JADA Foundational Science, Journal Year: 2025, Volume and Issue: 4, P. 100043 - 100043
Published: Jan. 1, 2025
We are pleased to introduce a new series, "Innovations of Excellence, powered by ADA Forsyth," which provides forum for brief introductions technologies, therapeutic approaches, and health care trends interest oral clinicians researchers-a "window" into the latest scientific discoveries.Inspired
Language: Английский
Dentistry Journal, Journal Year: 2025, Volume and Issue: 13(3), P. 100 - 100
Published: Feb. 26, 2025
Periodontitis and diabetes mellitus are two highly prevalent chronic conditions that share a bidirectional relationship, significantly impacting public health. Periodontitis, gum inflammation caused by microbial dysbiosis, aggravates glycemic control in diabetics, while uncontrolled heightens periodontitis severity. These create vicious cycle, where dysbiosis mutually drive disease progression, exacerbating systemic The underlying mechanisms involve inflammation, immune dysfunction, with both diseases contributing to chain of exacerbates This relationship is significant because managing one condition can impact the other. In diabetic individuals, interventions such as periodontal therapy have shown effectiveness improving control, underscoring potential integrated strategies for these simultaneously. this review, we highlight importance deeper understanding molecular immunological interactions between essential developing therapeutic approaches, enhance quality life patient significantly.
Language: Английский
Citations
1
ACS Central Science, Journal Year: 2025, Volume and Issue: unknown
Published: March 26, 2025
Mutanofactins are a family of natural products produced by Streptococcus mutans from the human oral microbiome. We report unified approach to all mutanofactins developing total synthesis amenable diversification. The key success for most complex members, 607 and 697, was an acyl ketene based strategy. Access enabled comprehensive biological profiling, where we demonstrate that biofilm promoting in mutans. Experiments were extended other inhabitants microbiome first time: gordonii oralis, two early colonizers, similarly affected with being promoting. Conversely, Veillonella dispar Fusobacterium nucleatum showed little no reaction mutanofactins. Biophysical investigations on quartz crystal microbalance dissipation monitoring atomic force microscopy reveal previously unknown mucin–mutanofactin 697 interaction. Incubation mucin layer mutanofactin induces morphology change within layer, which promotes bacterial adhesion formation. This unique property might be stages formation Combined, interdisciplinary consisting synthesis, microbiology biophysical characterization provides insight into roles
Language: Английский
Citations
1
Small, Journal Year: 2023, Volume and Issue: 20(19)
Published: Dec. 5, 2023
Abstract Topical antibiotics can be utilized to treat periodontitis, while their delivery stratagems with controlled release and long‐lasting bactericidal inhibition are yet challenging. Herein, inspired by the defensive behavior of cuttlefish expelling ink, this work develops innovative thermal‐responsive melanin‐integrated porous microparticles (MPs) through microfluidic synthesis for periodontitis treatment. These MPs composed melanin nanoparticles (NPs), poly(N‐isopropylacrylamide) (PNIPAM), agarose. Benefiting from excellent biocompatibility large surface area ratio MPs, they deliver abundant NPs. Under near‐infrared irradiation, NPs convert photo energy into thermal energy. This leads agarose melting subsequent shrinkage microspheres induced pNIPAM, thereby facilitating In addition, released serve as a highly effective photothermal agent, displaying potent antibacterial activity against porphyromonas gingivalis possessing natural anti‐inflammatory properties. unique characteristics further demonstrated in vivo experiments, showing effects treatment infected wounds periodontitis. Therefore, catfish‐inspired photo‐responsive controlled‐release drug hold tremendous potential clinical applications.
Language: Английский
Citations
19
Medicine Plus, Journal Year: 2024, Volume and Issue: 1(1), P. 100003 - 100003
Published: Jan. 12, 2024
Homeostasis is essential for the maintenance of health, and how it maintained focus attention in homeostatic medicine. As a natural dietary nutrient, nitrate critical regulating homeostasis. This article summarizes nitrate's cognitive history, sources, metabolism. It discusses relationship possible mechanism between organism homeostasis from three aspects: flora homeostasis, inflammation-immunity energy metabolism as well clinical application scenarios promising new generation drugs, including preventing treating multi-system diseases, reducing injury, improving exercise ability, glucose lipid metabolism, assisting tumor treatment. An increased understanding impact on body could foster research concept its disease prevention
Language: Английский
Citations
8
Journal of Oral Microbiology, Journal Year: 2024, Volume and Issue: 16(1)
Published: May 1, 2024
To explore the manifestations of bacteriophages in different oral disease ecologies, including periodontal diseases, dental caries, endodontic infections, and cancer, as well to propel phage therapy for safer more effective clinical application field dentistry.
Language: Английский
Citations
8
Microbiology and Molecular Biology Reviews, Journal Year: 2024, Volume and Issue: 88(2)
Published: March 20, 2024
SUMMARYThe genus
Language: Английский
Citations
7
Bioactive Materials, Journal Year: 2024, Volume and Issue: 41, P. 271 - 292
Published: July 24, 2024
Periodontitis is an inflammatory disease caused by bacterial biofilms, which leads to the destruction of periodontal tissue. Current treatments, such as mechanical cleaning and antibiotics, struggle effectively address persistent inflammation, tissue damage. A new approach involves developing a Janus nanomotor (J-CeM@Au) coating cerium dioxide-doped mesoporous silica (CeM) with gold nanoparticles (AuNPs). This exhibits thermophoretic motion when exposed near-infrared (NIR) laser light due temperature gradient produced photothermal effects asymmetrically distributed AuNPs. The NIR provides energy for propulsion activates nanomotor's antibacterial properties, allowing it penetrate biofilms kill bacteria. Additionally, ability scavenge reactive oxygen species (ROS) can modulate immune response create regenerative environment, promoting healing Overall, this multifunctional offers promising treating periodontitis simultaneously addressing biofilm management modulation autonomous movement.
Language: Английский
Citations
7
mSystems, Journal Year: 2024, Volume and Issue: 9(7)
Published: June 28, 2024
The gastric microbial community plays a fundamental role in cancer (GC), and the two main anatomical subtypes of GC, non-cardia cardia are associated with different risk factors (
Language: Английский
Citations
6
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 14
Published: Jan. 5, 2024
Background: Chronic kidney disease (CKD) is now globally recognized as a critical public health concern. Vascular calcification (VC) represents significant risk factor for cardiovascular events in individuals with CKD. It the accessible and precise diagnostic biomarkers monitoring progression of CKD concurrent VC are urgently needed. Methods: The adenine diet-induced rat model was utilized to investigate chronic injury, thoracic aorta, dysregulation biochemical indices. Enzyme-linked immune sandwich assays were employed analyze changes calcification-related proteins. 16S rRNA sequencing performed delineate microbiota characteristics gut blood CKD-afflicted rats. Additionally, transcriptome tissue conducted explore relationship between CKD-associated features alterations function. Results: inhibited body weight gain, led pronounced aorta. both these affected rats exhibited significantly lower alpha diversity distinctive beta than those their healthy counterparts. resulted several indices (including elevated levels creatinine, low-density lipoprotein-cholesterol, sodium, phosphorous, total cholesterol, urea decreased albumin, calcium, lactate dehydrogenase, bilirubin). Moreover, it upregulated factors (bone sialoprotein [BSP], Klotho, fibroblast growth [FGF]-23, sclerostin [SOST]) lipopolysaccharide (LPS). Notably, increased Acinetobacter positively associated calcifications addition positive correlation microbiota. enrichment increases (BSP, FGF-23, SOST), LPS, phosphorous. Furthermore, revealed that correlated majority genes negatively downregulated involved mineral absorption pathway. Conclusion: Our findings, first time, underscore dysbiosis symbiotic microbiota, blood, Particularly, emerges potential its accompanying VC.
Language: Английский
Citations
5
Infection and Immunity, Journal Year: 2024, Volume and Issue: 92(9)
Published: March 4, 2024
ABSTRACT Streptococcus agalactiae (Group B , GBS) is a Gram-positive bacterial species that causes disease in humans across the lifespan. While antibiotics are used to mitigate GBS infections, it evident disrupt human microbiomes (which can predispose people other diseases later life), and antibiotic resistance on rise. Taken together, these unintended negative impacts of highlight need for precision approaches minimizing disease. One possible approach involves selectively depleting its commensal niches before cause at body sites or be transmitted at-risk individuals. understudied niche adult gastrointestinal (GI) tract, which may colonization individuals risk However, better understanding host-, microbiome-, GBS-determined variables dictate GI carriage needed precise decolonization developed. In this review, we synthesize current knowledge diverse occupied by as pathogen commensal. We summarize key molecular factors utilizes colonize different host-associated inform future efforts study tract. also discuss commensals pathogenic emphasize broader utility de-colonization mitigating infections pathogens. Finally, how treatments could improved with more holistic enabled continued GI-focused study.
Language: Английский
Citations
5