
on
epithelial
markers
that
may
fail
detect
EMT
Therefore,
it
clinically
important
identify
new
types.
In
this
study,
bioinformatics
analysis
experimental
assays
showed
trophoblast
cell
surface
antigen
2
(TROP2),
a
target
molecule
for
advanced
palliative
treatment
triple-negative
breast
cancer
(TNBC),
was
highly
expressed
in
TNBC
tissues
cells.
Furthermore,
TROP2
can
promote
migration
invasion
by
upregulating
markers.
The
specificity
potential
as
an
EMT-associated
marker
were
evaluated
flow
cytometry,
immunofluorescence,
spiking
experiments,
well-established
assay.
results
indicated
novel
EMT,
providing
basis
more
efficacious
encompass
heterogeneity
patients
TNBC.
In
this
study,
we
systematically
investigated
the
interactions
between
Cu
2+
and
various
biomolecules,
including
double-stranded
DNA,
Y-shaped
DNA
nanospheres,
double
strand
of
hybridization
chain
reaction
(HCR),
network
structure
cross-linked
HCR
(cHCR),
small
molecules
(PPi
His),
using
as
an
illustrative
example.
Our
research
demonstrated
that
coordination
these
biomolecules
not
only
is
suitable
for
modulating
luminescent
material
signals
through
complexation
reactions
with
but
also
enhances
signal
intensities
in
materials
based
on
chemical
by
increasing
spatial
site
resistance
local
concentration.
Building
upon
findings,
harnessed
potential
amplification
self-assembled
nanospheres
selective
modulation
calcein
conjunction
aptamer
targeting
mucin
1
a
recognition
probe.
We
applied
approach
to
analysis
circulating
tumor
cells,
lung
cancer
cell
line
A549
serving
representative
model.
assay,
utilizing
both
fluorometer
handheld
detector,
achieved
impressive
detection
limits
ag/ml
single-cell
levels
was
successfully
validated
46
clinical
samples,
yielding
100%
specificity
86.5%
sensitivity.
Consequently,
our
strategy
has
paved
way
more
portable
precise
disease
diagnosis.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(27)
Published: April 24, 2024
Abstract
Circulating
tumor
cells
(CTCs)
detection
presents
significant
advantages
in
diagnosing
liver
cancer
due
to
its
noninvasiveness,
real‐time
monitoring,
and
dynamic
tracking.
However,
the
clinical
application
of
CTCs‐based
diagnosis
is
largely
limited
by
challenges
capturing
low‐abundance
CTCs
within
a
complex
blood
environment
while
ensuring
them
alive.
Here,
an
ultrastrong
ligand,
l
‐histidine–
‐histidine
(HH),
specifically
targeting
sialylated
glycans
on
surface
CTCs,
designed.
Furthermore,
HH
integrated
into
cell‐imprinted
polymer,
constructing
hydrogel
with
precise
imprinting,
high
elasticity,
satisfactory
compatibility,
robust
anti‐interference
capacities.
These
features
endow
excellent
capture
efficiency
(>95%)
for
peripheral
blood,
as
well
ability
release
controllably
Clinical
tests
substantiate
accurate
differentiation
between
cancer,
cirrhosis,
healthy
groups
using
this
method.
The
remarkable
diagnostic
accuracy
(94%),
lossless
material
reversibility,
cost‐effectiveness
($6.68
per
sample)
make
HH‐based
potentially
revolutionary
technology
single‐cell
analysis.
Journal of Hematology & Oncology,
Journal Year:
2025,
Volume and Issue:
18(1)
Published: Jan. 29, 2025
N7-methylguanosine
(m7G)
is
an
important
RNA
modification
involved
in
epigenetic
regulation
that
commonly
observed
both
prokaryotic
and
eukaryotic
organisms.
Their
influence
on
the
synthesis
processing
of
messenger
RNA,
ribosomal
transfer
allows
m7G
modifications
to
affect
diverse
cellular,
physiological,
pathological
processes.
are
pivotal
human
diseases,
particularly
cancer
progression.
On
one
hand,
modification-associated
modulate
tumour
progression
malignant
biological
characteristics,
including
sustained
proliferation
signalling,
resistance
cell
death,
activation
invasion
metastasis,
reprogramming
energy
metabolism,
genome
instability,
immune
evasion.
This
suggests
they
may
be
novel
therapeutic
targets
for
treatment.
other
aberrant
expression
molecules
linked
clinicopathological
staging,
lymph
node
unfavourable
prognoses
patients
with
cancer,
indicating
their
potential
as
biomarkers.
review
consolidates
discovery,
identification,
detection
methodologies,
functional
roles
modification,
analysing
mechanisms
by
which
contribute
development,
exploring
clinical
applications
diagnostics
therapy,
thereby
providing
innovative
strategies
identification
targeted
