2021 ESC Guidelines on cardiovascular disease prevention in clinical practice

European Heart Journal, Journal Year: 2021, Volume and Issue: 42(34), P. 3227 - 3337

Published: Aug. 30, 2021

The ESC Guidelines represent the views of and were produced after careful consideration scientific medical knowledge evidence available at time their publication.The is not responsible in event any contradiction, discrepancy and/or ambiguity between other official recommendations or guidelines issued by relevant public health authorities, particular relation to good use healthcare therapeutic strategies.Health professionals are encouraged take fully into account when exercising clinical judgment, as well determination implementation preventive, diagnostic strategies; however, do override, way whatsoever, individual responsibility make appropriate accurate decisions each patient's condition consultation with that patient and, where necessary, caregiver.Nor exempt from taking full updated competent order manage case light scientifically accepted data pursuant respective ethical professional obligations.It also professional's verify applicable rules regulations relating drugs devices prescription.

Language: Английский

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The Global Burden of Cardiovascular Diseases and Risk

Journal of the American College of Cardiology, Journal Year: 2022, Volume and Issue: 80(25), P. 2361 - 2371

Published: Nov. 9, 2022

Language: Английский

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Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

Nature Reviews Molecular Cell Biology, Journal Year: 2022, Volume and Issue: 23(7), P. 499 - 515

Published: Feb. 21, 2022

Language: Английский

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Recent Insights into Particulate Matter (PM2.5)-Mediated Toxicity in Humans: An Overview

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(12), P. 7511 - 7511

Published: June 19, 2022

Several epidemiologic and toxicological studies have commonly viewed ambient fine particulate matter (PM2.5), defined as particles having an aerodynamic diameter of less than 2.5 µm, a significant potential danger to human health. PM2.5 is mostly absorbed through the respiratory system, where it can infiltrate lung alveoli reach bloodstream. In reactive oxygen or nitrogen species (ROS, RNS) oxidative stress stimulate generation mediators pulmonary inflammation begin promote numerous illnesses. According most recent data, matter, PM2.5, responsible for nearly 4 million deaths globally from cardiopulmonary illnesses such heart disease, infections, chronic cancers, preterm births, other There has been increased worry in years about negative impacts this worldwide danger. The causal associations between health, toxic effects mechanisms molecular pathways described review.

Language: Английский

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2021 ESC Guidelines on cardiovascular disease prevention in clinical practice

European Journal of Preventive Cardiology, Journal Year: 2021, Volume and Issue: 29(1), P. 5 - 115

Published: Sept. 24, 2021

The ESC Guidelines represent the views of and were produced after careful consideration scientific medical knowledge evidence available at time their publication.The is not responsible in event any contradiction, discrepancy and/or ambiguity between other official recommendations or guidelines issued by relevant public health authorities, particular relation to good use healthcare therapeutic strategies.Health professionals are encouraged take fully into account when exercising clinical judgment, as well determination implementation preventive, diagnostic strategies; however, do override, way whatsoever, individual responsibility make appropriate accurate decisions each patient's condition consultation with that patient and, where necessary, caregiver.Nor exempt from taking full updated competent order manage case light scientifically accepted data pursuant respective ethical professional obligations.It also professional's verify applicable rules regulations relating drugs devices prescription.

Language: Английский

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Ambient air pollution and cardiovascular diseases: An umbrella review of systematic reviews and meta‐analyses

Journal of Internal Medicine, Journal Year: 2022, Volume and Issue: 291(6), P. 779 - 800

Published: Feb. 9, 2022

Abstract The available evidence on the effects of ambient air pollution cardiovascular diseases (CVDs) has increased substantially. In this umbrella review, we summarized current epidemiological from systematic reviews and meta‐analyses linking CVDs, with a focus geographical differences vulnerable subpopulations. We performed search strategy through multiple databases including articles between 2010 31 January 2021. quality assessment evaluated strength evidence. Of 56 included reviews, most studied outcomes were stroke (22 reviews), all‐cause CVD mortality, morbidity (19). strongest was found higher short‐ long‐term exposure mortality morbidity, stroke, blood pressure, ischemic heart (IHD). Short‐term exposures to particulate matter <2.5 μm (PM 2.5 ), <10 10 nitrogen oxides (NO x ) consistently associated risks hypertension triggering myocardial infarction (MI), (fatal nonfatal). Long‐term PM largely risk atherosclerosis, incident MI, hypertension, mortality. Few other arrhythmias, atrial fibrillation, or failure but they generally reported positive statistical associations. Stronger associations in Asian countries subpopulations, especially among elderly, cardiac patients, people weight status. Consistent experimental data, comprehensive review strong that levels increase IHD. These results emphasize importance reducing alarming across globe, Asia,

Language: Английский

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Pollution and the Heart

New England Journal of Medicine, Journal Year: 2021, Volume and Issue: 385(20), P. 1881 - 1892

Published: Nov. 10, 2021

ardiovascular diseases are the world's leading cause of disability and death.Such were responsible in 2019 for an estimated 18.6 million deaths globally 957,000 United States. 1,2reat gains have been made reducing incidence cardiovascular disease related mortality high-income countries.Identification risk factors such as tobacco use, hypertension, dyslipidemia, physical inactivity, diabetes large, prospective, multiyear epidemiologic studies has key.Recognition these increased awareness diseases, enhanced early detection, guided treatment prevention.These advances contributed to more than a 50% decline from States since 1950. 3ollution -unwanted material released into environment by human activity -is another important yet often overlooked factor (Fig. 1). 4 The Global Burden Disease (GBD) study estimates that pollution was 9 worldwide 2019, 61.9% which due disease, including ischemic heart (31.7%) stroke (27.7%) 2A). 1 These numbers, large they are, almost certainly undercount full contribution global burden because based on only subset environmental factors. 4ntil now, reduction received scant attention programs control largely absent guidelines regarding prevention focused exclusively individual behavioral metabolic 5This is omission, incorporation could save millions lives.In this review, we summarize current evidence linking suggest evidence-based strategies prevention.We discuss exposure persons but argue lasting pollution-related can be achieved through government-supported interventions societal scale at its source encourage rapid transition clean energy.We note actions will also slow pace climate change thus produce double benefit.Only multipronged strategy combines with epidemic contained. A ir Pollu tionAir complex mixture varies concentration composition according time place greatly influenced weather. 5,6It includes particulate gaseous primary pollutants nitrogen oxides (NO x ), sulfur dioxide, carbon monoxide, directly atmosphere,

Language: Английский

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Environmental risk factors and cardiovascular diseases: a comprehensive expert review

Cardiovascular Research, Journal Year: 2021, Volume and Issue: 118(14), P. 2880 - 2902

Published: Sept. 30, 2021

Abstract Non-communicable diseases (NCDs) are fatal for more than 38 million people each year and thus the main contributors to global burden of disease accounting 70% mortality. The majority these deaths caused by cardiovascular (CVD). risk NCDs is strongly associated with exposure environmental stressors such as pollutants in air, noise exposure, artificial light at night, climate change, including heat extremes, desert storms, wildfires. In addition traditional factors CVD diabetes, arterial hypertension, smoking, hypercholesterolaemia, genetic predisposition, there a growing body evidence showing that physicochemical environment contribute significantly high NCD numbers. Furthermore, urbanization accumulation intensification stressors. This comprehensive expert review will summarize epidemiology pathophysiology focus on NCDs. We also discuss solutions mitigation measures lower impact CVD.

Language: Английский

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Climate change and cardiovascular disease: implications for global health

Nature Reviews Cardiology, Journal Year: 2022, Volume and Issue: 19(12), P. 798 - 812

Published: June 7, 2022

Language: Английский

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Secondary organic aerosol association with cardiorespiratory disease mortality in the United States

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Dec. 16, 2021

Abstract Fine particle pollution, PM 2.5 , is associated with increased risk of death from cardiorespiratory diseases. A multidecadal shift in the United States (U.S.) composition towards organic aerosol as well advances predictive algorithms for secondary (SOA) allows novel examinations role components on mortality. Here we show SOA strongly county-level rates U.S. independent total mass association largest associations located southeastern Compared to variability across 3.5× greater per capita On a basis, 6.5× higher rate mortality than and biogenic anthropogenic carbon sources both play overall Our results suggest reducing health impacts requires consideration SOA.

Language: Английский

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