Hypothyroidism

Nature Reviews Disease Primers, Journal Year: 2022, Volume and Issue: 8(1)

Published: May 19, 2022

Language: Английский

---

Sleep disorders and cancer: State of the art and future perspectives

Sleep Medicine Reviews, Journal Year: 2020, Volume and Issue: 56, P. 101409 - 101409

Published: Nov. 28, 2020

Language: Английский

---

Food as a circadian time cue — evidence from human studies

Nature Reviews Endocrinology, Journal Year: 2020, Volume and Issue: 16(4), P. 213 - 223

Published: Feb. 13, 2020

Language: Английский

---

The clinical impact of chronopharmacology on current medicine

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract One of the goals clinical pharmacology is to optimize patient treatment by adopting new strategies which will increase efficacy and decrease adverse effects drugs. In literature, it has shown that effectiveness toxicity medications can vary significantly based on when they are administered, making timing a crucial factor in plans. Chronopharmacology relatively branch focuses adjusting drug administration times enhance outcomes. largely influenced an individual’s circadian rhythm refers periodic changes biological processes depending time day. The chronopharmacology influences practice, accumulating knowledge this field likely lead healthcare providers adopt for regimens. This review aims summarize impact particularly current practices highlight latest findings related chronophysiological mechanisms.

Language: Английский

---

Circadian Rhythms, Disease and Chronotherapy

Journal of Biological Rhythms, Journal Year: 2021, Volume and Issue: 36(6), P. 503 - 531

Published: Sept. 22, 2021

Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology and behavior, exemplified by cycles sleep/wake, hormone release, metabolism. The adaptive value is evident when internal body daily environmental mismatched, such as in the case shift work jet lag or even mistimed eating, all which associated with physiological disruption disease. Studies animal human models have also unraveled an important role functional circadian modulating cellular organismal responses to cues (ex., food intake, exercise), pathological insults (e.g. virus parasite infections), medical interventions medication). With growing knowledge molecular underlying pathophysiology, it becoming possible target for disease prevention treatment. In this review, we discuss recent advances research potential therapeutic applications take patient into account treating

Language: Английский

---

Human circadian variations

Journal of Clinical Investigation, Journal Year: 2021, Volume and Issue: 131(16)

Published: Aug. 15, 2021

Circadian rhythms, present in most phyla across life, are biological oscillations occurring on a daily cycle. Since the discovery of their molecular foundations model organisms, many inputs that modify this tightly controlled system humans have been identified. Polygenic variations and environmental factors influence each person's circadian rhythm, contributing to trait known as chronotype, which manifests degree morning or evening preference an individual. Despite normal variation much society operates "one size fits all" schedule can be difficult adjust to, especially for certain individuals whose endogenous phase is extremely advanced delayed. This public health concern, misalignment associated with number adverse outcomes. Additionally, modern technology (such electric lights computer, tablet, phone screens emit blue light) lifestyles shift irregular work schedules) disrupting consistency increasing people. Though medical lifestyle interventions alleviate some these issues, growing research variability sensitivity suggests broader social changes may necessary minimize impact health.

Language: Английский

---

Effects of Intermittent Fasting on the Circulating Levels and Circadian Rhythms of Hormones

Endocrinology and Metabolism, Journal Year: 2021, Volume and Issue: 36(4), P. 745 - 756

Published: Aug. 30, 2021

Intermittent fasting has become an increasingly popular strategy in losing weight and associated reduction obesity-related medical complications. Overwhelming studies support metabolic improvements from intermittent blood glucose levels, cardiac brain function, other health benefits, addition to loss. However, concerns have also been raised on side effects including muscle loss, ketosis, electrolyte imbalance. Of particular concern, the effect of hormonal circadian rhythms received little attention. Given known importance changes normal physiology, potential detrimental by dysregulation deserve careful discussions. In this review, we describe hormones caused fasting. We covered major commonly pathophysiologically involved clinical endocrinology, insulin, thyroid hormones, glucocorticoids. that could alter both level frequency hormone secretion, decisions practicing should take more considerations consequences versus beneficial pertaining individual conditions.

Language: Английский

---

Impact of sleep patterns upon female neuroendocrinology and reproductive outcomes: a comprehensive review

Reproductive Biology and Endocrinology, Journal Year: 2022, Volume and Issue: 20(1)

Published: Jan. 18, 2022

Abstract Sleep is vital to human bodily function. Growing evidence indicates that sleep deprivation, disruption, dysrhythmia, and disorders are associated with impaired reproductive function poor clinical outcomes in women. These associations largely mediated by molecular-genetic hormonal pathways, which crucial for the complex time sensitive processes of hormone synthesis/secretion, folliculogenesis, ovulation, fertilization, implantation, menstruation. Pathologic patterns closely linked menstrual irregularity, polycystic ovarian syndrome, premature insufficiency, sub/infertility, early pregnancy loss. Measures success assisted technology also lower among women who engage shift work, or experience disruption short duration. Extremes duration, quality, disordered breathing, work several harmful conditions pregnancy, including gestational diabetes hypertensive disorders. While accumulating implicates pathologic outcomes, additional research needed determine causality propose therapeutic interventions.

Language: Английский

---

Melatonergic Receptors (Mt1/Mt2) as a Potential Additional Target of Novel Drugs for Depression

Neurochemical Research, Journal Year: 2022, Volume and Issue: 47(10), P. 2909 - 2924

Published: June 11, 2022

Language: Английский

---

Sleep Deprivation and Central Appetite Regulation

Nutrients, Journal Year: 2022, Volume and Issue: 14(24), P. 5196 - 5196

Published: Dec. 7, 2022

Research shows that reduced sleep duration is related to an increased risk of obesity. The relationship between deprivation and obesity, type 2 diabetes, other chronic diseases may be the imbalance appetite regulation. To comprehensively illustrate specific regulation, this review introduces pathophysiology deprivation, research cutting edge animal models, central regulatory mechanism under deprivation. This paper summarizes changes in appetite-related hormones orexin, ghrelin, leptin, insulin secretion caused by long-term based on epidemiology data studies have established models. Moreover, analyzes potential associations regulation providing more clues further new strategies access obesity metabolic disease.

Language: Английский

---