BMC Geriatrics,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: April 22, 2024
Abstract
Background
The
relationship
between
triglyceride
glucose-body
mass
index
(TyG-BMI)
and
mortality
in
elderly
patients
with
diabetes
mellitus
(DM)
are
still
unclear.
This
study
aimed
to
investigate
the
association
TyG-BMI
all-cause
cardiovascular
among
DM
United
States
(US).
Methods
Patients
aged
over
60
years
from
National
Health
Nutrition
Examination
Survey
(2007–2016)
were
included
this
study.
endpoints
morality
data
extracted
Death
Index
(NDI)
which
records
up
December
31,
2019.
Multivariate
Cox
proportional
hazards
regression
model
was
used
explore
mortality.
Restricted
cubic
spline
nonlinear
relationships.
Results
A
total
of
1363
diabetic
included,
categorized
into
four
quartiles.
mean
age
70.0
±
6.8
years,
48.6%
them
female.
Overall,
there
429
deaths
123
recorded
during
a
median
follow-up
77.3
months.
analyses
indicated
that
compared
1st
quartile
(used
as
reference),
3rd
demonstrated
significant
(model
2:
HR
=
0.64,
95%
CI
0.46–0.89,
P
0.009;
3:
0.65,
0.43–0.96,
0.030).
Additionally,
4th
significantly
associated
1.83,
1.01–3.30,
0.047;
2.45,
1.07–5.57,
0.033).
restricted
revealed
U-shaped
linear
mortality,
after
adjustment
for
possible
confounding
factors.
Conclusions
observed
US
population.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
159, P. 114252 - 114252
Published: Jan. 13, 2023
Diabetic
nephropathy
(DN)
is
one
of
the
most
severe
complications
diabetes.
However,
due
to
its
complex
pathological
mechanisms,
no
effective
therapeutic
methods
(other
than
ACEIs
and
ARBs)
have
been
applied,
which
used
for
many
years
in
clinical
practice.
Recent
studies
shown
that
emerging
therapeutics,
including
novel
target-based
pharmacotherapy,
cell
therapies,
dietary
regulation,
are
leading
new
hopes
DN
management.
This
review
aims
shed
light
on
treatment
by
describing
important
mechanisms
analysing
recent
advances
treatment,
drug
therapy,
regulation.
In
RAAS
activation,
AGE
accumulation,
EMT
involved
inflammation,
cellular
stress,
apoptosis,
pyroptosis,
autophagy.
several
SGLT2
inhibitors,
GLP-1
agonists,
MRAs,
receiving
public
attention.
addition,
stem
therapies
regulation
also
being
emphasized.
Herein,
we
highlight
importance
combining
therapy
anticipate
more
basic
research
or
trials
verify
strategies.
Bioactive Materials,
Journal Year:
2023,
Volume and Issue:
24, P. 463 - 476
Published: Jan. 6, 2023
Diabetes
mellitus,
an
epidemic
with
a
rapidly
increasing
number
of
patients,
always
leads
to
delayed
wound
healing
associated
consistent
pro-inflammatory
M1
polarization,
decreased
angiogenesis
and
increased
reactive
oxygen
species
(ROS)
in
the
microenvironment.
Herein,
poly
(lactic-co-glycolic
acid)
(PLGA)-based
microneedle
patch
loaded
magnesium
hydride
(MgH2)
(MN-MgH2)
is
manufactured
for
defeating
diabetic
wounds.
The
application
contributes
transdermal
delivery
prolonged
release
MgH2
that
can
generate
hydrogen
(H2)
ions
(Mg2+)
after
reaction
body
fluids.
released
H2
reduces
production
ROS,
transforming
pathological
microenvironment
induced
by
diabetes
mellitus.
Meanwhile,
Mg2+
promotes
polarization
pro-healing
M2
macrophages.
Consequently,
cell
proliferation
migration
are
improved,
tissue
regeneration
enhanced.
Such
intelligent
provides
novel
way
accelerating
through
steadily
preserving
releasing
locally
sustainably.
Frontiers in Public Health,
Journal Year:
2023,
Volume and Issue:
11
Published: Oct. 13, 2023
Aging
is
a
progressive
and
irreversible
pathophysiological
process
that
manifests
as
the
decline
in
tissue
cellular
functions,
along
with
significant
increase
risk
of
various
aging-related
diseases,
including
metabolic
diseases.
While
advances
modern
medicine
have
significantly
promoted
human
health
extended
lifespan,
diseases
such
obesity
type
2
diabetes
among
older
adults
pose
major
challenge
to
global
public
societies
age.
Therefore,
understanding
complex
interaction
between
factors
crucial
for
promoting
well-being
healthy
aging.
This
review
article
explores
environmental
behavioral
associated
their
impact
on
The
environment,
an
obesogenic
environment
exposure
toxins,
strongly
correlated
rising
prevalence
its
comorbidities.
Behavioral
factors,
diet,
physical
activity,
smoking,
alcohol
consumption,
sleep
patterns,
influence
throughout
Public
interventions
targeting
modifiable
can
effectively
promote
healthier
lifestyles
prevent
Collaboration
government
agencies,
healthcare
providers
community
organizations
essential
implementing
these
creating
supportive
environments
foster
International Journal of Science and Research Archive,
Journal Year:
2024,
Volume and Issue:
11(1), P. 383 - 395
Published: Jan. 20, 2024
This
comprehensive
review
examines
the
intricate
relationship
between
demographic
shifts,
specifically
aging
of
populations,
and
systemic
challenges
faced
by
healthcare
systems
globally.
As
societies
experience
a
significant
increase
in
life
expectancy
decline
birth
rates,
proportion
elderly
individuals
within
population
is
on
rise.
transformation
poses
multifaceted
to
systems,
necessitating
thorough
exploration
its
implications.
The
first
delves
into
presenting
nuanced
analysis
factors
contributing
populations.
Exploring
advancements
healthcare,
lifestyle
changes,
socio-economic
factors,
paper
establishes
foundation
for
understanding
dynamics
driving
this
global
phenomenon.
Subsequently,
focus
shifts
towards
sector,
elucidating
manifold
arising
from
demographic.
With
surge
chronic
diseases
age-related
conditions,
are
confronted
with
increased
demand
specialized
long-term
care.
has
far-reaching
implications
resource
allocation,
workforce
planning,
overall
sustainability
infrastructures.
also
highlights
importance
addressing
psychological
social
dimensions
aging,
emphasizing
need
holistic
approaches
that
go
beyond
traditional
medical
paradigms.
Societal
attitudes,
stigma,
provision
adequate
support
become
crucial
considerations
achieving
patient-centered
care
elderly.
In
conclusion,
underscores
urgency
adapt
particularly
posed
It
advocates
proactive
approach,
calling
policy
interventions,
innovative
models,
re-evaluation
societal
perspectives
aging.
By
navigating
complexities
inherent
transitions,
can
strive
inclusivity,
sustainability,
improved
quality
growing
population.
Cell Death and Disease,
Journal Year:
2024,
Volume and Issue:
15(4)
Published: April 17, 2024
Abstract
Diabetes,
a
group
of
metabolic
disorders,
constitutes
an
important
global
health
problem.
Diabetes
and
its
complications
place
heavy
financial
strain
on
both
patients
the
healthcare
establishment.
The
lack
effective
treatments
contributes
to
this
pessimistic
situation
negative
outlook.
Exosomes
released
from
mesenchymal
stromal
cells
(MSCs)
have
emerged
as
most
likely
new
breakthrough
advancement
in
treating
diabetes
diabetes‐associated
complication
due
capacity
intercellular
communication,
modulating
local
microenvironment,
regulating
cellular
processes.
In
present
review,
we
briefly
outlined
properties
MSCs-derived
exosomes,
provided
thorough
summary
their
biological
functions
potential
uses
related
complications.
Nanoscale,
Journal Year:
2022,
Volume and Issue:
14(36), P. 12967 - 12983
Published: Jan. 1, 2022
Diabetic
wound
infection
is
a
common
disease
that
has
significantly
reduced
people's
quality
of
life.
Although
tremendous
achievements
have
been
made
in
clinical
treatment,
the
crucial
challenge
diabetic
infected
management
stems
from
detrimental
environment
and
emergence
bacterial
resistance
after
long-term
medication,
which
result
efficacy,
an
increased
dosage
severe
side
effects.
To
tackle
these
issues,
it
great
significance
to
develop
innovative
treatment
strategy
for
therapy.
Currently,
exploitation
nanobiomaterial-based
therapeutic
systems
wounds
booming,
with
stimuli-responsive
performance
received
extensive
attention.
These
are
able
accelerate
healing
due
on-demand
release
agents
response
stimulating
factors.
Based
on
characteristics
wounds,
many
endogenous
(e.g.,
glucose,
enzyme,
hypoxia,
acidity)
employed
targeted
patients.
Additionally,
exogenous
stimulants,
including
light,
magnetism,
temperature,
also
capable
achieving
drug
activation.
In
this
review,
presented,
then
exogenous/endogenous
stimuli
summarized.
Finally,
current
challenges
future
outlook
discussed.
International Journal of Environmental Research and Public Health,
Journal Year:
2022,
Volume and Issue:
19(14), P. 8677 - 8677
Published: July 16, 2022
The
life
expectancy
of
the
population
is
increasing
worldwide
due
to
improvements
in
prevention,
diagnosis,
and
treatment
diseases.
This
favors
a
higher
prevalence
type
2
diabetes
mellitus
(T2DM)
elderly.
Sarcopenia
frailty
are
also
frequently
present
aging.
These
three
entities
share
common
mechanisms
such
as
insulin
resistance,
chronic
inflammation,
mitochondrial
dysfunction.
coexistence
these
situations
worsens
prognosis
elderly
patients.
In
this
paper,
we
review
main
measures
for
prevention
management
sarcopenia
and/or
patients
with
T2DM.
