Metal organic framework-based antibacterial agents and their underlying mechanisms

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(16), P. 7138 - 7169

Published: Jan. 1, 2022

MOFs can kill the bacteria efficiently by multiple mechanisms, such as releasing metal ions and/or antibacterial micro-molecules; performing catalytically active site; acting photosensitizers; mimicking enzymes; based on gas therapy and so on.

Language: Английский

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Flexible Accelerated‐Wound‐Healing Antibacterial MXene‐Based Epidermic Sensor for Intelligent Wearable Human‐Machine Interaction

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(47)

Published: Sept. 17, 2022

Abstract Flexible epidermic sensors made from conductive hydrogels are holding bright potential in personalized healthcare, multifunctional electronic skins, and human‐machine interfaces. However, it is still a great challenge to simultaneously realize hydrogel‐based with reliable self‐healing ability remarkable sensing performances high‐performance healthcare (especially electrophysiological signals) for wearable interaction, as well accelerated wound healing subsequent medical treatment together. Herein, flexible healable sensor assembled the facilely prepared antibacterial MXene hydrogel efficiently sensitively interaction. The as‐prepared possesses enhanced mechanical performance, outstanding capability, injectability, facile degradability, excellent biocompatibility, robust ability, which capable of being into monitor human movements rehabilitation training, detect tiny signals diagnosis cardiovascular‐ muscle‐related diseases, be employed In addition, can utilized treat infection effectively accelerate healing. Thus, sheds light on preparing integration personal health smart interaction next‐generation artificial skins.

Language: Английский

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Multifunctional TiO2/C nanosheets derived from 3D metal–organic frameworks for mild-temperature-photothermal-sonodynamic-chemodynamic therapy under photoacoustic image guidance

Journal of Colloid and Interface Science, Journal Year: 2022, Volume and Issue: 621, P. 360 - 373

Published: April 14, 2022

Language: Английский

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Emerging porous organic polymers for biomedical applications

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(4), P. 1377 - 1414

Published: Jan. 1, 2022

This review summarizes and discusses the recent progress in porous organic polymers for diverse biomedical applications such as drug delivery, biomacromolecule immobilization, phototherapy, biosensing, bioimaging, antibacterial applications.

Language: Английский

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Current status and prospects of metal–organic frameworks for bone therapy and bone repair

Journal of Materials Chemistry B, Journal Year: 2022, Volume and Issue: 10(27), P. 5105 - 5128

Published: Jan. 1, 2022

In the present perspective, use of MOFs in bone therapy and repair has been summarized, an outlook on future direction provided.

Language: Английский

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Photothermal Nanozyme‐Based Microneedle Patch against Refractory Bacterial Biofilm Infection via Iron‐Actuated Janus Ion Therapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(51)

Published: Oct. 14, 2022

Owing to high antibiotic resistance and thermotolerance, bacterial biofilm infections (BBIs) are refractory elimination. Iron is essential for growth metabolism, bacteria can thus accumulate iron from surrounding cells maintain formation survival. Consequently, deficiency in the microenvironment (BME) leads functional failure of innate immune cells. Herein, a novel antibiofilm strategy iron-actuated Janus ion therapy (IJIT) proposed regulate metabolism both A BME-responsive photothermal microneedle patch (FGO@MN) synthesized by Fe3 O4 nanoparticles on graphene oxide nanosheets then encapsulated methacrylated hyaluronic acid needle tips. The catalytic product ·OH FGO@MN BME disrupts heat-shock proteins, coercing thermal sensitization. As synergistic mild treatment triggers uptake, intracellular overload further induces ferroptosis-like death. Moreover, iron-nourished neutrophils around be rejuvenated reactivating suppressed function. Thus, more than 95% BBIs elimination achieved combining heat stress-triggered interference with iron-nutrient reactivation. Furthermore, vivo experiments validate scavenging BBI after 15 days, suggesting promising perspective IJIT future clinical application.

Language: Английский

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Photocatalytic Antimicrobials: Principles, Design Strategies, and Applications

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(22), P. 12371 - 12430

Published: Aug. 24, 2023

Nowadays, the increasing emergence of antibiotic-resistant pathogenic microorganisms requires search for alternative methods that do not cause drug resistance. Phototherapy strategies (PTs) based on photoresponsive materials have become a new trend in inactivation due to their spatiotemporal controllability and negligible side effects. Among those phototherapy strategies, photocatalytic antimicrobial therapy (PCAT) has emerged as an effective promising strategy recent years. In process treatment, are excited by different wavelengths lights produce reactive oxygen species (ROS) or other toxic killing various microbes, such bacteria, viruses, fungi, parasites, algae. Therefore, this review timely summarizes latest progress PCAT field, with emphasis development antimicrobials (PCAMs), underlying mechanisms, design multiple practical applications local infections therapy, personal protective equipment, water purification, coatings, wound dressings, food safety, antibacterial textiles, air purification. Meanwhile, we also present challenges perspectives widespread implementation therapeutics. We hope result review, will flourish weapon against antibiotic

Language: Английский

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Preparation of Photocatalytic and Antibacterial MOF Nanozyme Used for Infected Diabetic Wound Healing

ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 14(16), P. 18194 - 18208

Published: April 12, 2022

Bacterial infection has been a considerable obstacle for diabetic wound healing. A multifunctional nanoplatform used as nanozyme bacterial infected is extremely attractive. Therefore, gold nanoclusters modified zirconium-based porphyrin metal-organic frameworks (Au NCs@PCN) were constructed by an in situ growth method. Through SEM, TEM, and EDS mapping, the surface of ellipsoid-shaped particles around 190 nm was observed to be evenly interspersed with 5-8 nanoclusters. Notably, Au NCs@PCN exhibits excellent performance exciting ROS generation photothermal effects. Under near-infrared (NIR) laser irradiation, can heated 56.2 °C produce ROS, showing effective killing effect on bacteria. Antibacterial studies showed that inhibited MRSA AmprE. coli destroying membrane structure inducing protein leakage up 95.3% 90.6%, respectively. Animal experiments treated rats had reduced coverage 2.7% within 21 days. The immunoblot analysis proangiogenic proepithelial cell proliferation factors expressed significantly up-regulated. These results prove photocatalytic activity broad application prospect promoting

Language: Английский

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Porphyrin-Based Two-Dimensional Layered Metal–Organic Framework with Sono-/Photocatalytic Activity for Water Decontamination

ACS Nano, Journal Year: 2021, Volume and Issue: 16(1), P. 1346 - 1357

Published: Dec. 27, 2021

Water treatment is crucial to improve the water quality and reduce diarrheal chronological diseases caused by excessive discharge of organic dyes other waste. The development expansion efficient catalysts for degradation sterilization has attracted widespread attention. Herein, we report an example a porphyrin-based two-dimensional layered metal-organic framework (MOF) (2DZnTcpp) its sono-/photocatalytic bactericidal activity. dislocated layers effectively avoid close π-π stacking provide porous space oxygen/water/dye contact. introduction Zn ions increases spin orbital coupling through heavy atom effect promotes intersystem crossing process singlet oxygen generation. effective ligand-to-metal charge transfer open catalytic sites also facilitate splitting hydroxyl radical These features together promote reactive species (ROS) generation 2DZnTcpp under light illumination or ultrasound sonication. It worth noting that with high specific surface area porosity shows dye Moreover, could largely inactivate Escherichia coli irradiation (the power 1 sun) sonication 30 min efficiencies over 99.99999%. This work provides approach design synthesis MOF-based sono-/photocatalysts used in purification textile wastewater committed establishment more efficient, fast, environmentally friendly system.

Language: Английский

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Smartphone-based platforms implementing microfluidic detection with image-based artificial intelligence

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: March 11, 2023

Abstract The frequent outbreak of global infectious diseases has prompted the development rapid and effective diagnostic tools for early screening potential patients in point-of-care testing scenarios. With advances mobile computing power microfluidic technology, smartphone-based health platform drawn significant attention from researchers developing devices that integrate optical detection with artificial intelligence analysis. In this article, we summarize recent progress these platforms, including aspects chips, imaging modalities, supporting components, software algorithms. We document application platforms terms objects, molecules, viruses, cells, parasites. Finally, discuss prospects future platforms.

Language: Английский

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