Health position paper and redox perspectives - Disease burden by transportation noise DOI Creative Commons
Mette Sørensen, Göran Pershagen, Jesse D. Thacher

et al.

Redox Biology, Journal Year: 2023, Volume and Issue: 69, P. 102995 - 102995

Published: Dec. 19, 2023

Transportation noise is a ubiquitous urban exposure. In 2018, the World Health Organization concluded that chronic exposure to road traffic risk factor for ischemic heart disease. contrast, they quality of evidence link other diseases was very low moderate. Since then, several studies on impact various have been published. Also, investigating mechanistic pathways underlying noise-induced health effects are emerging. We review current regarding and related disease-mechanisms. Several high-quality cohort consistently found be associated with higher disease, failure, diabetes, all-cause mortality. Furthermore, recent indicated railway may increase not commonly investigated in an environmental context, including breast cancer, dementia, tinnitus. The harmful activation physiological stress response nighttime sleep disturbance. Oxidative inflammation downstream hormone signaling dysregulated circadian rhythms identified as major disease-relevant pathomechanistic drivers. discuss role reactive oxygen species present results from antioxidant interventions. Lastly, we provide overview oxidative markers adverse redox processes reported noise-exposed animals humans. This position paper summarizes all available epidemiological, clinical, preclinical transportation important public discusses its implications population level.

Language: Английский

Transportation noise pollution and cardiovascular disease DOI

Thomas Münzel,

Mette Sørensen, Andreas Daiber

et al.

Nature Reviews Cardiology, Journal Year: 2021, Volume and Issue: 18(9), P. 619 - 636

Published: March 31, 2021

Language: Английский

Citations

374
Circadian rhythm as a therapeutic target DOI
Wei Ruan, Xiaoyi Yuan, Holger K. Eltzschig

et al.

Nature Reviews Drug Discovery, Journal Year: 2021, Volume and Issue: 20(4), P. 287 - 307

Published: Feb. 15, 2021

Language: Английский

Citations

299
The Circadian Syndrome: is the Metabolic Syndrome and much more! DOI Creative Commons
Paul Zimmet,

K. G. M. M. Alberti,

Naftali Stern

et al.

Journal of Internal Medicine, Journal Year: 2019, Volume and Issue: 286(2), P. 181 - 191

Published: May 13, 2019

Abstract The Metabolic Syndrome is a cluster of cardio‐metabolic risk factors and comorbidities conveying high both cardiovascular disease type 2 diabetes. It responsible for huge socio‐economic costs with its resulting morbidity mortality in most countries. underlying aetiology this clustering has been the subject much debate. More recently, significant interest focussed on involvement circadian system, major regulator almost every aspect human health metabolism. Circadian now implicated several chronic diseases including diabetes disease. There increasing evidence connecting disturbances rhythm not only key components but also main sleep disturbances, depression, steatohepatitis cognitive dysfunction. Based this, we propose that disruption may be an important aetiological factor suggest it renamed ‘Circadian Syndrome’. With increased recognition Syndrome’, medicine, through timing exercise, light exposure, food consumption, dispensing medications sleep, likely to play greater role maintenance individual population future.

Language: Английский

Citations

278
Functions of Gut Microbiota Metabolites, Current Status and Future Perspectives DOI Creative Commons
Juan Liu, Yuzhu Tan, Hao Cheng

et al.

Aging and Disease, Journal Year: 2022, Volume and Issue: 13(4), P. 1106 - 1106

Published: Jan. 1, 2022

Gut microbiota, a collection of microorganisms that live within gastrointestinal tract, provides crucial signaling metabolites for the physiological hosts. In healthy state, gut microbiota are helpful maintaining basic functions hosts, whereas disturbed production these can lead to numerous diseases such as metabolic diseases, cardiovascular neurodegenerative and cancer. Although there many reviews about specific mechanisms on is no comprehensive summarization metabolites. this Opinion, we discuss knowledge including types their ways acting targets. addition, summarize pathologic in health shaping composition nutrition. This paper be understanding roles thus provide guidance developing suitable therapeutic strategies combat microbial-driven improve health.

Language: Английский

Citations

249
Time-restricted Eating for the Prevention and Management of Metabolic Diseases DOI Open Access
Emily N. C. Manoogian, Lisa S. Chow, Pam R. Taub

et al.

Endocrine Reviews, Journal Year: 2021, Volume and Issue: 43(2), P. 405 - 436

Published: Sept. 22, 2021

Time-restricted feeding (TRF, animal-based studies) and time-restricted eating (TRE, humans) are an emerging behavioral intervention approach based on the understanding of role circadian rhythms in physiology metabolism. In this approach, all calorie intake is restricted within a consistent interval less than 12 hours without overtly attempting to reduce calories. This article will summarize origin TRF/TRE starting with concept chronic rhythm disruption increasing risk for metabolic diseases. Circadian usually perceived as sleep-wake cycle dependent arising from central nervous system. However, recent discovery peripheral organs plasticity these response changes nutrition availability raised possibility that adopting daily short window can sustain robust rhythm. Preclinical animal studies have demonstrated proof identified potential mechanisms driving TRF-related benefits. Pilot human reported promising results reducing obesity, diabetes, cardiovascular Epidemiological indicated maintaining long overnight fast, which similar TRE, significantly risks Despite early successes, more clinical mechanistic needed implement TRE alone or adjuvant lifestyle prevention management

Language: Английский

Citations

204
Environmental risk factors and cardiovascular diseases: a comprehensive expert review DOI Creative Commons

Thomas Münzel,

Omar Hahad, Mette Sørensen

et al.

Cardiovascular Research, Journal Year: 2021, Volume and Issue: 118(14), P. 2880 - 2902

Published: Sept. 30, 2021

Abstract Non-communicable diseases (NCDs) are fatal for more than 38 million people each year and thus the main contributors to global burden of disease accounting 70% mortality. The majority these deaths caused by cardiovascular (CVD). risk NCDs is strongly associated with exposure environmental stressors such as pollutants in air, noise exposure, artificial light at night, climate change, including heat extremes, desert storms, wildfires. In addition traditional factors CVD diabetes, arterial hypertension, smoking, hypercholesterolaemia, genetic predisposition, there a growing body evidence showing that physicochemical environment contribute significantly high NCD numbers. Furthermore, urbanization accumulation intensification stressors. This comprehensive expert review will summarize epidemiology pathophysiology focus on NCDs. We also discuss solutions mitigation measures lower impact CVD.

Language: Английский

Citations

186
Branched-chain amino acids in cardiovascular disease DOI
Robert W. McGarrah, Phillip J. White

Nature Reviews Cardiology, Journal Year: 2022, Volume and Issue: 20(2), P. 77 - 89

Published: Sept. 5, 2022

Language: Английский

Citations

144
Cortisol on Circadian Rhythm and Its Effect on Cardiovascular System DOI Open Access
Nor Amira Syahira Mohd Azmi, Norsham Juliana, Sahar Azmani

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2021, Volume and Issue: 18(2), P. 676 - 676

Published: Jan. 14, 2021

The synthesis and secretion of cortisol are controlled by the hypothalamic–pituitary–adrenal axis. Cortisol exhibits a proper 24-h circadian rhythm that affects brain, autonomic nervous system, heart, vasculature prepares cardiovascular system for optimal function during these anticipated behavioral cycles. A literature search was conducted using databases such as Google Scholar, PubMed, Scopus. Relevant terms included “circadian cardiovascular”, “cortisol”, “cortisol acute coronary syndrome”, arrhythmias”, sudden cardiac death”, stroke”, “cardioprotective agents”. total 120 articles were obtained on basis above search. Lower levels seen at beginning sleep, while there rise towards end with highest level reached moment individual wakes up. In present review, we discuss role 11β-hydroxysteroid dehydrogenase (11β-HSD1), which is novel molecular target interest treating metabolic syndrome type-2 diabetes mellitus. 11β-HSD1 major determinant excess, its inhibition alleviates abnormalities. review highlights cortisol, controls rhythm, describes effect system. provides platform future potential cardioprotective therapeutic agents.

Language: Английский

Citations

142
Magnetic field effects in biology from the perspective of the radical pair mechanism DOI Creative Commons
Hadi Zadeh‐Haghighi, Christoph Simon

Journal of The Royal Society Interface, Journal Year: 2022, Volume and Issue: 19(193)

Published: Aug. 1, 2022

Hundreds of studies have found that weak magnetic fields can significantly influence various biological systems. However, the underlying mechanisms behind these phenomena remain elusive. Remarkably, energies implicated in effects are much smaller than thermal energies. Here, we review observations, and suggest an explanation based on radical pair mechanism, which involves quantum dynamics electron nuclear spins transient molecules. While mechanism has been studied detail context avian magnetoreception, reviewed here show magnetosensitivity is widespread throughout biology. We field physiological functions, discussing static, hypomagnetic oscillating fields, as well isotope effects. then a potential unifying model for described effects, discuss plausible candidate molecules pairs. recent proposing provides explanations xenon anaesthesia lithium treatment hyperactivity, circadian clock, neurogenesis microtubule assembly. conclude by future lines investigation this exciting new area

Language: Английский

Citations

126
Circadian rhythms and cancers: the intrinsic links and therapeutic potentials DOI Creative Commons
Li Zhou, Zhe Zhang, Edouard C. Nice

et al.

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: March 4, 2022

The circadian rhythm is an evolutionarily conserved time-keeping system that comprises a wide variety of processes including sleep-wake cycles, eating-fasting and activity-rest coordinating the behavior physiology all organs for whole-body homeostasis. Acute disruption may lead to transient discomfort, whereas long-term irregular will result in dysfunction organism, therefore increasing risks numerous diseases especially cancers. Indeed, both epidemiological experimental evidence has demonstrated intrinsic link between dysregulated cancer. Accordingly, rapidly understanding molecular mechanisms rhythms opening new options cancer therapy, possibly by modulating clock. In this review, we first describe general regulators their functions on addition, provide insights into underlying how several types (including sleep-wake, eating-fasting, activity-rest) can drive progression, which expand our development from clock perspective. Moreover, also summarize potential applications treatment, optional therapeutic strategy patients.

Language: Английский

Citations

91