Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105736 - 105736
Published: Dec. 1, 2024
Language: Английский
Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)
Published: Jan. 25, 2024
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide, and emerging evidence suggests that the gut microbiota may play role in its development progression. In this study, association between B. thetaiotaomicron, species, HCC recurrence, as well patient clinical outcomes, was investigated. It observed thetaiotaomicron-derived acetic acid has potential to modulate polarization pro-pro-inflammatory macrophagess, which promotes function cytotoxic CD8+ T cells. The increased biosynthesis fatty acids implicated modulation pro-inflammatory macrophages by acid. Furthermore, found facilitate transcription ACC1, key enzyme involved biosynthesis, through histone acetylation modification ACC1 promoter region. Curcumin, an inhibitor, significantly blocked inhibitory effects thetaiotaomicron on tumor growth. These findings highlight microbiota-derived recurrence suggest complex interplay microbiota, immune modulation, metabolism, epigenetic regulation context development. Further research area provide insights into novel strategies for prevention treatment targeting metabolites.
Language: Английский
Citations
15
Cell Host & Microbe, Journal Year: 2024, Volume and Issue: 32(8), P. 1301 - 1314.e9
Published: July 11, 2024
Language: Английский
Citations
13
Microbiological Research, Journal Year: 2024, Volume and Issue: 282, P. 127660 - 127660
Published: Feb. 28, 2024
Language: Английский
Citations
12
Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)
Published: July 24, 2024
Commensal microorganisms in the human gut produce numerous metabolites by using small molecules derived from host or diet as precursors. Host dietary lipid are involved energy metabolism and maintaining structural integrity of cell membranes. Notably, microbes can convert these lipids into bioactive signaling through their biotransformation synthesis pathways. These microbiota-derived affect physiology influencing body's immune metabolic processes. This review aims to summarize recent advances microbial transformation immunomodulatory functions metabolites, with a special focus on fatty acids steroids produced our microbiota.
Language: Английский
Citations
10
Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12
Published: April 3, 2025
Obesity is a major healthcare problem worldwide and induced by excess energy intake, resulting in gut microbial composition diversity changes. Through fermentation of dietary fibers, short-chain fatty acids (SCFAs) act as host sources signaling molecules via G protein-coupled receptors such GPR41. Acidipropionibacterium acidipropionici widely used many applications; however, vivo studies on the beneficial effect A. propionate production homeostasis are unclear. Therefore, this study aimed to investigate metabolic effects focusing GPR41 high-fat diet (HFD)-induced obesity mouse model. Here, we demonstrated that OB7439 improved metabolism HFD-induced mice. The intake obese mice increasing production, regulating glucose tolerance, inhibiting hepatic inflammation signaling. Our findings shed light potential using an SCFA producer for prevention treatment disorders. Based these results, suggest may be therapeutic bacterium inhibits modulates community.
Language: Английский
Citations
1
Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2024, Volume and Issue: 23(5)
Published: Aug. 21, 2024
Human milk oligosaccharides (HMOs) are an evolutionarily significant advantage bestowed by mothers for facilitating the development of infant's gut microbiota. They can avoid absorption in stomach and small intestine, reaching colon successfully, where they engage close interactions with microbes. This process also enables HMOs to exert additional prebiotic effects, including regulating mucus layer, promoting physical growth brain development, as well preventing mitigating conditions such NEC, allergies, diarrhea. Here, we comprehensively review primary ways which microbiota, Bifidobacteria other genera, utilize HMOs, classify them into five central pathways. Furthermore, emphasize metabolic benefits bacteria consuming particularly recently identified intrinsic link between conversion tryptophan indole its derivatives. We examine extensive probiotic roles their recent research advancements, specifically concentrating on unsummarized role interaction microbiota becomes crucial. Additionally, delve principal tools used functional mining new HMOs. In conclusion, our study presents a thorough analysis mechanism emphasizing cooperative utilization provides overview subsequent effects this interaction. insights will inform mechanisms function.
Language: Английский
Citations
7
Clinical and Translational Medicine, Journal Year: 2024, Volume and Issue: 14(11)
Published: Nov. 1, 2024
Abstract The profound impact of the microbiota on initiation and progression cancer has been a focus attention. In recent years, many studies have shown that microbial metabolites serve as key hubs connect microbiome progression, but underlying molecular mechanisms not fully elucidated. Multiple influence tumour development therapy resistance, including disrupting cellular signalling pathways, triggering oxidative stress, inducing metabolic reprogramming reshaping immune microenvironment, are reviewed. Focusing advancements in this field, review also summarises methodological framework regarding metabolites. review, we outline current state research tumour‐associated describe challenges future scientific clinical applications. Key points Metabolites derived from both gut intratumoural play important roles progression. dual pose an obstacle for translations. Absolute quantification tracing techniques essential addressing gaps Integrating metabolomics with multi‐omics transcends paradigms.
Language: Английский
Citations
4
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142363 - 142363
Published: March 1, 2025
Language: Английский
Citations
0
Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 354, P. 123300 - 123300
Published: Jan. 20, 2025
Language: Английский
Citations
0
Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)
Published: Feb. 6, 2025
The gut microbiome is altered after bariatric surgery and associated with weight loss. However, the commensal bacteria involved underlying mechanism remain to be determined. We performed shotgun metagenomic sequencing in obese subjects before longitudinally sleeve gastrectomy (SG), found a significant enrichment microbial species Clostridia bile acid metabolizing genes SG treatment. Bile profiling further revealed decreased primary acids (PBAs) increased conjugated secondary (C-SBAs) SG. Specifically, glycodeoxycholic (GDCA) taurodeoxycholic (TDCA) were at different follow-ups SG, abundance of body reduction. Fecal transplantation post-SG feces SBA levels, alleviated gain recipient mice. Furthermore, both Clostridia-enriched spore-forming GDCA supplementation expression responsible for lipolysis fatty oxidation adipose tissue reduced adiposity via Takeda G-protein-coupled receptor 5 (TGR5) signaling. Our findings reveal C-SBAs as contributory SG-induced loss, part TGR5 signaling, suggest SBA-producing microbes potential therapeutic target obesity intervention.
Language: Английский
Citations
0