Foodborne
bacterial
diarrhea
involves
complex
pathogen-microbiota-host
interactions.
Pathogen-displacing
probiotics
are
increasingly
popular,
but
heterogeneous
patient
outcomes
highlighted
the
need
to
understand
individualized
host-probiotic
activity.
Using
mouse
gut
commensal
Escherichia
coli
8178
and
human
probiotic
E.
Nissle
1917,
we
found
that
degree
of
protection
against
enteric
pathogen
Salmonella
enterica
serovar
Typhimurium
(S.
Tm)
varies
across
mice
with
distinct
microbiotas.
Pathogen
clearance
is
linked
enteropathy
severity
subsequent
recruitment
intraluminal
neutrophils,
which
differs
in
a
microbiota-dependent
manner.
By
combining
knockout
antibody-mediated
depletion
models
genetics,
show
neutrophils
host-derived
reactive
oxygen
species
directly
influence
coli-mediated
S.
Tm
displacement
by
potentiating
siderophore-bound
toxin
killing.
Our
work
demonstrates
how
host
immune
factors
shape
pathogen-displacing
efficiency
while
also
revealing
an
unconventional
antagonistic
interaction
where
synergize
displace
pathogen.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Feb. 16, 2024
Abstract
The
human
gastrointestinal
tract
is
populated
with
a
diverse
microbial
community.
vast
genetic
and
metabolic
potential
of
the
gut
microbiome
underpins
its
ubiquity
in
nearly
every
aspect
biology,
including
health
maintenance,
development,
aging,
disease.
advent
new
sequencing
technologies
culture-independent
methods
has
allowed
researchers
to
move
beyond
correlative
studies
toward
mechanistic
explorations
shed
light
on
microbiome–host
interactions.
Evidence
unveiled
bidirectional
communication
between
central
nervous
system,
referred
as
“microbiota–gut–brain
axis”.
microbiota–gut–brain
axis
represents
an
important
regulator
glial
functions,
making
it
actionable
target
ameliorate
development
progression
neurodegenerative
diseases.
In
this
review,
we
discuss
mechanisms
As
provides
essential
cues
microglia,
astrocytes,
oligodendrocytes,
examine
communications
microbiota
these
cells
during
healthy
states
Subsequently,
diseases
using
metabolite-centric
approach,
while
also
examining
role
microbiota-related
neurotransmitters
hormones.
Next,
targeting
intestinal
barrier,
blood–brain
meninges,
peripheral
immune
system
counteract
dysfunction
neurodegeneration.
Finally,
conclude
by
assessing
pre-clinical
clinical
evidence
probiotics,
prebiotics,
fecal
transplantation
A
thorough
comprehension
will
foster
effective
therapeutic
interventions
for
management
FEMS Microbiology Reviews,
Journal Year:
2023,
Volume and Issue:
47(4)
Published: July 1, 2023
Abstract
In
humans,
many
diseases
are
associated
with
alterations
in
gut
microbiota,
namely
increases
or
decreases
the
abundance
of
specific
bacterial
groups.
One
example
is
genus
Faecalibacterium.
Numerous
studies
have
underscored
that
low
levels
Faecalibacterium
correlated
inflammatory
conditions,
bowel
disease
(IBD)
forefront.
Its
representation
also
diminished
case
several
diseases,
including
colorectal
cancer
(CRC),
dermatitis,
and
depression.
Additionally,
relative
presence
this
considered
to
reflect,
at
least
part,
intestinal
health
status
because
frequently
present
reduced
individuals
gastrointestinal
disorders.
review,
we
first
thoroughly
describe
updates
taxonomy
Faecalibacterium,
which
has
transformed
a
single-species
taxon
multispecies
over
last
decade.
We
then
explore
links
discovered
between
various
since
IBD-focused
were
published.
Next,
examine
current
available
strategies
for
modulating
gut.
Finally,
summarize
mechanisms
underlying
beneficial
effects
been
attributed
genus.
Together,
epidemiological
experimental
data
strongly
support
use
as
next-generation
probiotic
(NGP)
live
biotherapeutic
product
(LBP).
Science,
Journal Year:
2023,
Volume and Issue:
382(6676)
Published: Dec. 14, 2023
The
human
gut
microbiome
plays
an
important
role
in
resisting
colonization
of
the
host
by
pathogens,
but
we
lack
ability
to
predict
which
communities
will
be
protective.
We
studied
how
bacteria
influence
two
major
bacterial
both
vitro
and
gnotobiotic
mice.
Whereas
single
species
alone
had
negligible
effects,
resistance
greatly
increased
with
community
diversity.
Moreover,
this
community-level
rested
critically
upon
certain
being
present.
explained
these
ecological
patterns
through
collective
resistant
consume
nutrients
that
overlap
those
used
pathogen.
Furthermore,
applied
our
findings
successfully
resist
a
novel
target
strain.
Our
work
provides
reason
why
diversity
is
beneficial
suggests
route
for
rational
design
pathogen-resistant
communities.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Oct. 9, 2023
Abstract
Individual
variability
in
drug
response
(IVDR)
can
be
a
major
cause
of
adverse
reactions
(ADRs)
and
prolonged
therapy,
resulting
substantial
health
economic
burden.
Despite
extensive
research
pharmacogenomics
regarding
the
impact
individual
genetic
background
on
pharmacokinetics
(PK)
pharmacodynamics
(PD),
diversity
explains
only
limited
proportion
IVDR.
The
role
gut
microbiota,
also
known
as
second
genome,
its
metabolites
modulating
therapeutic
outcomes
human
diseases
have
been
highlighted
by
recent
studies.
Consequently,
burgeoning
field
pharmacomicrobiomics
aims
to
explore
correlation
between
microbiota
variation
IVDR
or
ADRs.
This
review
presents
an
up-to-date
overview
intricate
interactions
classical
agents
for
systemic
diseases,
including
cancer,
cardiovascular
(CVDs),
endocrine
others.
We
summarise
how
directly
indirectly,
modify
absorption,
distribution,
metabolism,
excretion
(ADME)
drugs.
Conversely,
drugs
modulate
composition
function
leading
changes
microbial
metabolism
immune
response.
discuss
practical
challenges,
strategies,
opportunities
this
field,
emphasizing
critical
need
develop
innovative
approach
multi-omics,
integrate
various
data
types,
genomic
data,
well
translate
lab
into
clinical
practice.
To
sum
up,
represents
promising
avenue
address
improve
patient
outcomes,
further
is
imperative
unlock
full
potential
precision
medicine.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(4), P. 967 - 967
Published: April 20, 2023
Inflammatory
bowel
disease
(IBD)
is
a
long-term,
progressive,
and
recurrent
intestinal
inflammatory
disorder.
The
pathogenic
mechanisms
of
IBD
are
multifaceted
associated
with
oxidative
stress,
unbalanced
gut
microbiota,
aberrant
immune
response.
Indeed,
stress
can
affect
the
progression
development
by
regulating
homeostasis
microbiota
Therefore,
redox-targeted
therapy
promising
treatment
option
for
IBD.
Recent
evidence
has
verified
that
Chinese
herbal
medicine
(CHM)-derived
polyphenols,
natural
antioxidants,
able
to
maintain
redox
equilibrium
in
tract
prevent
abnormal
radical
responses.
Here,
we
provide
comprehensive
perspective
implementing
antioxidants
as
potential
candidate
medications.
In
addition,
demonstrate
novel
technologies
stratagems
promoting
antioxidative
properties
CHM-derived
including
delivery
systems,
chemical
modifications,
combination
strategies.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Jan. 11, 2024
Despite
the
plant
health-promoting
effects
of
microbiota,
these
assemblages
also
comprise
potentially
detrimental
microbes.
How
immunity
controls
its
microbiota
to
promote
health
under
conditions
remains
largely
unknown.
We
find
that
commensal
bacteria
isolated
from
healthy
Arabidopsis
plants
trigger
diverse
patterns
reactive
oxygen
species
(ROS)
production
dependent
on
immune
receptors
and
completely
NADPH
oxidase
RBOHD
selectively
inhibited
specific
commensals,
notably
Xanthomonas
L148.
Through
random
mutagenesis,
we
L148
gspE,
encoding
a
type
II
secretion
system
(T2SS)
component,
is
required
for
damaging
rbohD
mutant
plants.
In
planta
bacterial
transcriptomics
reveals
suppresses
most
T2SS
gene
expression
including
gspE.
colonization
protected
against
pathogen,
when
gspE
was
by
ROS
or
mutation.
Thus,
negative
feedback
loop
between
tames
leaf
turns
it
into
microbe
beneficial
host.
Immunity,
Journal Year:
2024,
Volume and Issue:
57(4), P. 613 - 631
Published: April 1, 2024
SummaryWhile
largely
neglected
over
decades
during
which
adaptive
immunity
captured
most
of
the
attention,
innate
immune
mechanisms
have
now
become
central
to
our
understanding
immunology.
Innate
provides
first
barrier
infection
in
vertebrates,
and
it
is
sole
mechanism
host
defense
invertebrates
plants.
also
plays
a
critical
role
maintaining
homeostasis,
shaping
microbiota,
disease
contexts
such
as
cancer,
neurodegeneration,
metabolic
syndromes,
aging.
The
emergence
field
has
led
an
expanded
view
system,
no
longer
restricted
vertebrates
instead
concerns
all
metazoans,
plants,
even
prokaryotes.
study
given
rise
new
concepts
language.
Here,
we
review
history
definition
core
immunity,
discussing
their
value
fruitfulness
long
run.