Multifunctional Metal–Phenolic Composites Promote Efficient Periodontitis Treatment via Antibacterial and Osteogenic Properties

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(11), P. 13573 - 13584

Published: March 5, 2024

Periodontitis, a complex inflammatory disease initiated by bacterial infections, presents significant challenge in public health. The increased levels of reactive oxygen species and the subsequent exaggerated immune response associated with periodontitis often lead to alveolar bone resorption tooth loss. Herein, we develop multifunctional metal–phenolic composites (i.e., Au@MPN-BMP2) address nature periodontitis, where gold nanoparticles (AuNPs) are coated networks (MPNs) morphogenetic protein 2 (BMP2). In this design, MPNs exhibit remarkable antibacterial antioxidant properties, AuNPs BMP2 promote osteogenic differentiation marrow mesenchymal stem cells under conditions. rat model treatment Au@MPN-BMP2 leads notable therapeutic outcomes, including mitigated oxidative stress, reduced progression inflammation, prevention These results highlight multifunctionality as promising approach for addressing both microbial causative factors an overactivated response. We envision that rational design will provide versatile nanoplatforms tissue regeneration potential clinical applications.

Language: Английский

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Metal–Phenolic‐Mediated Assembly of Functional Small Molecules into Nanoparticles: Assembly and Bioapplications

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(12)

Published: Jan. 29, 2024

Abstract Small molecules, including therapeutic drugs and tracer play a vital role in biological processing, disease treatment diagnosis, have inspired various nanobiotechnology approaches to realize their function, particularly drug delivery. Desirable features of delivery system for functional small molecules (FSMs) include high biocompatibility, loading capacity, simple manufacturing processes, without the need chemical modification FSM itself. Herein, we report versatile approach, based on metal–phenolic‐mediated assembly, assembling FSMs into nanoparticles (i.e., FSM‐MPN NPs) under aqueous ambient conditions. We demonstrate anticancer drugs, latency reversal agents, fluorophores at up ~80 % that is mostly facilitated by π hydrophobic interactions between nanoparticle components. Secondary engineering involving coating with polyphenol–antibody thin film or sequential co‐loading multiple enables cancer cell targeting combination delivery, respectively. Incorporating NPs visualization biodistribution different time points, revealing most these are retained kidney heart 24 h post intravenous administration. This work provides viable pathway rational design molecule platforms diverse applications.

Language: Английский

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A roadmap of MOFs derived porous carbon, oxides, chalcogenides, and phosphides of metals: Synthesis, properties, parameter modulation and their utilization as an electrode for Li/Na/K-ion batteries

Journal of Energy Storage, Journal Year: 2024, Volume and Issue: 84, P. 110947 - 110947

Published: Feb. 22, 2024

Language: Английский

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Drug carrier wonders: Synthetic strategies of zeolitic imidazolates frameworks (ZIFs) and their applications in drug delivery and anti-cancer activity

Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 329, P. 103184 - 103184

Published: May 17, 2024

Language: Английский

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Modulator-assisted solvent-free synthesis of amorphous zirconium terephthalate catalyst for efficient oxidative desulfurization

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 469, P. 133886 - 133886

Published: Feb. 29, 2024

Language: Английский

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Adsorption of perfluoroalkyl substances on deep eutectic solvent-based amorphous metal-organic framework: Structure and mechanism

Environmental Research, Journal Year: 2024, Volume and Issue: 248, P. 118261 - 118261

Published: Jan. 23, 2024

Language: Английский

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Metal‐Phenolic Nanocloaks on Cancer Cells Potentiate STING Pathway Activation for Synergistic Cancer Immunotherapy

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 136(12)

Published: Feb. 2, 2024

Abstract Due to the presence of natural neoantigens, autologous tumor cells hold great promise as personalized therapeutic vaccines. Yet cell vaccines require multi‐step production that frequently leads loss immunoreactive antigens, causing insufficient immune activation and significantly hampering their clinical applications. Herein, we introduce a novel whole‐cell cancer vaccine by cloaking with lipopolysaccharide‐decorated manganese(II)‐phenolic networks (MnTA nanocloaks) evoke tumor‐specific response for highly efficacious synergistic immunotherapy. The polyphenols coordinate Mn 2+ immediately adhere surface individual cells, thereby forming nanocloak encapsulating neoantigens. Subsequent decoration lipopolysaccharide induces internalization dendritic where ions are released in cytosol, further facilitating stimulator interferon genes (STING) pathway. Highly effective suppression was observed combining nanocloaked treatment anti‐programmed death ligand 1 (anti‐PD‐L1) antibodies‐mediated checkpoint blockade therapy. Our work demonstrates universal yet simple strategy engineer cell‐based nanobiohybrid system enhanced

Language: Английский

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Looking into the future of hybrid glasses

Nature Chemistry, Journal Year: 2024, Volume and Issue: 16(11), P. 1755 - 1766

Published: Oct. 11, 2024

Language: Английский

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Stöber method to amorphous metal-organic frameworks and coordination polymers

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 27, 2024

Abstract The Stöber method is a widely-used sol-gel route for synthesizing amorphous SiO 2 colloids and conformal coatings. However, the material systems compatible with this are still limited. Herein, we have extended approach to metal-organic frameworks (MOFs) coordination polymers (CPs) by mimicking method. We introduce general synthesis MOFs or CPs making use of base-vapor diffusion method, which allows precisely control growth kinetics. Twenty-four different were successfully synthesized selecting 12 metal ions 17 organic ligands. Moreover, introducing functional nanoparticles (NPs), coating controllable thickness can be grown on NPs form core-shell colloids. versatility technology was demonstrated over 100 composites from 20 shells 30 NPs. Besides, various multifunctional nanostructures, such as yolk-amorphous MOF shell, core@metal oxides, core@carbon, obtained through one-step transformation core@amorphous MOFs. This work significantly enriches introduces platform, enabling systematic design exhibiting level functionality complexity.

Language: Английский

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Supramolecular Polymer Frameworks with Controlled and Uniform Pore Apertures

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: June 27, 2024

Porous frameworks with controlled pore structure and tunable aperture are greatly demanded. However, precise synthesis of this kind materials is a formidable challenge. Herein, we report the fabrication two-dimensional (2D) supramolecular polymer using precisely synthesized rod-like helical polyisocyanide as link. Four three-arm star-shaped polyisocyanides degree polymerization 10, 20, 30 40, having 2-ureido-4[1H]-pyrimidinone (UPy) terminals were synthesized. 2D-Crystalline apertures 5.3, 10.1, 13.9, 19.1 nm respectively obtained through intermolecular hydrogen bonding interaction between terminal Upy units. The dependent on length backbone. Thus, well-defined uniform hexagonal pores obtained, proved by small-angle X-ray scattering (synchrotron radiation facility), atomic force microscopy, Brunauer-Emmett-Teller analyses. large used to purify nanomaterials immobilize biomacromolecules. For instance, membranes could size-fractionation silver nanoparticles into very low dispersity. facilitated inclusion myoglobin enhanced stability catalytic activity.

Language: Английский

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