Journal of Advanced Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 1, 2024
Dysbiosis
of
the
gut
microbiota
is
emerging
as
a
pivotal
factor
in
pathogenesis
colorectal
cancer
(CRC).
Ginsenoside
Rh4
(Rh4)
an
active
compound
isolated
from
ginseng
with
beneficial
effects
modulating
intestinal
inflammation
and
dysbiosis,
but
how
regulates
to
alleviate
CRC
remains
underexplored.
We
investigated
impact
on
mechanism
its
action
inhibiting
via
modulation
microbiota.
used
AOM/DSS
model
employed
transcriptomics,
genomics
metabolomics
techniques
explore
inhibitory
CRC.
Furthermore,
we
experiments
involving
antibiotic
treatment
fecal
transplantation
(FMT)
investigate
role
Finally,
elucidated
key
functional
bacteria
metabolites
regulated
by
Our
research
findings
indicated
that
repaired
barrier
damage
caused
CRC,
alleviated
inflammation,
inhibited
development
Additionally,
microbiota-dependent
manner.
increased
diversity
microbiota,
enriched
probiotic
Akkermansia
muciniphila
(A.
muciniphila),
dysbiosis
Subsequently,
A.
muciniphila-mediated
bile
acid
metabolism.
promoted
production
UDCA
enhancing
activity
7α-hydroxysteroid
dehydrogenase
(7α-HSDH).
further
activated
FXR,
modulated
TLR4-NF-κB
signaling
pathway,
thus
results
confirm
inhibits
manner
microbiota-mediated
metabolism
promoting
UDCA,
which
activates
FXR
receptor
pathway.
has
potential
be
modulator
for
preventing
Nutrients,
Journal Year:
2022,
Volume and Issue:
14(21), P. 4475 - 4475
Published: Oct. 25, 2022
Weaning
stress
induces
intestinal
barrier
dysfunction
and
immune
dysregulation
in
mammals.
Various
interventions
based
on
the
modulation
of
microbiota
have
been
proposed.
Our
study
aims
to
explore
effects
co-cultures
from
Lactobacillus
acidophilus
Bacillus
subtilis
(FAM®)
mucosal
perspective
metabolic
function
gut
microbiota.
A
total
180
piglets
were
allocated
three
groups,
i.e.,
a
control
group
(C,
basal
diet),
FAM
(F,
diet
supplemented
with
0.1%
FAM),
an
antibiotic
(A,
mixtures).
Here,
we
showed
supplementation
significantly
increased
body
weight
reduced
diarrhea
incidence,
accompanied
by
attenuated
damage,
levels
tight
junction
proteins,
serum
diamine
oxidase
(DAO)
antimicrobial
peptides.
In
addition,
16S
rRNA
sequencing
metabolomic
analysis
revealed
increase
relative
abundance
Clostridiales,
Ruminococcaceae,
Firmicutes
Muribaculaceae
significant
short-chain
fatty
acids
(SCFAs)
butyric
acid
FAM-treated
piglets.
also
CD4+
T
cells
SIgA+
mucosa
SIgA
production
colon
contents.
Furthermore,
upregulated
expression
IL-22,
receptors
GPR43
GPR41,
aryl
hydrocarbon
receptor
(AhR),
hypoxia-inducible
factor
1α
(HIF-1α).
shows
great
application
prospect
health
provides
reference
for
infant
weaning.
Gut,
Journal Year:
2023,
Volume and Issue:
73(2), P. 350 - 360
Published: Nov. 10, 2023
The
gut
virome
is
a
dense
community
of
viruses
inhabiting
the
gastrointestinal
tract
and
an
integral
part
microbiota.
coexists
with
other
components
microbiota
host
in
dynamic
equilibrium,
serving
as
key
contributor
to
maintenance
intestinal
homeostasis
functions.
However,
this
equilibrium
can
be
interrupted
certain
pathological
states,
including
inflammatory
bowel
disease,
causing
dysbiosis
that
may
participate
disease
pathogenesis.
Nevertheless,
whether
causal
or
bystander
event
requires
further
clarification.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(14)
Published: Dec. 13, 2023
The
treatment
outcomes
of
oral
medications
against
ulcerative
colitis
(UC)
have
long
been
restricted
by
low
drug
accumulation
in
the
mucosa
and
subsequent
unsatisfactory
therapeutic
efficacy.
Here,
high-performance
pluronic
F127
(P127)-modified
gold
shell
(AuS)-polymeric
core
nanotherapeutics
loading
with
curcumin
(CUR)
is
constructed.
Under
near-infrared
irradiation,
resultant
P127-AuS@CURs
generate
transient
mild
photothermia
(TMP;
≈42
°C,
10
min),
which
facilitates
their
penetration
through
colonic
mucus
favors
multiple
cellular
processes,
including
cell
internalization,
lysosomal
escape,
controlled
CUR
release.
This
strategy
relieves
intracellular
oxidative
stress,
improves
wound
healing,
reduces
immune
responses
polarizing
proinflammatory
M1-type
macrophages
to
anti-inflammatory
M2-type.
Upon
administration
hydrogel-encapsulating
plus
intestinal
intralumen
TMP,
effects
acute
chronic
UC
are
demonstrated
be
superior
those
a
widely
used
clinical
drug,
dexamethasone.
(+
TMP)
elevates
proportions
beneficial
bacteria
(e.g.,
Lactobacillus
Lachnospiraceae),
whose
metabolites
can
also
mitigate
symptoms
regulating
genes
associated
antioxidation,
anti-inflammation,
healing.
Overall,
TMP
offers
promising
approach
enhance
noninvasive
medicines
UC.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(9), P. 1280 - 1280
Published: April 25, 2024
Ulcerative
colitis
(UC)
is
characterized
by
chronic
inflammation
and
ulceration
of
the
intestinal
inner
lining,
resulting
in
various
symptoms.
Sea
buckthorn
berries
contain
a
bioactive
compound
known
as
sea
polysaccharide
(SBP).
However,
precise
mechanisms
underlying
impact
SBP
on
UC
remain
unclear.
In
this
study,
we
investigated
effects
pretreatment
with
induced
DSS.
Our
findings
demonstrate
that
effectively
reduces
inflammation,
oxidative
stress,
barrier
damage
associated
colitis.
To
further
elucidate
role
SBP-modulated
gut
microbiota
UC,
performed
fecal
transplantation
(FMT)
DSS-treated
mice.
The
from
SBP-treated
mice
exhibits
notable
anti-inflammatory
antioxidant
effects,
improves
colonic
integrity,
increases
abundance
beneficial
bacteria,
well
enhancing
SCFA
production.
Collectively,
these
results
strongly
indicate
SBP-mediated
amelioration
attributed
to
its
microbiota,
particularly
through
promotion
SCFA-producing
bacteria
subsequent
elevation
levels.
This
study
provides
compelling
evidence
supporting
efficacy
pre-emptive
supplementation
alleviating
symptoms
modulating
thereby
offering
novel
insights
into
potential
regulator
for
relief.
