Gut Microbes,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: Jan. 24, 2025
The
interplay
between
the
gut
microbiota
and
gastrointestinal
hormones
plays
a
pivotal
role
in
health
of
host
development
diseases.
As
vital
component
intestinal
microecosystem,
influences
synthesis
release
many
through
mechanisms
such
as
modulating
environment,
producing
metabolites,
impacting
mucosal
barriers,
generating
immune
inflammatory
responses,
releasing
neurotransmitters.
Conversely,
exert
feedback
regulation
on
by
nutrient
absorption
utilization,
bacterial
biological
behavior
composition.
distributions
are
anatomically
intertwined,
close
interactions
crucial
for
maintaining
homeostasis.
Interventions
leveraging
have
been
employed
clinical
management
metabolic
diseases
bowel
diseases,
bariatric
surgery
fecal
transplantation,
offering
promising
targets
treatment
dysbiosis-related
Gut,
Journal Year:
2024,
Volume and Issue:
73(8), P. 1376 - 1387
Published: May 22, 2024
Background
Metabolic
disorders
and
inflammatory
bowel
diseases
(IBD)
have
captured
the
globe
during
Westernisation
of
lifestyle
related
dietary
habits
over
last
decades.
Both
disease
entities
are
characterised
by
complex
heterogeneous
clinical
spectra
linked
to
distinct
symptoms
organ
systems
which,
on
a
first
glimpse,
do
not
many
commonalities
in
practice.
However,
experimental
studies
indicate
common
backbone
mechanisms
metabolic
gut
inflammation,
emerging
evidence
suggests
an
intricate
interplay
between
IBD.
Objective
We
depict
parallels
IBD
diseases,
easily
overlooked
routine.
Design
provide
overview
recent
literature
discuss
implications
morbidity
patients
with
for
researchers,
clinicians
healthcare
providers.
Conclusion
The
Western
diet
microbial
perturbation
serve
as
fuel
inflammation
beyond
gut.
syndrome
increasingly
affect
IBD,
expected
negative
impact
both
risk
complications.
This
concept
implies
that
tackling
obesity
pandemic
exerts
beneficial
effects
health.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 26, 2024
The
brain-gut
axis
plays
a
vital
role
in
connecting
the
cognitive
and
emotional
centers
of
brain
with
intricate
workings
intestines.
An
imbalance
microbiota-mediated
extends
far
beyond
conditions
like
Irritable
Bowel
Syndrome
(IBS)
obesity,
playing
critical
development
progression
various
neurological
disorders,
including
epilepsy,
depression,
Alzheimer’s
disease
(AD),
Parkinson’s
(PD).
Epilepsy,
disorder
characterized
by
unprovoked
seizures,
affects
approximately
50
million
people
worldwide.
Accumulating
evidence
suggests
that
rebuilding
gut
microbiota
through
interventions
such
as
fecal
transplantation,
probiotics,
ketogenic
diets
(KD)
can
benefit
drug-resistant
epilepsy.
disturbances
could
contribute
to
toxic
side
effects
antiepileptic
drugs
drug
resistance
epilepsy
patients.
These
findings
imply
potential
impact
on
suggest
targeting
microbiota,
KD,
hold
promise
for
managing
treating
However,
full
extent
importance
treatment
is
not
yet
fully
understood,
many
aspects
this
field
remain
unclear.
Therefore,
article
aims
provide
an
overview
clinical
animal
supporting
regulatory
pathways
within
may
be
influenced
Furthermore,
we
will
discuss
recent
advancements
treatment,
antiseizure
drugs,
all
from
perspective
microbiota.
Clinical Microbiology Reviews,
Journal Year:
2024,
Volume and Issue:
37(3)
Published: June 28, 2024
SUMMARY
The
gut
microbiota
is
a
major
factor
contributing
to
the
regulation
of
energy
homeostasis
and
has
been
linked
both
excessive
body
weight
accumulation
fat
mass
(i.e.,
overweight,
obesity)
or
loss,
weakness,
muscle
atrophy,
depletion
cachexia).
These
syndromes
are
characterized
by
multiple
metabolic
dysfunctions
including
abnormal
food
reward
intake,
storage,
low-grade
inflammation.
Given
increasing
worldwide
prevalence
obesity,
cachexia,
associated
disorders,
novel
therapeutic
strategies
needed.
Among
different
mechanisms
explaining
how
capable
influencing
host
metabolism
balance,
numerous
studies
have
investigated
complex
interactions
existing
between
nutrition,
microbes,
their
metabolites.
In
this
review,
we
discuss
microbes
microbiota-derived
metabolites
regulate
metabolism.
We
describe
role
barrier
function
in
onset
inflammation
context.
explore
importance
gut-to-brain
axis
glucose
but
also
key
played
liver.
Finally,
present
specific
examples
using
targeted
approaches
such
as
prebiotics
probiotics
might
affect
metabolites,
signaling
pathways,
with
reflect
on
challenges
move
from
bench
bedside.
Gut Microbes,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: Jan. 24, 2025
The
interplay
between
the
gut
microbiota
and
gastrointestinal
hormones
plays
a
pivotal
role
in
health
of
host
development
diseases.
As
vital
component
intestinal
microecosystem,
influences
synthesis
release
many
through
mechanisms
such
as
modulating
environment,
producing
metabolites,
impacting
mucosal
barriers,
generating
immune
inflammatory
responses,
releasing
neurotransmitters.
Conversely,
exert
feedback
regulation
on
by
nutrient
absorption
utilization,
bacterial
biological
behavior
composition.
distributions
are
anatomically
intertwined,
close
interactions
crucial
for
maintaining
homeostasis.
Interventions
leveraging
have
been
employed
clinical
management
metabolic
diseases
bowel
diseases,
bariatric
surgery
fecal
transplantation,
offering
promising
targets
treatment
dysbiosis-related
