Gut microbiota in colorectal cancer development and therapy

Nature Reviews Clinical Oncology, Journal Year: 2023, Volume and Issue: 20(7), P. 429 - 452

Published: May 11, 2023

Language: Английский

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Gut microbiota and its metabolites in depression: from pathogenesis to treatment

EBioMedicine, Journal Year: 2023, Volume and Issue: 90, P. 104527 - 104527

Published: March 22, 2023

Language: Английский

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Microenvironment‐Activated Nanozyme‐Armed Bacteriophages Efficiently Combat Bacterial Infection

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(30)

Published: April 21, 2023

Bacterial infection is one of the greatest challenges to public health, requiring new therapeutic methods. Herein, an innovative nanozyme-armed phage (phage@palladium (Pd)) system fabricated for combating bacterial infection. The proposed phage@Pd preserves function phages achieve precise recognition and adhesion host Escherichia coli. In aid phages, ultrasmall Pd nanozymes equipped with conspicuous pH-dependent peroxidase-like activity can generate toxic hydroxyl radical around bacteria in acidic hydrogen-peroxide-overexpressed microenvironment while remaining inert physiological conditions, thus realizing noteworthy elimination at infected sites, meantime ensuring biological safety healthy tissues. addition, filamentous structure also enhance its bactericidal efficiency toward nonhost by randomly entangling on them, indicating possible broad-spectrum germicidal efficacy. Notably, not only eradicate planktonic bacteria, but kill inside biofilm vitro. For both vivo models acute pneumonia or subcutaneous abscess, shows significant eliminating promoting tissue recovery. These results demonstrate that nanohybrid a safe effective antimicrobial agent, providing insight into development advanced antibacterial materials.

Language: Английский

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The honeybee microbiota and its impact on health and disease

Nature Reviews Microbiology, Journal Year: 2023, Volume and Issue: 22(3), P. 122 - 137

Published: Dec. 4, 2023

Language: Английский

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The gut virome is associated with stress-induced changes in behaviour and immune responses in mice

Nature Microbiology, Journal Year: 2024, Volume and Issue: 9(2), P. 359 - 376

Published: Feb. 5, 2024

The microbiota-gut-brain axis has been shown to play an important role in the stress response, but previous work focused primarily on of bacteriome. gut virome constitutes a major portion microbiome, with bacteriophages having potential remodel bacteriome structure and activity. Here we use mouse model chronic social stress, employ 16S rRNA whole metagenomic sequencing faecal pellets determine how is modulated by contributes effects stress. We found that led behavioural, immune alterations mice were associated changes bacteriophage class Caudoviricetes unassigned viral taxa. To whether these causally related stress-associated behavioural or physiological outcomes, conducted transplant from before autochthonously transferred it undergoing transfer protected against behaviour sequelae restored stress-induced select circulating cell populations, cytokine release, gene expression amygdala. These data provide evidence plays modulation during indicating populations should be considered when designing future microbiome-directed therapies.

Language: Английский

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A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Sept. 23, 2024

Language: Английский

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Carbon starvation raises capacities in bacterial antibiotic resistance and viral auxiliary carbon metabolism in soils

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(16)

Published: April 10, 2024

Organic carbon availability in soil is crucial for shaping microbial communities, yet, uncertainties persist concerning adaptations to levels and the ensuing ecological evolutionary consequences. We investigated organic metabolism, antibiotic resistance, virus–host interactions soils subjected 40 y of chemical fertilization that led contrasting availability: carbon-poor carbon-rich soils, respectively. Carbon-poor drove enrichment putative genes involved matter decomposition exhibited specialization utilizing complex compounds, reflecting scramble competition. This confers a competitive advantage communities but reduces their buffering capacity terms metabolisms, making them more vulnerable environmental fluctuations. Additionally, viral auxiliary metabolic linked metabolism increased host competitiveness adaptability through strategy akin “piggyback winner.” Furthermore, resistance genes, particularly low-abundance drug categories, were enriched as an consequence warfare (i.e., interference competition). raises concerns about potential dissemination from conventional agriculture relies on chemical-only fertilization. Consequently, starvation resulting long-term increases competition, underscoring importance implementing sustainable agricultural practices mitigate emergence spread antimicrobial increase storage.

Language: Английский

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Diet, microbiota, and the mucus layer: The guardians of our health

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 13, 2022

The intestinal tract is an ecosystem in which the resident microbiota lives symbiosis with its host. This symbiotic relationship key to maintaining overall health, dietary habits of host representing one main external factors shaping microbiome-host relationship. Diets high fiber and low fat sugars, as opposed Western high-fat diets, have been shown a beneficial effect on health by promoting growth bacteria, improve mucus barrier function immune tolerance, while inhibiting pro-inflammatory responses their downstream effects. On contrary, diets sugars associated alterations composition/functionality subsequent development chronic diseases such food allergies, inflammatory bowel disease, metabolic disease. In this review, we provided updated overview current understanding connection between diet, microbiota, special focus role homeostasis modulating gut microbiota.

Language: Английский

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Benzo[a]pyrene stress impacts adaptive strategies and ecological functions of earthworm intestinal viromes

The ISME Journal, Journal Year: 2023, Volume and Issue: 17(7), P. 1004 - 1014

Published: April 17, 2023

The earthworm gut virome influences the structure and function of microbiome, which in turn worm health ecological functions. However, despite its soil quality implications, it remains elusive how intestinal phages respond to different environmental stress, such as pollution. Here we used metagenomics metatranscriptomics investigate interactions between their bacteria under benzo[a]pyrene (BaP) concentrations. Low-level BaP (0.1 mg kg-1) stress stimulated microbial metabolism (1.74-fold control), enhanced antiphage defense system (n = 75) against infection (8 phage-host pairs). exposure resulted highest proportion lysogenic (88%), prophages expressed auxiliary metabolic genes (AMGs) associated with nutrient transformation (e.g., amino acid metabolism). In contrast, high-level (200 disrupted suppressed systems 29), leading increase phage-bacterium association (37 pairs) conversion lytic (lysogenic ratio declined 43%). Despite fluctuating interactions, phage-encoded AMGs related antioxidant pollutant degradation were enriched, apparently alleviate pollution stress. Overall, these findings expand our knowledge complex pollution-stressed guts, deepen understanding evolutionary roles phages.

Language: Английский

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Social anxiety disorder-associated gut microbiota increases social fear

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 121(1)

Published: Dec. 26, 2023

Social anxiety disorder (SAD) is a crippling psychiatric characterized by intense fear or in social situations and their avoidance. However, the underlying biology of SAD unclear better treatments are needed. Recently, gut microbiota has emerged as key regulator both brain behaviour, especially those related to function. Moreover, increasing data supports role for immune function oxytocin signalling responses. To investigate whether plays causal modulating behaviours relevant SAD, we transplanted from patients, which was identified 16S rRNA sequencing be differential composition compared healthy controls, mice. Although mice that received had normal across battery tests designed assess depression general anxiety-like behaviours, they specific heightened sensitivity fear, model SAD. This distinct response coupled with changes central peripheral expression bed nucleus stria terminalis. work demonstrates an interkingdom basis responses posits microbiome potential therapeutic target

Language: Английский

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