Hypertension Research, Journal Year: 2024, Volume and Issue: 47(12), P. 3356 - 3362
Published: Aug. 16, 2024
Language: Английский
Circulation Research, Journal Year: 2024, Volume and Issue: 134(6), P. 675 - 694
Published: March 14, 2024
The impact of circadian rhythms on cardiovascular function and disease development is well established, with numerous studies in genetically modified animals emphasizing the molecular clock's significance pathogenesis pathophysiology myocardial ischemia heart failure progression. However, translational preclinical targeting heart's biology are just now emerging leading to a novel field medicine termed medicine. In this review, we explore mechanisms therapies, including (1) intense light, (2) small molecules modulating mechanism, (3) chronotherapies such as drugs meal timings. These promise significant clinical translation for disease. (4) Additionally, address differential functioning mechanism males versus females, consideration biological sex, gender, aging therapies
Language: Английский
Citations
17
The Annual Review of Pharmacology and Toxicology, Journal Year: 2023, Volume and Issue: 64(1), P. 89 - 114
Published: Sept. 19, 2023
Today's challenge for precision medicine involves the integration of impact molecular clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy. Meaningful improvements tolerability and/or medications through proper administration timing have been confirmed over past decade immunotherapy chemotherapy against cancer, as well commonly used pharmacological agents in cardiovascular, metabolic, inflammatory, neurological conditions. Experimental human studies recently revealed sexually dimorphic circadian responses. Dedicated randomized clinical trials should now aim to issue recommendations daily medical practice, integrating innovative technologies remote longitudinal monitoring metrics, statistical prediction clock function from single-timepoint biopsies, multiscale biorhythmic mathematical modelling. Importantly, chronofit patients with a robust function, who would benefit most chronotherapy, need be identified. Conversely, nonchronofit could emerging class chronobiotics targeting clock.
Language: Английский
Citations
33
Circulation Research, Journal Year: 2024, Volume and Issue: 134(6), P. 810 - 832
Published: March 14, 2024
Hypertension is extremely common, affecting approximately 1 in every 2 adults globally. Chronic hypertension the leading modifiable risk factor for cardiovascular disease and premature mortality worldwide. Despite considerable efforts to define mechanisms that underlie hypertension, a potentially major component of disease, role circadian biology has been relatively overlooked both preclinical models humans. Although presence daily patterns observed from level genome whole organism, functional structural impact biological rhythms, including such as misalignment, remains poorly defined. Here, we review rhythms systems regulating blood pressure onset, progression, consequences hypertension. There an emphasis on relation vascular end-organ effects that, individually or combination, contribute complex phenotypes cognitive decline loss cardiac brain health. effective treatment options some individuals, control inadequate substantial portion hypertensive population. Greater insight into may form foundation novel more widely molecular therapies interventions help prevention, treatment, management its related pathophysiology.
Language: Английский
Citations
14
Circulation Research, Journal Year: 2024, Volume and Issue: 134(6), P. 791 - 809
Published: March 14, 2024
Circadian rhythms exert a profound impact on most aspects of mammalian physiology, including the immune and cardiovascular systems. Leukocytes engage in time-of-day–dependent interactions with vasculature, facilitating emigration to surveillance tissues. This review provides an overview circadian control immune-vascular both steady state diseases such as atherosclerosis infarction. vascular facets these interactions, primarily through regulation chemoattractant adhesion molecules endothelial cells. Misaligned light conditions disrupt this rhythm, generally exacerbating In diseases, distinct clock genes, while functioning part integrated system, can have proinflammatory or anti-inflammatory effects interactions. Here, we discuss mechanisms relevance immunopathologies.
Language: Английский
Citations
8
Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 35(7), P. 607 - 623
Published: March 8, 2024
Cardiovascular disease (CVD) is a global health concern. Circadian medicine improves cardiovascular care by aligning treatments with our body's daily rhythms and their underlying cellular circadian mechanisms. Time-based therapies, or chronotherapies, show special promise in clinical cardiology. They optimize treatment schedules for better outcomes fewer side effects recognizing the profound influence of rhythmic body cycles. In this review, we focus on three chronotherapy areas (medication, light, meal timing) potential to enhance care. We also highlight pioneering research new field rest, gut microbiome, novel chronotherapies hypertension, pain management, small molecules that targeting mechanism.
Language: Английский
Citations
7
Circulation Research, Journal Year: 2024, Volume and Issue: 134(6), P. 659 - 674
Published: March 14, 2024
Circadian rhythms in physiology and behavior are ≈24-hour biological cycles regulated by internal clocks (ie, circadian clocks) that optimize organismal homeostasis response to predictable environmental changes. These present virtually all cells the body, including cardiomyocytes. Many decades ago, clinicians researchers became interested studying daily patterns of triggers for sudden cardiac death, incidence arrhythmias. This review highlights historical contemporary studies examining role day/night timing cardiovascular events, delves into changes these events over last few decades, discusses disease-specific differences events. The current understanding environmental, behavioral, mechanisms regulate electrophysiology is examined with a focus on regulation ion channels channel regulatory genes. Understanding contribution arrhythmia susceptibility death will be essential developing future chronotherapies.
Language: Английский
Citations
7
Journal of Human Hypertension, Journal Year: 2024, Volume and Issue: 38(5), P. 420 - 429
Published: Jan. 11, 2024
Chronic kidney disease (CKD) represents a significant global burden. Hypertension is modifiable risk factor for rapid progression of CKD. We extend the stratification by introducing non-parametric determination rhythmic components in 24-h profiles ambulatory blood pressure monitoring (ABPM) Renal Insufficiency Cohort (CRIC) and African American Study Kidney Disease (AASK) cohort using Cox proportional hazards models. find that profiling BP through JTK_CYCLE analysis identifies subgroups CRIC participants were more likely to die due cardiovascular causes. While our fully adjusted model shows trend towards association between absent cyclic death full (HR: 1.71,95% CI: 0.99-2.97, p = 0.056), with history (CVD) their profile had at any time 3.4-times higher than CVD patients present 3.37, 95% 1.45-7.87, 0.005). This increased was not explained dipping or non-dipping pattern ABPM. Due large differences patient characteristics, results do replicate AASK cohort. study suggests as potential novel biomarker unmask excess among CKD prior disease.
Language: Английский
Citations
5
Journal of Biological Rhythms, Journal Year: 2024, Volume and Issue: 39(3), P. 237 - 269
Published: Feb. 20, 2024
Circadian biology's impact on human physical health and its role in disease development progression is widely recognized. The forefront of circadian rhythm research now focuses translational applications to clinical medicine, aiming enhance diagnosis, prognosis, treatment responses. However, the field medicine has predominantly concentrated healthcare, neglecting potential for transformative veterinary thereby overlooking opportunities improve non-human animal welfare. This review consists three main sections. first section into current industry practices agricultural animals, with a particular emphasis horses, broiler chickens, laying hens. second delves small care, primarily focusing our companion namely dogs cats. final explores emerging frontiers encompassing aquaculture, hospital welfare concludes integration One Health principles. In summary, represents highly promising that holds significantly care overall all extending beyond healthcare.
Language: Английский
Citations
5
Current Hypertension Reports, Journal Year: 2023, Volume and Issue: 26(1), P. 31 - 42
Published: Oct. 14, 2023
Language: Английский
Citations
11
Diabetes/Metabolism Research and Reviews, Journal Year: 2024, Volume and Issue: 40(1)
Published: Jan. 1, 2024
Abstract Despite the advancement in blood pressure (BP) lowering medications, uncontrolled hypertension persists, underscoring a stagnation of effective clinical strategies. Novel and lifestyle therapies are needed to prevent manage mitigate future progression cardiovascular chronic kidney diseases. Chrono‐nutrition, aligning timing eating with environmental cues internal biological clocks, has emerged as potential strategy improve BP high‐risk populations. The aim this review is provide an overview circadian physiology emphasis on renal vascular biology. Chrono‐nutrition intervention for discussed current evidence efficacy time‐restricted presented.
Language: Английский
Citations
4