Chronic inflammation in the etiology of disease across the life span

Nature Medicine, Journal Year: 2019, Volume and Issue: 25(12), P. 1822 - 1832

Published: Dec. 1, 2019

Language: Английский

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Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut

Cell, Journal Year: 2020, Volume and Issue: 181(6), P. 1307 - 1328.e15

Published: June 1, 2020

Language: Английский

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Impact of Circadian Disruption on Cardiovascular Function and Disease

Trends in Endocrinology and Metabolism, Journal Year: 2019, Volume and Issue: 30(10), P. 767 - 779

Published: Aug. 16, 2019

Language: Английский

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U-Sleep: resilient high-frequency sleep staging

npj Digital Medicine, Journal Year: 2021, Volume and Issue: 4(1)

Published: April 15, 2021

Sleep disorders affect a large portion of the global population and are strong predictors morbidity all-cause mortality. staging segments period sleep into sequence phases providing basis for most clinical decisions in medicine. Manual is difficult time-consuming as experts must evaluate hours polysomnography (PSG) recordings with electroencephalography (EEG) electrooculography (EOG) data each patient. Here, we present U-Sleep, publicly available, ready-to-use deep-learning-based system automated ( sleep.ai.ku.dk ). U-Sleep fully convolutional neural network, which was trained evaluated on PSG from 15,660 participants 16 studies. It provides accurate segmentations across wide range patient cohorts protocols not considered when building system. works arbitrary combinations typical EEG EOG channels, its special deep learning architecture can label stages at shorter intervals than 30 s periods used during training. We show that these labels provide additional diagnostic information lead to new ways analyzing sleep. performs par state-of-the-art automatic systems multiple datasets, even if other were built specifically particular data. A comparison consensus-scores previously unseen clinic shows accurately best human experts. support workflow medical experts, decreases healthcare costs, highly expertize lacking.

Language: Английский

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Association between sleep duration and depression in US adults: A cross-sectional study

Journal of Affective Disorders, Journal Year: 2021, Volume and Issue: 296, P. 183 - 188

Published: Sept. 27, 2021

Evidence of an association between sleep duration and depression was inconsistent.Adults who participated in the National Health Nutrition Examination Survey (NHANES) from 2009 to 2016 were included. Multivariable logistic regression used evaluate depression.Among 25,962 participants (mean age 48.1 years; 49.2% male) this study, 23,636 had a score <10 2,326 ≥ 10. After adjustment for gender, age, race/ethnicity, education, marital status, annual family income, BMI, alcohol smoking hypertension, diabetes, dyslipidemia, work activity, physical activity risk factors, short odds ratios (OR) 1.86 (95% confidence interval 1.59, 2.17) long OR 1.49 1.22, 1.83) incident depression. Further analysis revealed U-shaped When < 8 hours, increased is associated with significantly lower (OR = 0.68 [95% CI 0.64, 0.71], P 0.001). increase 1.32 [95%CI 1.23, 1.41], 0.001).Sleep independently higher Not only insufficient but excessive also

Language: Английский

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BMAL1-Downregulation Aggravates Porphyromonas Gingivalis -Induced Atherosclerosis by Encouraging Oxidative Stress

Circulation Research, Journal Year: 2020, Volume and Issue: 126(6)

Published: Feb. 11, 2020

Atherosclerotic cardiovascular diseases are the leading cause of mortality worldwide. considered as chronic inflammation processes. In addition to risk factors associated with system itself, pathogenic bacteria such periodontitis-associated Porphyromonas gingivalis (P gingivalis) also closely correlated development atherosclerosis, but underlying mechanisms still elusive. To elucidate P gingivalis-accelerated atherosclerosis and explore novel therapeutic strategies atherosclerotic diseases. Bmal1-/- (brain muscle Arnt-like protein 1) mice, ApoE-/- Bmal1-/-ApoE-/- conditional endothelial cell Bmal1 knockout mice (Bmal1fl/fl; Tek-Cre mice), corresponding jet-legged mouse model were used. Pgingivalis accelerates progression by triggering arterial oxidative stress inflammatory responses in accompanied perturbed circadian clock. Circadian clock disruption boosts gingivalis-induced progression. The mechanistic dissection shows that infection activates TLRs-NF-κB signaling axis, which subsequently recruits DNMT-1 methylate BMAL1 promoter thus suppresses transcription. downregulation releases CLOCK, phosphorylates p65 further enhances NF-κB signaling, elevating response human aortic cells. Besides, exhibits joint administration metronidazole melatonin serves an effective strategy for treating via NF-κB-BMAL1-NF-κB loop. Melatonin promising auxiliary medications toward

Language: Английский

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Feasibility of time-restricted eating and impacts on cardiometabolic health in 24-h shift workers: The Healthy Heroes randomized control trial

Cell Metabolism, Journal Year: 2022, Volume and Issue: 34(10), P. 1442 - 1456.e7

Published: Oct. 1, 2022

Over a quarter of the workforce in industrialized countries does shift work, which increases risk for cardiometabolic disease. Yet workers are often excluded from lifestyle intervention studies to reduce this risk. In randomized control trial with 137 firefighters who work 24-h shifts (23-59 years old, 9% female), 12 weeks 10-h time-restricted eating (TRE) was feasible, TRE participants decreasing their window (baseline, mean 14.13 h, 95% CI 13.78-14.47 h; intervention, 11.13 10.73-11.54 p = 3.29E-17) no adverse effects, and improved quality life assessed via SF-36 (ClinicalTrials.gov: NCT03533023). Compared standard care (SOC) arm, significantly decreased VLDL particle size. elevated risks at baseline, there were significant reductions compared SOC glycated hemoglobin A1C diastolic blood pressure. For individuals working schedule, is feasible can improve health, especially increased VIDEO ABSTRACT.

Language: Английский

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Sleep Deprivation and Insomnia in Adolescence: Implications for Mental Health

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(4), P. 569 - 569

Published: March 28, 2023

Sleep changes significantly throughout the human lifespan. Physiological modifications in sleep regulation, common with many mammals (especially circadian rhythms), predispose adolescents to loss until early adulthood. Adolescents are one-sixth of all beings and at high risk for mental diseases (particularly mood disorders) self-injury. This has been attributed incredible number occurring a limited time window that encompasses rapid biological psychosocial modifications, which teens at-risk behaviors. Adolescents’ patterns have investigated as biunivocal cause potential damaging conditions, insufficient may be both consequence health problems. The recent COVID-19 pandemic particular made detrimental contribution adolescents’ quality. In this review, we aim summarize knowledge field explore implications (and future adults’) physical health, well outline strategies prevention.

Language: Английский

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Sleep Tracking of a Commercially Available Smart Ring and Smartwatch Against Medical-Grade Actigraphy in Everyday Settings: Instrument Validation Study

JMIR mhealth and uhealth, Journal Year: 2020, Volume and Issue: 8(10), P. e20465 - e20465

Published: Sept. 23, 2020

Background Assessment of sleep quality is essential to address poor and understand changes. Owing the advances in Internet Things wearable technologies, monitoring under free-living conditions has become feasible practicable. Smart rings smartwatches can be employed perform mid- or long-term home-based monitoring. However, validity such wearables should investigated terms parameters. Sleep validation studies are mostly limited short-term laboratory tests; there a need for study assess attributes everyday settings, where users engage their daily routines. Objective This aims evaluate parameters Oura ring along with Samsung Gear Sport watch comparison medically approved actigraphy device midterm setting, Methods We conducted which 45 healthy individuals (23 women 22 men) were tracked 7 days. Total time (TST), efficiency (SE), wake after onset (WASO) assessed using paired t tests, Bland-Altman plots, Pearson correlation. The also considering gender participants as dependent variable. Results found significant correlations between ring’s actigraphy’s TST (r=0.86; P<.001), WASO (r=0.41; SE (r=0.47; P<.001). Comparing showed correlation (r=0.59; mean differences TST, WASO, within satisfactory ranges, although (P<.001); ranges watch, was slightly higher than range (31.27, SD 35.15). considerably those ring. difference (P<.001) female male groups. Conclusions In sample population adults, both have acceptable indicate actigraphy, but outperforms nonstaging

Language: Английский

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Sleep Duration and Risks of Incident Cardiovascular Disease and Mortality Among People With Type 2 Diabetes

Diabetes Care, Journal Year: 2022, Volume and Issue: 46(1), P. 101 - 110

Published: Nov. 16, 2022

OBJECTIVE People with type 2 diabetes may have insufficient or prolonged sleep that could accelerate cardiovascular disease (CVD) onset, but existing evidence from prospective studies has been limited. We examined the association of duration CVD incidence and mortality in this high-risk population. RESEARCH DESIGN AND METHODS This study included 18,876 participants UK Biobank who were free cancer at baseline. Habitual was obtained using a baseline questionnaire. Cox proportional hazards regression models used to examine between events. RESULTS During an average follow-up 11.0–12.0 years, we documented 2,570 incident cases atherosclerotic (ASCVD) 598 deaths. Compared sleeping for 7 h/day, multivariable-adjusted hazard ratios ≤5 ≥10 h/day 1.26 (95% CI 1.08, 1.48) 1.41 (1.16, 1.70) ASCVD, 1.22 (0.99, 1.50) 1.16 (0.88, 1.52) coronary artery disease, 1.70 (1.23, 2.35) 2.08 (1.44, 3.01) ischemic stroke, 1.02 (0.72, 1.44) 1.45 (1.01, 2.10) peripheral 1.42 (1.02, 1.97) 1.85 (1.30, 2.64) mortality. Similar results observed most sensitivity analyses aimed address potential reverse causation joint metabolic control severity status. CONCLUSIONS Short long durations independently associated increased risks onset death among people diabetes.

Language: Английский

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