A Global Review on Short Peptides: Frontiers and Perspectives

Molecules, Journal Year: 2021, Volume and Issue: 26(2), P. 430 - 430

Published: Jan. 15, 2021

Peptides are fragments of proteins that carry out biological functions. They act as signaling entities via all domains life and interfere with protein-protein interactions, which indispensable in bio-processes. Short peptides include fundamental molecular information for a prelude to the symphony life. have aroused considerable interest due their unique features great promise innovative bio-therapies. This work focusing on current state-of-the-art short peptide-based therapeutical developments is first global review written by researchers from continents, celebration 100 years peptide therapeutics since commencement insulin therapy 1920s. Peptide “drugs” initially played only role hormone analogs balance disorders. Nowadays, they achieve numerous biomedical tasks, can cross membranes, or reach intracellular targets. The bio-processes hardly be mimicked other chemical substances. article divided into independent sections, related either progress theranostics problems posing challenge bio-medicine. In particular, SWOT analysis peptides, relevance therapies diverse diseases, improvements (bio)synthesis platforms, advanced nano-supramolecular technologies, aptamers, altered ligands silico methodologies overcome limitations, modern smart bio-functional materials, vaccines, drug/gene-targeted delivery systems discussed.

Language: Английский

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Peptide-based nanomaterials: Self-assembly, properties and applications

Bioactive Materials, Journal Year: 2021, Volume and Issue: 11, P. 268 - 282

Published: Sept. 28, 2021

Peptide-based materials that have diverse structures and functionalities are an important type of biomaterials. In former times, peptide-based nanomaterials with excellent stability were constructed through self-assembly. Compared individual peptides, self-assembly form well-ordered superstructures possess many advantages such as good thermo- mechanical stability, semiconductivity, piezoelectricity optical properties. Moreover, due to their biocompatibility biological activity, been vastly used in different fields. this review, we provide the advances nanostructures, focusing on driving forces dominate peptide assembly mechanisms peptides. After that, outline synthesis properties nanomaterials, followed by applications functional nanomaterials. Finally, perspectives challenges future

Language: Английский

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Protein Assembly by Design

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(22), P. 13701 - 13796

Published: Aug. 18, 2021

Proteins are nature's primary building blocks for the construction of sophisticated molecular machines and dynamic materials, ranging from protein complexes such as photosystem II nitrogenase that drive biogeochemical cycles to cytoskeletal assemblies muscle fibers motion. Such natural systems have inspired extensive efforts in rational design artificial last two decades. As blocks, proteins highly complex, terms both their three-dimensional structures chemical compositions. To enable control over self-assembly complex molecules, scientists devised many creative strategies by combining tools principles experimental computational biophysics, supramolecular chemistry, inorganic materials science, polymer among others. Owing these innovative strategies, what started a purely structure-building exercise decades ago has, short order, led with unprecedented functions protein-based unusual properties. Our goal this review is give an overview exciting interdisciplinary area research, first outlining been controlling self-assembly, then describing diverse assemblies, finally highlighting emergent properties assemblies.

Language: Английский

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Peptide Design and Self-assembly into Targeted Nanostructure and Functional Materials

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(22), P. 13915 - 13935

Published: Oct. 28, 2021

Peptides have been extensively utilized to construct nanomaterials that display targeted structure through hierarchical assembly. The self-assembly of both rationally designed peptides derived from naturally occurring domains in proteins as well intuitively or computationally form β-sheets and helical secondary structures widely successful constructing nanoscale morphologies with well-defined 1-d, 2-d, 3-d architectures. In this review, we discuss these successes peptide self-assembly, especially the context designing materials. particular, emphasize differences level design an indicator complexity within self-assembled materials highlight future avenues for scientific technological advances field.

Language: Английский

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Chemical syntheses of bioinspired and biomimetic polymers toward biobased materials

Nature Reviews Chemistry, Journal Year: 2021, Volume and Issue: 5(11), P. 753 - 772

Published: Oct. 5, 2021

Language: Английский

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Antimicrobial peptides towards clinical application: Delivery and formulation

Advanced Drug Delivery Reviews, Journal Year: 2021, Volume and Issue: 175, P. 113818 - 113818

Published: June 4, 2021

Language: Английский

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Self-assembled inorganic chiral superstructures

Nature Reviews Chemistry, Journal Year: 2022, Volume and Issue: 6(2), P. 125 - 145

Published: Jan. 17, 2022

Language: Английский

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Designing bioresponsive nanomaterials for intracellular self-assembly

Nature Reviews Chemistry, Journal Year: 2022, Volume and Issue: 6(5), P. 320 - 338

Published: April 1, 2022

Language: Английский

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NBD-based synthetic probes for sensing small molecules and proteins: design, sensing mechanisms and biological applications

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(13), P. 7436 - 7495

Published: Jan. 1, 2021

Compounds with a nitrobenzoxadiazole (NBD) skeleton exhibit high reactivity toward biological nucleophilies accompanied by distinct colorimetric and fluorescent changes, environmental sensitivity, small size, all of which facilitate biomolecular sensing self-assembly.

Language: Английский

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Bioinspired chiral inorganic nanomaterials

Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 1(2), P. 88 - 106

Published: Jan. 27, 2023

From small molecules to entire organisms, evolution has refined biological structures at the nanoscale, microscale and macroscale be chiral—that is, mirror dissymmetric. Chirality results in biological, chemical physical properties that can influenced by circularly polarized electromagnetic fields. Chiral nanoscale materials designed mimic, refine advance chiral geometries, engineer optical, for applications photonics, sensing, catalysis biomedicine. In this Review, we discuss mechanisms underlying chirality transfer nature provide design principles nanomaterials. We highlight how features emerge inorganic during synthesis of nanostructures, outline key nanomaterials, including promising designs biomedical applications, such as biosensing immunomodulation. conclude with an outlook future opportunities challenges, need characterization techniques. nanomaterials induce specific physical, phenomena. This Review discusses biomolecules light allow control which applied optical devices,

Language: Английский

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