Stimuli-activatable nanomedicine meets cancer theranostics

Theranostics, Journal Year: 2023, Volume and Issue: 13(15), P. 5386 - 5417

Published: Jan. 1, 2023

Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics.Upon exposure to endogenous/exogenous stimuli, stimuli-activatable could be self-assembled, disassembled, or functionally activated improve its biosafety and diagnostic/therapeutic potency.A myriad tumor-specific features, including a low pH, high redox level, overexpressed enzymes, along with exogenous physical stimulation sources (light, ultrasound, magnet, radiation) have been considered nano-medicinal products.Recently, novel stimuli explored elegant designs emerged nanomedicine.In addition, multi-functional theranostic has employed imaging-guided image-assisted antitumor therapy.In this review, we rationalize development clinical pressing needs.Stimuli-activatable self-assembly, disassembly functional activation approaches developing realize better efficacy are elaborated state-of-the-art advances their structural detailed.A reflection, status, future perspectives provided.

Language: Английский

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Apoptosis-Amplified Assembly of Porphyrin Nanofiber Enhances Photodynamic Therapy of Oral Tumor

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(14), P. 7918 - 7930

Published: March 29, 2023

Oral squamous cell carcinoma (OSCC) is the most common oral cancer, having high recurrence and metastasis features. In addition to surgery, photodynamic therapy (PDT) considered as another effective approach for OSCC treatment. The water solubility of currently available PDT photosensitizers (PSs) poor, lowering their singlet oxygen (1O2) yield consequent efficiency. Strategies PS assembly have been reported increase 1O2 yield, but it still possible further enhance this work, we utilized apoptosis amplify porphyrin nanofibers enhanced OSCC. A water-soluble derivative, Ac-Asp-Glu-Val-Asp-Asp-TPP (Ac-DEVDD-TPP), was designed purpose. Upon caspase-3 (Casp3, an activated enzyme during apoptosis) cleavage laser irradiation, Ac-DEVDD-TPP converted D-TPP, which spontaneously self-assembled into nanofibers, accompanied by 1.4-fold 2.1-fold generations in vitro cells, respectively. as-formed nanofiber induced efficient pyroptosis. vivo experiments demonstrated that, compared with scrambled control compound Ac-DEDVD-TPP, led 6.2-fold 1.3-fold expressions Casp3 subcutaneous orthotopic tumor models, respectively, significantly suppressed tumors. We envision that our strategy apoptosis-amplified might be applied treatment clinic near future.

Language: Английский

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In situ self-assembly for cancer therapy and imaging

Nature Reviews Materials, Journal Year: 2023, Volume and Issue: 8(11), P. 710 - 725

Published: Aug. 29, 2023

Language: Английский

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Tumor Abnormality-Oriented Nanomedicine Design

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(18), P. 10920 - 10989

Published: Sept. 15, 2023

Anticancer nanomedicines have been proven effective in mitigating the side effects of chemotherapeutic drugs. However, challenges remain augmenting their therapeutic efficacy. Nanomedicines responsive to pathological abnormalities tumor microenvironment (TME) are expected overcome biological limitations conventional nanomedicines, enhance efficacies, and further reduce effects. This Review aims quantitate various TME, which may serve as unique endogenous stimuli for design stimuli-responsive provide a broad objective perspective on current understanding cancer treatment. We dissect typical transport process barriers drug delivery, highlight key principles designed tackle series delivery process, discuss "all-into-one" "one-for-all" strategies integrating needed properties nanomedicines. Ultimately, we insight into future perspectives toward clinical translation

Language: Английский

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One-dimensional nanomaterials for cancer therapy and diagnosis

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(13), P. 4488 - 4514

Published: Jan. 1, 2023

One-dimensional (1-D) nanomaterials possess unique shape-dependent phyicochemical properties and are increasingly recognized as promising materials for nanotechnology. 1-D can be classified according to their shape, such nanorods, nanotubes, nanowires, self-assembled nanochains, etc., have been applied in electronics, photonics, catalysis. The biological characteristics of nanomaterials, including high drug loading efficiency, prolonged blood circulation, the ability capture cancer cells, cellular uptake mechanisms, efficient photothermal conversion, material tunability, aided extending potential biomedical applications, particularly therapy diagnosis. This review highlights a novel perspective on emerging diagnosis by introducing definition physicochemical properties, recent advances also proposes unexplored nanomaterial types therapeutic applications nanomaterials. In particular, most significant exciting years, ultrasound-enabled sonodynamic therapy, magnetic field-based bioresponsive intracellular self-assembly situ, discussed along with concepts, piezoelectric nanozyme-based nanomedicine, others.

Language: Английский

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Photoswitchable coordination cages

Nature Chemistry, Journal Year: 2024, Volume and Issue: 16(1), P. 13 - 21

Published: Jan. 1, 2024

Language: Английский

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Mitochondrial Localized In Situ Self‐Assembly Reprogramming Tumor Immune and Metabolic Microenvironment for Enhanced Cancer Therapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(15)

Published: Jan. 8, 2024

Abstract The inherent immune and metabolic tumor microenvironment (TME) of most solid tumors adversely affect the antitumor efficacy various treatments, which is an urgent issue to be solved in clinical cancer therapy. In this study, a mitochondrial localized situ self‐assembly system constructed remodel TME by improving immunogenicity disrupting plasticity cells. peptide‐based drug delivery can pre‐assembled into nanomicelles vitro form functional nanofibers on mitochondria through cascade‐responsive process involving reductive release, targeted enrichment, self‐assembly. organelle‐specific self‐assemblyeffectively switches role mitophagy from pro‐survival pro‐death, finally induces intense endoplasmic reticulum stress atypical type II immunogenic cell death. Disintegration ultrastructure also impedes cells, greatly promotes immunosuppresive remodeling immunostimulatory TME. Ultimately, effectively suppresses metastases, converts cold hot with enhanced sensitivity radiotherapy checkpoint blockade This study offers universal strategy for spatiotemporally controlling supramolecular sub‐organelles determine fate enhance

Language: Английский

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Transformable Supramolecular Self‐Assembled Peptides for Cascade Self‐Enhanced Ferroptosis Primed Cancer Immunotherapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(21)

Published: Feb. 10, 2024

Abstract Immunotherapy has received widespread attention for its effective and long‐term tumor‐eliminating ability. However, immunogenic “cold” tumors, such as prostate cancer (PCa), the low immunogenicity of tumor itself is a serious obstacle to efficacy. Here, this work reports strategy enhance PCa by triggering cascade self‐enhanced ferroptosis in cells, turning from “hot”. This develops transformable self‐assembled peptide TEP‐FFG‐CRApY with alkaline phosphatase (ALP) responsiveness glutathione peroxidase 4 (GPX4) protein targeting. self‐assembles into nanoparticles under aqueous conditions transforms nanofibers response ALP during endosome/lysosome uptake promoting lysosomal membrane permeabilization (LMP). On one hand, released TEP‐FFG‐CRAY target GPX4 selectively degrade light irradiation, inducing ferroptosis; on other large amount leaked Fe 2+ further amplify through Fenton reaction. TEP‐FFG‐CRApY‐induced improves cell maturation dendritic cells (DCs) increasing intratumor T‐cell infiltration. More importantly, recovered T secreting amounts interferon‐gamma (IFN‐γ). provides novel molecular design synergistic molecularly targeted therapy tumors.

Language: Английский

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Sulfatase-Induced In Situ Formulation of Antineoplastic Supra-PROTACs

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(15), P. 10753 - 10766

Published: April 5, 2024

Proteolysis targeting chimera (PROTAC) technology is an innovative strategy for cancer therapy, which, however, suffers from poor delivery and limited capability protein of interest (POI) degradation. Here, we report a the in situ formulation antineoplastic Supra-PROTACs via intracellular sulfatase-responsive assembly peptides. Coassembling sulfated peptide with two ligands binding to ubiquitin VHL Bcl-xL leads formation pro-Supra-PROTAC, which ratio rationally optimized based on their affinity. The resulting pro-Supra-PROTAC precisely undergoes enzyme-responsive into nanofibrous cells overexpressing sulfatase. Mechanistic studies reveal that pro-Supra-PROTACs selectively cause apparent cytotoxicity through degradation activation caspase-dependent apoptosis, during ligand improves bioactivity POI cell death. In vivo show enhanced tumor accumulation retention pro-Supra-PROTACs, as well inhibiting growth excellent biosafety when coadministrating chemodrugs. Our findings provide new approach enzyme-regulated peptides living development PROTACs high delivering efficiency.

Language: Английский

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Tandem-controlled lysosomal assembly of nanofibres induces pyroptosis for cancer immunotherapy

Nature Nanotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Language: Английский

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