The matrix in cancer

Nature reviews. Cancer, Journal Year: 2021, Volume and Issue: 21(4), P. 217 - 238

Published: Feb. 15, 2021

Language: Английский

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The principles of directed cell migration

Nature Reviews Molecular Cell Biology, Journal Year: 2021, Volume and Issue: 22(8), P. 529 - 547

Published: May 14, 2021

Language: Английский

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Cytoskeletal Crosstalk in Cell Migration

Trends in Cell Biology, Journal Year: 2020, Volume and Issue: 30(9), P. 720 - 735

Published: July 13, 2020

Language: Английский

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Cell–extracellular matrix mechanotransduction in 3D

Nature Reviews Molecular Cell Biology, Journal Year: 2023, Volume and Issue: 24(7), P. 495 - 516

Published: Feb. 27, 2023

Language: Английский

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The extracellular matrix in development

Development, Journal Year: 2020, Volume and Issue: 147(10)

Published: May 15, 2020

ABSTRACT As the crucial non-cellular component of tissues, extracellular matrix (ECM) provides both physical support and signaling regulation to cells. Some ECM molecules provide a fibrillar environment around cells, while others sheet-like basement membrane scaffold beneath epithelial In this Review, we focus on recent studies investigating mechanical, biophysical cues provided developing tissues by different types in variety organisms. addition, discuss how helps regulate tissue morphology during embryonic development governing key elements cell shape, adhesion, migration differentiation.

Language: Английский

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Crosstalk between mechanotransduction and metabolism

Nature Reviews Molecular Cell Biology, Journal Year: 2020, Volume and Issue: 22(1), P. 22 - 38

Published: Nov. 13, 2020

Language: Английский

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Vimentin Is at the Heart of Epithelial Mesenchymal Transition (EMT) Mediated Metastasis

Cancers, Journal Year: 2021, Volume and Issue: 13(19), P. 4985 - 4985

Published: Oct. 5, 2021

Epithelial-mesenchymal transition (EMT) is a reversible plethora of molecular events where epithelial cells gain the phenotype mesenchymal to invade surrounding tissues. EMT physiological event during embryogenesis (type I) but also happens fibrosis II) and cancer metastasis III). It multifaceted phenomenon governed by activation genes associated with cell migration, extracellular matrix degradation, DNA repair, angiogenesis. The employ acquire ability migrate, resist therapeutic agents escape immunity. One key biomarkers vimentin, type III intermediate filament that normally expressed in upregulated metastasis. This review highlights pivotal role vimentin explains its as downstream well an upstream regulator this highly complex process. areas require further research exploring EMT. As cytoskeletal protein, filaments support mechanical integrity migratory machinery, generation directional force, focal adhesion modulation attachment. viscoelastic scaffold, it gives stress-bearing flexible organelles. However, modulates for inducers such Snail, Slug, Twist ZEB1/2, epigenetic factors. In addition, suppresses cellular differentiation upregulates their pluripotent potential inducing self-renewability, thus increasing stemness stem cells, facilitating tumour spread making them more resistant treatments. Several missense frameshift mutations reported human cancers may contribute towards metastatic spread. Therefore, we propose should be target using technologies will curb growth reduced mortality morbidity.

Language: Английский

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Mechanics and functional consequences of nuclear deformations

Nature Reviews Molecular Cell Biology, Journal Year: 2022, Volume and Issue: 23(9), P. 583 - 602

Published: May 5, 2022

Language: Английский

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The extracellular matrix and the immune system: A mutually dependent relationship

Science, Journal Year: 2023, Volume and Issue: 379(6633)

Published: Feb. 16, 2023

For decades, immunologists have studied the role of circulating immune cells in host protection, with a more recent appreciation resident within tissue microenvironment and intercommunication between nonhematopoietic cells. However, extracellular matrix (ECM), which comprises at least third structures, remains relatively underexplored immunology. Similarly, biologists often overlook regulation complex structural matrices by system. We are only beginning to understand scale ECM structures determine cell localization function. Additionally, we need better how dictate complexity. This review aims highlight potential for biological discovery interface immunology biology.

Language: Английский

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Enhanced substrate stress relaxation promotes filopodia-mediated cell migration

Nature Materials, Journal Year: 2021, Volume and Issue: 20(9), P. 1290 - 1299

Published: April 19, 2021

Language: Английский

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