Human Milk Microbiota Across Lactation Stages and Free Glutamate Concentrations in Healthy Ecuadorian Women DOI Open Access
Manuel E. Baldeón, Paúl Cárdenas, Valentina Arévalo

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 805 - 805

Published: Feb. 26, 2025

Background/Objectives: There is limited information on human milk (HM) microbiome composition and function in Latin America. Also, interactions between HM constituents its have received partial attention. Objective: To characterize the microbiota considering lactation stages (colostrum, transition, mature HM) free glutamate concentrations Ecuadorian mothers. Methods: We recruited 20 mothers that gave birth to normal full-term babies donated colostrum, milk. Samples were assessed by 16S rRNA gene sequencing Oxford Nanopore Technologies (ONT). Free measured proton nuclear magnetic resonance (NMR) spectroscopy. Results: For each stage order of frequency, majority ASVs assigned Staphylococcus, Streptococcus, (Firmicutes); Escherichia, Acinetobacter, (Proteobacteria); Corynebacterium, Lactobacillus, Cutibacterium, (Actinobacteriota); Chryseobacterium, Flavobacterium (Bacteroidota). Alfa diversity was similar samples tended be higher intended for male infants. observed significant differences qualitative β-diversity metrics with low high concentrations. Functional predictions demonstrated presence polyamine biosynthesis II super pathway Conclusions: The core bacterial components women those reported from different parts world, variations at genus level. dynamics need studied maternal production metabolism better understand optimal infant nutrition.

Language: Английский

The intersection of the nervous system and breast cancer DOI
Yutong Liu,

Shiqi Yin,

Guanyu Lu

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 598, P. 217132 - 217132

Published: July 24, 2024

Language: Английский

Citations

12
Endocrine effects of heat exposure and relevance to climate change DOI
Fadil Hannan, Melvin Khee‐Shing Leow, Jason Lee

et al.

Nature Reviews Endocrinology, Journal Year: 2024, Volume and Issue: 20(11), P. 673 - 684

Published: July 30, 2024

Language: Английский

Citations

11
Current Insights in Prolactin Signaling and Ovulatory Function DOI Open Access
Dariusz Szukiewicz

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 1976 - 1976

Published: Feb. 6, 2024

Prolactin (PRL) is a pleiotropic hormone released from lactotrophic cells of the anterior pituitary gland that also originates extrapituitary sources and plays an important role in regulating lactation mammals, as well other actions. Acting endocrine paracrine/autocrine manner, PRL regulates hypothalamic-pituitary-ovarian axis, thus influencing maturation ovarian follicles ovulation. This review provides detailed discussion current knowledge on context ovulation ovulatory disorders, particularly with regard to hyperprolactinemia, which one most common causes infertility women. Much attention has been given structure receptor (PRLR), diverse functions PRLR signaling under normal pathological conditions. The hormonal regulation menstrual cycle connection folliculogenesis ovulation, classifications are described. Finally, state regarding importance TIDA (tuberoinfundibular dopamine), KNDγ (kisspeptin/neurokinin B/dynorphin), GnRH (gonadotropin-releasing hormone) neurons PRL- kisspeptin (KP)-dependent hypothalamic-pituitary-gonadal (HPG) axis women reviewed. Based this review, rationale for pathways therapeutic activities accompanying disorders presented.

Language: Английский

Citations

10
Per- and Polyfluoroalkyl Substances and Breastfeeding as a Vulnerable Function: A Systematic Review of Epidemiological Studies DOI Creative Commons
Clara Amalie Gade Timmermann, Oyemwenosa N. Avenbuan, Megan E. Romano

et al.

Toxics, Journal Year: 2023, Volume and Issue: 11(4), P. 325 - 325

Published: March 29, 2023

Milk formation in the breast during breastfeeding is a complex hormonally regulated process, potentially sensitive to effects of endocrine-disrupting chemical exposures. The environmental chemicals, per- and polyfluoroalkyl substances (PFAS) are known endocrine disruptors. PFAS exposure have been associated with insufficient mammary gland development mice reduced duration humans. aim this review was gather epidemiological evidence on association between duration. Using PubMed Embase, we performed systematic literature search (on 23 January 2023) identify studies examining maternal Animal studies, reviews, non-English were excluded. risk bias assessed using non-randomized exposures tool. Estimates describing identified, data synthesized separately for each type exclusive total breastfeeding. Six 336 2374 participants identified. serum samples (five studies) or based residential address (one study). Five out six found shorter higher exposure. most consistent associations seen perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic (PFNA). finding potential causal agreement findings from experimental studies.

Language: Английский

Citations

22
Parental factors that impact the ecology of human mammary development, milk secretion, and milk composition—a report from “Breastmilk Ecology: Genesis of Infant Nutrition (BEGIN)” Working Group 1 DOI Creative Commons
Margaret Neville, Ellen W. Demerath, Jennifer Hahn‐Holbrook

et al.

American Journal of Clinical Nutrition, Journal Year: 2023, Volume and Issue: 117, P. S11 - S27

Published: May 1, 2023

The goal of Working Group 1 in the Breastmilk Ecology: Genesis Infant Nutrition (BEGIN) Project was to outline factors influencing biological processes governing human milk secretion and evaluate our current knowledge these processes. Many regulate mammary gland development utero, during puberty, pregnancy, through secretory activation, at weaning. These include breast anatomy, vasculature, diet, lactating parent's hormonal milieu including estrogen, progesterone, placental lactogen, cortisol, prolactin, growth hormone. We examine effects time day postpartum interval on secretion, along with role mechanisms parent-infant interactions bonding, particular attention actions oxytocin pleasure systems brain. then consider potential clinical conditions infection, pre-eclampsia, preterm birth, cardiovascular health, inflammatory states, mastitis, particularly, gestational diabetes obesity. Although we know a great deal about transporter by which zinc calcium pass from blood stream into milk, cellular localization transporters that carry substrates such as glucose, amino acids, copper, many other trace metals present across plasma intracellular membranes require more research. pose question how cultured alveolar cells animal models can help answer lingering questions regulation secretion. raise parent infant microbiome immune system development, molecules protection pathogens. Finally, effect medications, recreational illicit drugs, pesticides, endocrine-disrupting chemicals composition, emphasizing this area needs much research attention.

Language: Английский

Citations

22
Metabolic and feeding adjustments during pregnancy DOI
Roberta Haddad-Tóvolli, Marc Claret

Nature Reviews Endocrinology, Journal Year: 2023, Volume and Issue: 19(10), P. 564 - 580

Published: July 31, 2023

Language: Английский

Citations

20
Causes of Low Milk Supply: The Roles of Estrogens, Progesterone, and Related External Factors DOI Creative Commons
Xuehua Jin, Sharon L. Perrella, Ching Tat Lai

et al.

Advances in Nutrition, Journal Year: 2023, Volume and Issue: 15(1), P. 100129 - 100129

Published: Oct. 11, 2023

Low milk supply (LMS) poses a significant challenge to exclusive and continued breastfeeding, affecting approximately 10-15% of mothers. Milk production is intricately regulated by both endocrine autocrine control mechanisms, with oestrogens progesterone playing pivotal roles in this process. In addition endogenously produced hormones, external substances capable interfering normal hormonal actions, including phytoestrogens, mycoestrogens, synthetic oestrogens, contraceptives, can influence production. The effects these extrinsic hormones on may vary based maternal body mass index. This comprehensive review examines the multifaceted causes LMS, focusing involvement progesterone, related factors Furthermore, it investigates interplay between obesity, aiming elucidate mechanisms underlying obesity-associated LMS. Insights from provide valuable perspectives for developing interventions improve address challenges associated

Language: Английский

Citations

17
Soybean Isoflavones Ameliorates Lactation Performance in Postpartum Mice by Alleviating Oxidative Stress and Regulating Gut Microflora DOI
Yuexin Shao,

Yan Yu,

Shilong Pang

et al.

Molecular Nutrition & Food Research, Journal Year: 2024, Volume and Issue: 68(4)

Published: Jan. 4, 2024

Postpartum dysgalactiae syndrome (PPDS) is one of the key issues affecting breastfeeding, usually occurring as breast swelling, a low milk yield, and at length stop secretion. Therefore, there need to investigate effectiveness Traditional Chinese Medicine (TCM) diet therapy in treating or preventing PPDS. This study aims analyze effect soybean isoflavone (SIF), natural estrogen found plants, on postpartum lactation performance mice evaluate its potential treatment for Adult female BALB/c 8 weeks age (25 ± 3 g) are randomly divided into four groups fed with different levels SIF normal 14 days. (0, 50, 100, 200 mg kg-1 BW) provided via intra-gastric route experimental mice. Using high-throughput sequencing microbial diversity mammary gland metabolites, it that SIF-treated potentially show an improved enhanced antioxidant capacity altered gut microbiota. from plant sources high dosage promotes

Language: Английский

Citations

6
Migraines in Women: A Focus on Reproductive Events and Hormonal Milestones DOI Creative Commons
Seong Hoon Kim,

Jeong Wook Park

Deleted Journal, Journal Year: 2024, Volume and Issue: 25(1), P. 3 - 15

Published: April 5, 2024

Migraine, a prevalent neurological disorder, is more common in women than men. This sex difference pronounced after menarche and diminishes menopause. Migraines are influenced by the menstrual cycle, pregnancy, lactation, suggesting connection to hormones, known as estrogen withdrawal theory. Beyond endogenous hormonal changes accompanying reproductive events, exogenous factors such contraceptives or hormone replacement therapy may also affect migraines. The influence cannot be explained simply serum levels; instead, it involves complex interplay of various factors. Here, we delineate aspects migraines associated with over course woman’s life, exploring mechanisms contributing through which hormones

Language: Английский

Citations

6
Proteomics and Peptidomics As a Tool to Compare the Proteins and Endogenous Peptides in Human, Cow, and Donkey Milk DOI
Jianting Ning, Mei Yang, Wanting Liu

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(44), P. 16435 - 16451

Published: Oct. 26, 2023

Cow's milk is the most widely used ingredient in infant formulas. However, its specific protein composition can cause allergic reactions. Finding alternatives to replace cow's and fill nutritional gap with human essential for health of infants. Proteomic peptidomic techniques have supported elucidation milk's ingredients. Recently, omics approaches attracted increasing interest investigation because their high throughput, precision, sensitivity, reproducibility. This review offers a significant overview recent developments proteomics peptidomics study differences human, cow, donkey milk. All three types milks were identified critical biological functions health, particularly Donkey proteins closer milk, less likely reactions, may be developed as novel raw materials formula powders.

Language: Английский

Citations

15