Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: Oct. 20, 2023
Abstract
Insufficient
drug
loading
and
leakage
of
payload
remain
major
challenges
in
designing
liposome-based
delivery
systems.
These
phenomena
can
limit
duration
effect
cause
toxicity.
Targeting
the
rate-limiting
step
release
from
liposomes,
we
modify
(aromatized)
them
to
have
aromatic
groups
within
their
lipid
bilayers.
Aromatized
liposomes
are
designed
with
synthetic
phospholipids
covalently
conjugated
onto
acyl
chains.
The
optimized
aromatized
liposome
increases
significantly
decreases
burst
a
broad
range
payloads
(small
molecules
macromolecules,
different
degrees
hydrophilicity)
extends
release.
encapsulating
anesthetic
tetrodotoxin
(TTX)
achieve
markedly
prolonged
decreased
toxicity
an
application
where
used
clinically:
local
anesthesia,
even
though
TTX
is
hydrophilic
small
molecule
which
typically
difficult
encapsulate.
Aromatization
bilayers
improve
performance
liposomal
Small,
Journal Year:
2017,
Volume and Issue:
13(43)
Published: Oct. 16, 2017
Abstract
A
major
obstacle
facing
brain
diseases
such
as
Alzheimer's
disease,
multiple
sclerosis,
tumors,
and
strokes
is
the
blood–brain
barrier
(BBB).
The
BBB
prevents
passage
of
certain
molecules
pathogens
from
circulatory
system
into
brain.
Therefore,
it
nearly
impossible
for
therapeutic
drugs
to
target
diseased
cells
without
assistance
carriers.
Nanotechnology
an
area
growing
public
interest;
nanocarriers,
polymer‐based,
lipid‐based,
inorganic‐based
nanoparticles
can
be
engineered
in
different
sizes,
shapes,
surface
charges,
they
modified
with
functional
groups
enhance
their
penetration
targeting
capabilities.
Hence,
understanding
interaction
between
nanomaterials
crucial.
In
this
Review,
components
properties
are
revisited
types
nanocarriers
that
most
commonly
used
drug
delivery
discussed.
factors
affect
across
elaborated
upon
review.
Additionally,
recent
developments
nanoformulations
nonconventional
strategies
highlighted.
Finally,
challenges
considerations
development
nanomedicines
overall
objective
broaden
design
develop
treatment
diseases.
Advanced Science,
Journal Year:
2020,
Volume and Issue:
7(17)
Published: June 14, 2020
The
incorporation
of
new
modalities
into
chemotherapy
greatly
enhances
the
anticancer
efficacy
combining
merits
each
treatment,
showing
promising
potentials
in
clinical
translations.
Herein,
a
hybrid
nanomedicine
(Au/FeMOF@CPT
NPs)
is
fabricated
using
metal-organic
framework
(MOF)
nanoparticles
and
gold
(Au
as
building
blocks
for
cancer
chemo/chemodynamic
therapy.
MOF
NPs
are
used
vehicles
to
encapsulate
camptothecin
(CPT),
hybridization
by
Au
improves
stability
physiological
environment.
Triggered
high
concentration
phosphate
inside
cells,
Au/FeMOF@CPT
effectively
collapse
after
internalization,
resulting
complete
drug
release
activation
cascade
catalytic
reactions.
intracellular
glucose
can
be
oxidized
produce
hydrogen
dioxide,
which
further
utilized
chemical
fuel
Fenton
reaction,
thus
realizing
synergistic
efficacy.
Benefitting
from
enhanced
permeability
retention
effect
sophisticated
fabrications,
blood
circulation
time
tumor
accumulation
significantly
increased.
In
vivo
results
demonstrate
that
combination
chemodynamic
therapy
suppresses
growth,
meantime
systemic
toxicity
this
avoided.
Journal of the American Chemical Society,
Journal Year:
2019,
Volume and Issue:
141(18), P. 7235 - 7239
Published: April 22, 2019
The
morphology
controlled
molecular
assemblies
play
vital
roles
in
biological
systems.
Here
we
present
endogenous
reactive
oxygen
species
(ROS)-triggered
transformation
of
polymer-peptide
conjugates
(PPCs)
for
cooperative
interaction
with
mitochondria,
exhibiting
high
tumor
therapeutic
efficacy.
PPCs
are
composed
(i)
a
β-sheet-forming
peptide
KLVFF
conjugated
poly(ethylene
glycol)
through
ROS-cleavable
thioketal,
(ii)
mitochondria-targeting
cytotoxic
KLAK,
and
(iii)
poly(vinyl
alcohol)
backbone.
self-assembled
nanoparticles
can
enter
cells
target
mitochondria.
Because
overgenerated
ROS
around
mitochondria
most
cancer
cells,
the
thioketal
linker
be
cleaved,
leading
to
from
fibrous
nanostructures.
As
result,
locational
nanofibers
exposure
KLAK
exhibit
enhanced
multivalent
interactions
which
causes
selective
cytotoxicity
against
powerful
suppression
efficacy
vivo.
first
example
ROS-triggered
intracellular
transformation,
assembly
strategy
vivo
may
provide
new
insight
disease
diagnosis
therapy
targeting
site.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2020,
Volume and Issue:
8
Published: Feb. 11, 2020
Polymeric
biomaterials
have
found
widespread
applications
in
nanomedicine,
and
PLGA
particular
has
been
successfully
implemented
numerous
drug
delivery
formulations
due
to
its
synthetic
malleability
biocompatibility.
However,
the
need
for
preconception
these
is
increasing,
this
can
be
achieved
by
selection
elimination
of
design
variables
order
systems
tailored
their
specific
applications.
The
starting
materials
preparation
methods
shown
influence
various
parameters
PLGA-based
nanocarriers
implementation
systems,
while
computational
simulations
as
a
component
formulation
studies
provide
valuable
information
on
characteristics.
This
review
provides
critical
summary
synthesis
bio-medicine
outlines
experimental
considerations
systems.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(10)
Published: Feb. 3, 2022
Carriers
are
equally
important
as
drugs.
They
can
substantially
improve
bioavailability
of
cargos
and
safeguard
healthy
cells
from
toxic
effects
certain
therapeutics.
Recently,
polymeric
nanocarriers
(PNCs)
have
achieved
significant
success
in
delivering
drugs
not
only
to
but
also
subcellular
organelles.
Variety
natural
sources,
availability
different
synthetic
routes,
versatile
molecular
architectures,
exploitable
physicochemical
properties,
biocompatibility,
biodegradability
presented
polymers
one
the
most
desired
materials
for
nanocarrier
design.
Recent
innovative
concepts
advances
PNC-associated
nanotechnology
providing
unprecedented
opportunities
engineer
their
functions.
The
efficiency
therapeutic
loading
has
got
considerably
increased.
Structural
design-based
varieties
PNCs
widely
employed
delivery
small
molecules
genes,
proteins.
gained
ever-increasing
attention
certainly
paves
way
develop
advanced
nanomedicines.
This
article
presents
a
comprehensive
investigation
structural
influences
properties
on
drug
profiles
with
perspectives
highlighting
inevitability
incorporating
both
multi-stimuli-responsive
multi-drug
single
carrier
design
intelligent
new
emerging
research
directions
this
rapidly
developing
area.
Industrial & Engineering Chemistry Research,
Journal Year:
2019,
Volume and Issue:
59(9), P. 4134 - 4149
Published: Dec. 18, 2019
Significant
efforts
have
been
made
to
fabricate
drug-loaded
nanoparticles
for
drug
delivery.
Nanoprecipitation
is
a
simple
and
versatile
method
making
various
types
of
polymer
with
well-controlled
particle
size,
size
distribution,
surface
properties.
This
review
presents
critical
overview
three
different
widely
used
nanoprecipitation
techniques,
namely,
traditional
in
bulk
solutions,
flash
nanoprecipitation,
microfluidic-based
nanoprecipitation.
The
starts
the
comparison
these
methods
summarizing
their
key
characteristics,
advantages,
disadvantages.
Then,
synthesized
using
are
presented
including
di-block
copolymer
natural
nanoparticles.
A
special
focus
placed
on
comparing
prepared
approaches
synthesis
methods,
loading,
encapsulation
efficiency,
nanoparticle
properties
(e.g.,
PDI,
etc.),
stability.
Finally,
principle
forming
discussed
fundamentally
understand
intricate
interplay
between
mixing,
supersaturation,
nucleation,
growth,
aiming
provide
general
guideline
based
