From Antibacterial to Antibiofilm Targeting: An Emerging Paradigm Shift in the Development of Quaternary Ammonium Compounds (QACs)

ACS Infectious Diseases, Journal Year: 2023, Volume and Issue: 9(3), P. 394 - 422

Published: Feb. 15, 2023

In a previous development stage, mostly individual antibacterial activity was target in the optimization of biologically active compounds and antiseptic agents. Although this targeting is still valuable, new trend has appeared since discovery superhigh resistance bacterial cells upon their aggregation into groups. Indeed, it now well established that great majority pathogenic germs are found environment as surface-associated microbial communities called biofilms. The protective properties biofilms resistance, even to high concentrations biocides, cause many chronic infections medical settings lead serious economic losses various areas. A paradigm shift from also affecting more complex cellular frameworks taking place involves multiple strategies for combating with effective at different stages microbiome formation. Quaternary ammonium (QACs) play key role these treatments prophylactic techniques on basis both use agents combination technologies. review, we summarize literature data effectiveness using commercially available newly synthesized QACs, synergistic treatment based them. As an important focus, developing applying antimicrobial coatings prevent formation surfaces over time discussed. information analyzed review will be useful researchers engineers working fields, including generation applied materials; understanding biofilm surface growth; conducting research medical, pharmaceutical, materials sciences. regular studies widely conducted, promising evaluate antibiofilm comprehensive study order meet current requirements highly needed practical applications.

Language: Английский

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Single‐Atom Nanozymes for Catalytic Therapy: Recent Advances and Challenges

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(16)

Published: Jan. 4, 2024

Abstract As a powerful tool, nanozyme catalysts broaden the avenues to implement bio‐inspired solutions for addressing many important concerns, covering energy, healthcare, environment, and more. Recent endeavors, characterized by atomic precision, have enabled extensive exploration of single‐atom nanozymes (SAzymes) with high catalytic activity, superior substrate selectivity, integrated multifunctionalities, thus becoming an emerging field that bridges nanotechnology biology. This review provides brief outline progress summarizes latest research advances regarding SAzymes in biomedical therapeutics, mainly including tumor therapy, wound antibacterial tissue anti‐inflammatory focus on their prototypical synthesis therapeutic mechanisms. Finally, current challenges future perspectives engineering advanced are also discussed outlooked. It is anticipated this area shall provide useful guidance therapy.

Language: Английский

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Janus liposozyme for the modulation of redox and immune homeostasis in infected diabetic wounds

Nature Nanotechnology, Journal Year: 2024, Volume and Issue: 19(8), P. 1178 - 1189

Published: May 13, 2024

Language: Английский

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Specific Chemiluminescence Imaging and Enhanced Photodynamic Therapy of Bacterial Infections by Hemin‐Modified Carbon Dots

Small, Journal Year: 2023, Volume and Issue: 19(31)

Published: March 25, 2023

Abstract Antibacterial photodynamic therapy (aPDT) is a promising antibiotics‐alternative strategy for bacterial infectious diseases, which features broad‐spectrum antibacterial activity with low risk of inducing resistance. However, clinical applications aPDT are still hindered by the hydrophobicity‐caused inadequate conventional photosensitizers and hypoxic microenvironment infections. To address these problems, herein, developed to achieve specific chemiluminescence (CL) imaging enhanced PDT infections using hemin‐modified carbon dots (H‐CDs). The H‐CDs can be facilely prepared exhibit favorable water solubility, augmented activity, unique peroxidase‐mimicking capacity. Compared free CDs, efficacy significantly due increased electron–hole separation efficiency. Moreover, peroxidase catalytic performance enables not only infection identification via microenvironment‐responsive CL but also oxygen self‐supplied hypoxia‐relief‐enhanced bacteria inactivation effects. Finally, efficiencies validated in both vivo abscess infected wound models. This work may provide an effective platform selective imaging‐guided treatment

Language: Английский

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Hydrogel-based dressings designed to facilitate wound healing

Materials Advances, Journal Year: 2023, Volume and Issue: 5(4), P. 1364 - 1394

Published: Dec. 20, 2023

This review provides an overview of the functionalities hydrogel-based dressings and their role in promoting wound healing.

Language: Английский

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