The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth

Cancer Cell, Journal Year: 2023, Volume and Issue: 41(3), P. 374 - 403

Published: March 1, 2023

Language: Английский

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Biology and therapeutic targeting of vascular endothelial growth factor A

Nature Reviews Molecular Cell Biology, Journal Year: 2023, Volume and Issue: 24(11), P. 816 - 834

Published: July 25, 2023

Language: Английский

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Mucosal immune responses to infection and vaccination in the respiratory tract

Immunity, Journal Year: 2022, Volume and Issue: 55(5), P. 749 - 780

Published: May 1, 2022

Language: Английский

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Understanding tumour endothelial cell heterogeneity and function from single-cell omics

Nature reviews. Cancer, Journal Year: 2023, Volume and Issue: 23(8), P. 544 - 564

Published: June 22, 2023

Language: Английский

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Controlling the biodistribution and clearance of nanomedicines

Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 2(3), P. 214 - 232

Published: Dec. 20, 2023

Language: Английский

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Single cell atlas identifies lipid-processing and immunomodulatory endothelial cells in healthy and malignant breast

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Sept. 20, 2022

Abstract Since a detailed inventory of endothelial cell (EC) heterogeneity in breast cancer (BC) is lacking, here we perform single RNA-sequencing 26,515 cells (including 8433 ECs) from 9 BC patients and compare them to published EC taxonomies lung tumors. Angiogenic ECs are phenotypically similar, while other subtypes different. Predictive interactome analysis reveals known but also previously unreported receptor-ligand interactions between immune cells, suggesting an involvement responses. We identify capillary subtype (LIPEC (Lipid Processing EC)), which expresses genes involved lipid processing that regulated by PPAR-γ more abundant peri-tumoral tissue. Retrospective 4648 treatment with metformin (an indirect signaling activator) provides long-lasting clinical benefit positively associated LIPEC abundance. Our findings warrant further exploration this LIPEC/PPAR-γ link for treatment.

Language: Английский

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Cellular and Molecular Players in the Tumor Microenvironment of Renal Cell Carcinoma

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(12), P. 3888 - 3888

Published: June 7, 2023

Globally, clear-cell renal cell carcinoma (ccRCC) represents the most prevalent type of kidney cancer. Surgery plays a key role in treatment this cancer, although one third patients are diagnosed with metastatic ccRCC and about 25% will develop recurrence after nephrectomy curative intent. Molecular-target-based agents, such as tyrosine kinase inhibitors (TKIs) immune checkpoint (ICIs), recommended for advanced cancers. In addition to cancer cells, tumor microenvironment (TME) includes non-malignant types embedded an altered extracellular matrix (ECM). The evidence confirms that interactions among cells TME elements exist thought play crucial roles development making them promising therapeutic targets. TME, unfavorable pH, waste product accumulation, competition nutrients between may be regarded further possible mechanisms escape. To enhance immunotherapies reduce resistance, it is first understand how work interact other cancer-associated complex microenvironment.

Language: Английский

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Immunomodulatory biomaterials against bacterial infections: Progress, challenges, and future perspectives

The Innovation, Journal Year: 2023, Volume and Issue: 4(6), P. 100503 - 100503

Published: Aug. 29, 2023

•Insights into the intricate facets of immune microenvironment hold key to pioneering clinical strategies in combatting bacterial infections.•The design principles for antimicrobial biomaterials vary depending on at different stages infection.•Immunomodulatory display robust efficacy and vaccine attributes animals trials, promising intractable infections. Bacterial infectious diseases are one leading causes death worldwide. Even with use multiple antibiotic treatment strategies, 4.95 million people died from drug-resistant infections 2019. By 2050, number deaths will reach 10 annually. The increasing mortality may be partly due heterogeneity infection microenvironment, such as bacteria, biofilms, persister cells, intracellular small colony variants. In addition, complexity makes direct activity unsatisfactory long-term chronic attributed failing modulate active action cells. Therefore, there is an urgent need effective alternatives treat Accordingly, development immunomodulatory has recently received considerable interest; however, a comprehensive review their research progress lacking. this review, we focus mainly future perspectives used infection. First, describe characteristics acute phases Then, highlight corresponding advantages disadvantages. Moreover, discuss biomaterial-mediated vaccines' potential applications challenges activating innate adaptive memory. This serve reference studies develop next-generation accelerate translation practice.

Language: Английский

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Bacterial lipopolysaccharide-induced endothelial activation and dysfunction: a new predictive and therapeutic paradigm for sepsis

European journal of medical research, Journal Year: 2023, Volume and Issue: 28(1)

Published: Sept. 12, 2023

Abstract Background Lipopolysaccharide, a highly potent endotoxin responsible for severe sepsis, is the major constituent of outer membrane gram-negative bacteria. Endothelial cells participate in both innate and adaptive immune responses as first cell types to detect lipopolysaccharide or other foreign debris bloodstream. are able recognize presence LPS recruit specific adaptor proteins domains TLR4, thereby initiating an intracellular signaling cascade. However, binding endothelial induces activation even damage, manifested by expression proinflammatory cytokines adhesion molecules that lead sepsis. Main findings involved local systemic inflammation, activating immunity. Translocation into circulation causes endotoxemia. dysfunction, including exaggerated coagulopathy vascular leakage, may play central role dysregulated host response pathogenesis By discussing many strategies used treat this review attempts provide overview how ever more complex syndrome sepsis potential development novel therapeutics. Conclusions To reduce patient morbidity mortality, preservation function would be management Graphical

Language: Английский

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The evolving functions of the vasculature in regulating adipose tissue biology in health and obesity

Nature Reviews Endocrinology, Journal Year: 2023, Volume and Issue: 19(12), P. 691 - 707

Published: Sept. 25, 2023

Language: Английский

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