Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

Nature Reviews Endocrinology, Journal Year: 2020, Volume and Issue: 16(7), P. 349 - 362

Published: May 12, 2020

Language: Английский

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Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing

Nutrients, Journal Year: 2021, Volume and Issue: 13(6), P. 1951 - 1951

Published: June 6, 2021

It has been established, worldwide, that non-communicable diseases such as obesity, diabetes, metabolic syndrome, and cardiovascular events account for a high percentage of morbidity mortality in contemporary societies. Several modifiable risk factors, sedentary activities, sleep deprivation, smoking, unhealthy dietary habits have contributed to this increase. Healthy nutrition terms adherence the Mediterranean diet (MD), rich fruits, legumes, vegetables, olive oil, herbs, spices, fiber intake may contribute decrease pandemic. The beneficial effects MD can be mainly attributed its numerous components anti-inflammatory antioxidant properties. Moreover, further improvement reproductive health, modify neurodegenerative diseases, protect against depression psychosocial maladjustment. There is also evidence highlighting impact healthy female people on composition gut microbiota future overall health their offspring. therefore important highlight metabolic, reproductive, mental while shaping generations. enhanced by increased physical activity context well-balanced lifestyle.

Language: Английский

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Cadmium exposure impairs pancreatic β-cell function and exaggerates diabetes by disrupting lipid metabolism

Environment International, Journal Year: 2021, Volume and Issue: 149, P. 106406 - 106406

Published: Jan. 25, 2021

Cadmium is known as an environmental pollutant that contributes to pancreatic damage and the pathogenesis of diabetes. However, less attention has been devoted elucidating mechanisms underlying Cd-induced β-cell dysfunction role Cd toxicity in development In this study, we demonstrated exposure caused remarkable death, both vitro vivo. Lipidomic analysis Cd-exposed β-cells using high-resolution mass spectrometry revealed altered profile abundance lipids. induced intracellular lipid accumulation, promoted biogenesis, elevated pro-inflammatory contents inhibited degradation. Furthermore, upregulated expression levels TNF-α, IL-1β IL-6 IL1-β serum pancreas. Taken together, results our study relevant causes lipids elevation insulin secretion hence exaggerates diabetes development. Combined hazardous chemicals might markedly increase probability developing humans. This provides new metabolic pharmacological targets for antagonizing toxicity.

Language: Английский

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Type 1 diabetes

The Lancet, Journal Year: 2023, Volume and Issue: 401(10394), P. 2149 - 2162

Published: April 6, 2023

Language: Английский

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Progress in the Relationship between Vitamin D Deficiency and the Incidence of Type 1 Diabetes Mellitus in Children

Journal of Diabetes Research, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 8

Published: Sept. 2, 2022

Type 1 diabetes mellitus (T1DM) is an autoimmune disease, due to a large number of islet β cells damaged, resulting in absolute lack insulin, ultimately relying on insulin therapy. Vitamin D fat-soluble sterol derivative that not only participates calcium and phosphorus metabolism but also acts as immunomodulatory role by binding nuclear vitamin receptors regulate the expression transcription factors. Increasing evidence has shown immunoregulation anti-inflammatory effects, it may play T cell regulatory responses downregulation cathepsin G inhibition CD4+ activation protection from immune attack beneficial decreasing oxidative stress T1DM patients. Epidemiologic demonstrates involvement deficiency pathogenesis, with system improperly targeting destroying its own cells. In addition, polymorphisms genes critical for increase risk autoimmunity T1DM. this paper, relationship between molecular mechanism was discussed.

Language: Английский

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Persistent coxsackievirus B infection and pathogenesis of type 1 diabetes mellitus

Nature Reviews Endocrinology, Journal Year: 2022, Volume and Issue: 18(8), P. 503 - 516

Published: June 1, 2022

Language: Английский

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Diabetes mellitus and diabetic foot ulcer: Etiology, biochemical and molecular based treatment strategies via gene and nanotherapy

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 151, P. 113134 - 113134

Published: May 24, 2022

Diabetes mellitus (DM) is a collection of metabolic and pathophysiological disorders manifested with high glucose levels in the blood due to inability β-pancreatic cells secrete an adequate amount insulin or insensitivity towards receptor oxidize glucose. Nevertheless, preceding definition only applicable people who do not have inherited disorders. Suppose person has been diagnosed Type 1 2DM sustains injury treatment damage complicated prolonged. In that case, referred as diabetic foot ulcer (DFU). presence many proliferating macrophages site for extended period causes worsen become wound. this review, scientific information therapeutic management DM/DFU nanomedicine, other related data were collected (Web Science PubMed) from January 2000 2022. Most articles revealed standard drugs are usually prescribed along hypoglycaemic medications. Conversely, such stabilize transporters homeostasis limited period, resulting side effects kidney damage/failure, absorption/gastrointestinal problems, hypoglycemic issues. paper, we review current basic clinical evidence about potential medicinal plants, gene therapy, chemical/green synthesized nanoparticles improving profile, facilitating DM DFU associated complications. Preclinical studies also reported lower plasma molecular targets DFU. Research underway explore nanoparticle-based medications avoid effects. Hence, present intended address challenges, recently recognized factors responsible DFU, their pathophysiology, receptors DM, trend,

Language: Английский

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Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Oct. 26, 2022

Abstract Gut dysbiosis has been linked to type 1 diabetes (T1D); however, microbial capacity in T1D remains unclear. Here, we integratively profiled gut functional and metabolic alterations children with new-onset independent cohorts investigated the underlying mechanisms. In T1D, microbiota was characterized by decreased butyrate production bile acid metabolism increased lipopolysaccharide biosynthesis at species, gene, metabolite levels. The combination of 18 bacterial species fecal metabolites provided excellently discriminatory power for T1D. from induced elevated fasting glucose levels declined insulin sensitivity antibiotic-treated mice. streptozotocin-induced mice, exerted protective destructive effects on islet structure function, respectively. Lipopolysaccharide aggravated pancreatic inflammatory response, while activated Insulin1 Insulin2 gene expression. Our study revealed perturbed traits providing potential avenues microbiome-based prevention intervention

Language: Английский

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The ouroboros of autoimmunity

Nature Immunology, Journal Year: 2024, Volume and Issue: 25(5), P. 743 - 754

Published: May 1, 2024

Language: Английский

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Exosomes derived from mesenchymal stem cells in diabetes and diabetic complications

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(4)

Published: April 17, 2024

Abstract Diabetes, a group of metabolic disorders, constitutes an important global health problem. Diabetes and its complications place heavy financial strain on both patients the healthcare establishment. The lack effective treatments contributes to this pessimistic situation negative outlook. Exosomes released from mesenchymal stromal cells (MSCs) have emerged as most likely new breakthrough advancement in treating diabetes diabetes‐associated complication due capacity intercellular communication, modulating local microenvironment, regulating cellular processes. In present review, we briefly outlined properties MSCs-derived exosomes, provided thorough summary their biological functions potential uses related complications.

Language: Английский

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