Progress in Cardiovascular Diseases, Journal Year: 2024, Volume and Issue: unknown
Published: May 1, 2024
Language: Английский
Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136400 - 136400
Published: Nov. 4, 2024
Language: Английский
Citations
12
Current Diabetes Reports, Journal Year: 2024, Volume and Issue: 24(7), P. 158 - 166
Published: May 3, 2024
Language: Английский
Citations
11
American Journal of Preventive Cardiology, Journal Year: 2024, Volume and Issue: 18, P. 100648 - 100648
Published: March 23, 2024
Triglycerides play a crucial role in the efficient storage of energy body. Mild and moderate hypertriglyceridemia (HTG) is heterogeneous disorder with significant association atherosclerotic cardiovascular disease (ASCVD), including myocardial infarction, ischemic stroke, peripheral artery represents an important component residual ASCVD risk statin treated patients despite optimal low-density lipoprotein cholesterol reduction. Individuals severe HTG (>1,000 mg/dL) rarely develop atherosclerosis but have incremental incidence acute pancreatitis morbidity mortality. can occur from combination genetic (both mono polygenic) environmental factors poor diet, low physical activity, obesity, medications, diseases like insulin resistance other endocrine pathologies. potential target for reduction, however data on reduction by treating still lacking HTG-associated occurs too to effectively demonstrate treatment benefit. In this review, we address key aspects pathophysiology examine mechanisms background current emerging therapies management HTG.
Language: Английский
Citations
10
European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 968, P. 176433 - 176433
Published: Feb. 16, 2024
Language: Английский
Citations
9
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: Feb. 6, 2025
Language: Английский
Citations
1
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: March 25, 2025
Abstract Electronic health records (EHRs) coupled with large-scale biobanks offer great promises to unravel the genetic underpinnings of treatment efficacy. However, medication-induced biomarker trajectories stemming from such remain poorly studied. Here, we extract clinical and medication prescription data EHRs conduct GWAS rare variant burden tests in UK Biobank (discovery) All Us program (replication) on ten cardiometabolic drug response outcomes including lipid statins, HbA1c metformin blood pressure antihypertensives (N = 932-28,880). Our discovery analyses participants European ancestry recover previously reported pharmacogenetic signals at genome-wide significance level ( APOE , LPA SLCO1B1 ) a novel association GIMAP5 metformin. Importantly, these associations are treatment-specific not associated progression medication-naive individuals. We also found polygenic risk scores predict response, though they explained less than 2% variance. In summary, present an EHR-based framework study genetics systematically investigated common contribution phenotypes 41,732 14,277 participants.
Language: Английский
Citations
1
Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13
Published: Nov. 25, 2022
Apolipoproteins (APOs), the primary protein moiety of lipoproteins, are known for their crucial role in lipid traffic and metabolism. Despite extensive exploration APOs cardiovascular diseases, roles cancers did not attract enough attention. Recently, research focusing on has flourished. Multiple studies demonstrate interaction with classical pathways tumorigenesis. Besides, dysregulation may indicate cancer occurrence progression, thus serving as potential biomarkers patients. Herein, we summarize mechanisms involved development various cancers, applications genetic polymorphism associated risk. Additionally, also discuss anti-cancer therapies by virtue APOs. The comprehensive review advance understanding mechanisms. We hope that it will provide novel clues new therapeutic strategies cancers.
Language: Английский
Citations
31
The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2023, Volume and Issue: 109(2), P. 321 - 332
Published: July 11, 2023
Abstract High-density lipoprotein (HDL) contributes to reverse cholesterol transport, which is 1 of the main explanations for described inverse association between HDL-cholesterol (HDL-C) and atherosclerotic cardiovascular disease (ASCVD) risk. However, efforts therapeutically raise HDL-C levels with niacin, fibrates, or cholesteryl ester transfer protein inhibitors have not demonstrated a reduction in ASCVD events when compared placebo among individuals treated statins. Furthermore, mendelian randomization studies suggest that unlikely be direct biologic variable impacting More recently, observations from well-conducted epidemiologic indicated nonlinear U-shaped relationship subclinical atherosclerosis, very high (≥80 mg/dL men, ≥100 women) paradoxically associated higher all-cause ASCVD-related mortality. These universal protective factor atherosclerosis. Thus, there are several opportunities reframing contribution risk related clinical calculators. Here, we examine our growing understanding its role assessment, treatment, prevention. We discuss biological functions normative values relation demographics lifestyle markers. then summarize original observed more recent evidence indicating an elevated at levels. Through this process, advance discussion regarding future assessment identify knowledge gaps pertaining precise atherosclerosis ASCVD.
Language: Английский
Citations
21
Pharmacological Research, Journal Year: 2023, Volume and Issue: 195, P. 106873 - 106873
Published: July 28, 2023
The subendothelial retention of apolipoprotein B (apoB)-containing lipoproteins is a critical step in the initiation pro-atherosclerotic processes. Recent genetic and clinical evidence strongly supports concept that lipid content particles secondary to number circulating atherogenic are trapped within arterial lumen. Since each low-density (LDL) particle contains one apoB molecule, as do intermediate density lipoprotein (IDL) very (VLDL) particles, level represents total lipoproteins, which independent density, not affected by heterogeneity cholesterol (clinically evaluated LDL-cholesterol level). From this perspective, proposed better proxy for assessing atherosclerotic cardiovascular disease risk, especially specific subgroups patients, including subjects with diabetes mellitus, multiple cardiometabolic risk factors (obesity, metabolic syndrome, insulin resistance, hypertension) high triglyceride levels low levels. Therefore, given causal role (ASCVD) development, routine measurement both utmost importance properly estimate global determine 'residual' ASCVD patients receiving therapy, well monitor therapeutic effectiveness.
Language: Английский
Citations
17
Metabolites, Journal Year: 2024, Volume and Issue: 14(4), P. 218 - 218
Published: April 12, 2024
Metabolic-associated fatty liver disease (MAFLD), characterized primarily by hepatic steatosis, has become the most prevalent worldwide, affecting approximately two-fifths of global population. The pathogenesis MAFLD is extremely complex, and to date, there are no approved therapeutic drugs for clinical use. Considerable evidence indicates that various metabolic disorders play a pivotal role in progression MAFLD, including lipids, carbohydrates, amino acids, micronutrients. In recent years, medicinal properties natural products have attracted widespread attention, numerous studies reported their efficacy ameliorating subsequently alleviating MAFLD. This review aims summarize metabolic-associated pathological mechanisms as well regulate pathways alleviate
Language: Английский
Citations
8